Dr Mirko Pegoraro (PhD) cv
home page
research
cv
University of Leicester Home Page
contact

Dr Mirko Pegoraro (PhD) Curriculum Vitae

 

CV printable version

Crazy study

Research interests

"Nothing in biology makes sense except in the light of evolution" Dobzhansky T. Dobzhansky's remark is at the base of my scientific interests. I seek to understand evolution through natural selection at multiple levels, from its molecular mechanisms to a possible epigenetic component. A deep understanding of the relationship between genes, their function, and their evolution, shall give us a better opportunity to explain the delicate interactions between individuals, different species and the environment.

Education

2002-2004: PhD in Genetics and Molecular Biology of Development (University of Padova, Italy) Supervision: Prof. Rodolfo Costa. Thesis: "Genetics and functional analysis of a length polymorphism in the Drosophila melanogaster timeless gene".

1995-2001: Laurea in Biological Sciences (5 years degree). University of Padova, Italy. 103/110.

Employment

2007 to date: Research Associate, Department of Genetics, University of Leicester, UK (with Dr Eran Tauber).

2005-2007: Post-doctoral Fellow, Department of Biology, University of Padova, Italy (with Prof. Rodolfo Costa).

2004-2005: One year project fellowship (with Prof. Rodolfo Costa).

2002-2004: PhD studentship at the Department of Biology, University of Padova, Italy.

2002: Adviser in paternity determination lawsuits.

2001-2002: Tutor (new student support and orientation) at the University of Padova.

Additional training

June 2004: Spring School of Chronobiology (University of Groningen, Holland).

2003-2004: Erasmus exchange programme, Department of Genetics, University of Leicester, UK (with Dr Ezio Rosato).

Teaching experience

2007 to date: Teaching qPCR practical to MSc Molecular Genetics students. Support and laboratory training of technicians, undergraduate, Masters and PhD students, University of Leicester, UK.

2007-2014: Teaching genetics tutorials to first-year Biological Sciences students, University of Leicester, UK. Demonstrating Staden Practical to PhD students.

2013: Demonstrating Molecules, Genes and Disease Section to first-year Medical Genetics students.

2002-2007: Support and laboratory training of undergraduate and PhD students, University of Padova, Italy.

Outreach

25 November 2015: Career Talk for Leicester High school for Girls (Leicester, UK). Talk title: "Answering Science's Call".

10 August 2015: Career Talk for the EEEP Jose' Ribeiro Damasceno (Trairi –CE -Brazil). Talk title: "A journey to be a geneticist". Talk given in Portuguese.

14 March 2015: Senior section Judge for the Regional School of Biology Poster competition.

1 November 2014: Speaker for the Beauchamp College (Leicester) open day. Talk title: "A journey to be a geneticist".

2013 to date: Workshop Leader for the educational programme LiveGene! in Eran Tauber’s laboratory.

22 March 2014: Senior section Judge for the Regional School of Biology Poster competition.

2 November 2013: Speaker for the Beauchamp College (Leicester) open day. Talk title: "A journey to be a geneticist".

22 May 2013: Demonstrator for Richard the III outreach (organized by GENIE).

16 March 2013: Senior section Judge for the Society of Biology Regional Schools Poster Competition.

2-8 July 2012: Exhibitor at the Royal Society's Summer Science Exhibition 2012, Breathless Genes, University of Leicester, UK.

10 March 2012: Junior section Judge for the Society of Biology Regional Schools Poster Competition.

2007 to date: Teaching to year 9 and college students and to adults during GENIE and HERO open days, University of Leicester, UK.

Invited talks

10 Aprile 2015: Nucleotide variation in Drosophila cryptochrome linked to circadian clock function: an association analysis. Clock Club, University of Surrey, UK.

8 January 2015: Nucleotide variation in Drosophila cryptochrome linked to circadian clock function: an association analysis. PopGroup48, 6-9 January, Sheffield UK.

8 December 2014: Genetic dissection of insects photoperiodic response. Departmental talk, University of Wu¨rzburg, Department of Neurobiology and Genetics, Germany.

28 February 2014: Role for the circadian clock genes in seasonal timing in Drosophila. Departmental talk, University of Minnesota, Department of Genetics, Cell Biology and Development, USA.

25 January 2013: Latitudinal clines in Drosophila clock genes: the good, the bad, and the ugly. Genome Science Theme/ Athena SWAN research day, UK.

