Myeloma is a malignancy of bone marrow, which leads to the production of abnormal plasma cells in the marrow. It can be diagnosed if two or more of the following are present: abnormal plasma cells on marrow biopsy, bony hole-punch lesions on X-ray, and the presence of IgG light chains in the urine and blood serum (Bence-Jones protein). Symptoms include bone pain, blurred vision, raised serum calcium, anaemia, and renal failure due to deposition of amyloid protein in the kidneys.

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