30 April 2012: Natural variation in Drosophila Cryptochrome. Clock Club. University of Leicester, UK.

22 August 2011: Seasonal timing: is the circadian clock required? XII Congress of the European biological rhythms society, 20-26 August 2011,Oxford UK.

15 September 2010: Diapausa in popolazioni europee di Drosophila melanogaster. Workshop su orologi circadiani e diapausa negli insetti. University of Padova.

17 March 2008: Natural Variation in Drosophila cryptochrome. Clock Club. University of Leicester.

Additional roles

4 October 2013: Main Promoter and Organizer of the first college of Medicine, Biological Sciences and Psychology's Research Staff Day.

2013-2014: Member of the college of Medicine, Biological Sciences and Psychology's Early Career Researcher Development group.

2013-2014: Member of the University of Leicester's Concordat for the Career Development of Researcher steering group.

2012-2014: Member of the Department of Genetics Athena SWAN group (charter for women in science).

2012-2015: Fire warden for the University of Leicester Genetics Department.

2011-2014: Member of the University of Leicester's Genome Science Research Theme steering group.

2010-2013: Department of Genetics post-doc representative, attending staff meetings.

Publications

Pegoraro M, Bafna A, Davies N, Shuker D, and Tauber E "DNA methylation changes induced by long and short photoperiods in Nasonia". Genome Research, 2015, DOI: 10.1101/gr.196204.115.

Pegoraro M, Picot E, Hansen CN, Kyriacou CP, Rosato E and Tauber E "Gene expression associated with Early and Late chronotypes in Drosophila melanogaster". Frontiers in Neurology, section Sleep and Chronobiology, 2015, DOI: 10.3389/fneur.2015.00100.

Green EW, O'Callaghan EK, Pegoraro M, Armstrong JD, Costa R, Kyriacou CP "Genetic analysis of Drosophila circadian behavior in seminatural conditions". Methods in Enzymology, 2015, 551:121-133.

Pegoraro M, Gesto J, Kyriacou CP and Tauber E "Role for circadian clock genes in seasonal timing: Testing the Bunning hypothesis". PLOS Genetics, 2014, DOI: 10.1371/journal.pgen.1004603.

Pegoraro M, Noreen S, Bhutani S, Tsolou A, Schmid R, Kyriacou CP, and Tauber E "Molecular Evolution of a pervasive natural amino-acid substitution in Drosophila cryptocrhome". PLOS ONE, 2014, 9: doi: 10.1371/journal.pone.0086483.

Vanin S, Bhutani S, Montelli S, Menegazzi P, Green EW, Pegoraro M, Sandrelli F, Costa R, Kyriacou CP "Unexpected features of Drosophila circadian behavioural rhythms under natural conditions". Nature, 2012, 484:371-5.

Pegoraro M, Tauber E "Animals clocks: a multitude of molecular mechanisms for circadian timekeeping". Wires RNA, 2011, 2:312–320.

Pegoraro M, Tauber E "The role of microRNAs (miRNA) in circadian rhythmicity". Journal of Genetics, 2008, 87:505-11.

Sandrelli F, Tauber E, Pegoraro M, Mazzotta G, Cisotto P, Landskron J, Stanewsky R, Piccin A, Rosato E, Zordan M, Costa R, Kyriacou CP "A molecular basis for natural selection at the timeless locus in Drosophila melanogaster". Science, 2007, 316:1898-900.

Tauber E, Zordan M, Sandrelli F, Pegoraro M, Osterwalder N, Breda C, Daga A, Selmin A, Monger K, Benna C, Rosato E, Kyriacou CP, Costa R "Natural selection favors a newly derived timeless allele in Drosophila melanogaster". Science 2007, 316:1895-8.

Sandrelli F, Cappellozza S, Benna C, Saviane A, Mastella A, Mazzotta DM, Moreau S, Pegoraro M, Piccin A, Zordan MA, Cappellozza L, Kyriacou CP, Costa R "Phenotypic effects induced by knock-down of the period clock gene in Bombyx mori". Genetics Research, 2007, 89:73-84.

Zordan MA, Cisotto P, Benna C, Agostino A, Rizzo G, Piccin A, Pegoraro M, Sandrelli F, Perini G, Tognon G, De Caro R, Peron S, te Kronniè T, Megighian A, Reggiani C, Zeviani M, Costa R "Post Transcriptional silencing and functional characterization of the Drosophila melanogaster homolog of human surf1". Genetics, 2006, 172:229-41

Manuscripts currently under review

Pegoraro M, Zonato V, Tyler L, Fedele G, Patel N, Vanin S, Costa R, Kyriacou CP, and Tauber E "Diapause is an ancient adaptation in Drosophila melanogaster and Drosophila simulans populations". To be submitted (ms in preparation).

Abstracts

Pegoraro M, Gesto JS, Kyriacou CP, Tauber E "Does the Drosophila seasonal timer require a circadian clock?" SRBR 14-18 June, Big Sky, Montana.

Pegoraro M, Bafna A, Tauber E "Role of DNA methylation in photoperiodic timing". SRBR 19-23 May 2012, Sandestin, Florida.

Pegoraro M, Noreen S, Bhutani S, Schmid R, Kyriacou CP, Tauber E "Natural variation in cryptochrome in wild population of Drosophila". SRBR 19-23 May 2012, Sandestin, Florida.

Pegoraro M, Tauber E "Seasonal timing: is the circadian clock required?" EBRS 20-26 August 2011, Oxford, UK.

Pegoraro M, Tauber E "Is the circadian clock required for seasonal timing". GRC Chronobiology 12-17 June 2011, Lucca, Italy.

Pegoraro M, Kyriacou CP, Tauber E "Molecular correlates of photoperiodic diapause in Drosophila melanogaster". SRBR 22-26 May 2010, Sandestin, Florida.

Pegoraro M, Bhutany S, Schmid R, Tauber E "Naturally occurring variation in cryptochrome in European populations of Drosophila". SRBR 18-21 May 2008, Sandestin, Florida.

Costa R, Piccin A, Zordan MA, Cisotto P, Benna C, Sandrelli F, Pegoraro M, Lanfranchi G, Valle G, De Bernard M, te Kronnie T, Agostino A, Zeviani M, Megighian A, Tijskens P, Peron S, Reggiani C "Functional Knock-out and characterization of Drosophila homologs to human muscle genes: Spin90, Keap1, Surf1, Zasp". XIII Telethon convention 6-8 March 2005, Salsomaggiore Terme., Italy

Zordan MA, PiccinA, Cisotto P, Benna C, Pegoraro M, te Kronnie T, Agostino A, Zeviani M, Peron S, Reggiani C, Costa R "Functional characterisation of dsRNAi knockdown of Drosophila melanogaster homolog of human Surf1". 10th European Symposium on Drosophila Neurobiology 4-8 September 2004, Neuchatel, Switzerland.

Costa R, Piccin A, Zordan MA, Cisotto P, Benna C, Sandrelli F, Pegoraro M, Lanfranchi G, Valle G, De Bernard M, te Kronnie T, Agostino A, Zeviani M, Megighian A, Tijskens P, Peron S, Reggiani C "Functional Knock-out and characterisation of Drosophila homologs to human muscle genes: Spin90, Keap1, Surf1, Zasp". XII Telethon convention 23-25 November 2003, Riva del Garda, Italy.

Pegoraro M, Sandrelli F, Zordan MA, Mazzotta GM, Cisotto P, Osterwalder N, Daga A, Rosato E, Kyriacou CP, Costa R "Analisi genetica e funzionale di un polimorfismo di lunghezza del gene orologio timeless in Drosophila melanogaster". V convegno FISV 10-13 October 2003, Rimini, Italy.

Zordan MA, Sandrelli F, Pegoraro M, Cisotto P, Osterwalder N, Piccin A, Daga A, Mazzotta GM, Rosato E, Tauber E, Kyriacou CP, Costa R "Genetic and functional analysis of a length polymorfism in the Drosophila melanogaster circadian clock gene timeless". Population Genetics Group 2003, 5-8 January 2003, University of Leicester (UK).

Costa R, Piccin A, Zordan MA, Cisotto P, Sandrelli F, Pegoraro M, Lanfranchi G, Valle G, Toppo S, De Bernard M, te Kronniè T, Agostino A, Zeviani M, Megighian A, Tijskens P, Peron S, Reggiani C "Functional Knock-out and characterisation of Drosophila Homologs to human muscle genes: sarc, spin90, surf". Scentific Convention Telethon, 24-26 November 2002, Riva del Garda, Italy.

 

CV printable version

home page research cv University of Leicester contact

© 2009 Dr Mirko Pegoraro
mp248@le.ac.uk
Twitter: @MirkoPegoraro75 Facebook: Mirko Pegoraro