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Synchronization of oscillations by coupling PP oscillators

New work published in February 2010 shows that weak coupling between cellular oscillators can lead to rapid synchronization. With such a strong effect, there is often no need for cellular processes to be connected to any centralized or controlling clock.

Systems Biology, Networks and Robust Control

The research group in this area at the University of Leicester includes Pat Heslop-Harrison. There are many collaborators, including those who have now moved from Leicester to Deputy Vice Chancellorships, Professorships and Lectureships elsewhere between 2008 and 2010. Links to their current positions are given with the names.

Professor Pat Heslop-Harrison

Collaborators:
Professor Declan Bates

Professor Ian Postlethwaite

Dr. Jongrae Kim

Dr. Jung-Su Kim

Dr. Najl Valeyev

 

  Professor Pat Heslop-Harrison

Email: phh4_at_leicester.ac.uk
Tel: +44 (0) 116 252 3381
Fax: +44 (0) 116 252 2791
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Research Interests

Systems biology and interactions between genes.

Robustness of control and regulation in biology.

Networks and genetic interactions.

Quantitative traits, their control and identification in genetics.
Dr. Declan G. Bates

Research Interests

Robustness and feedback control in biological systems

Oscillatory cAMP signalling in the development of Dictyostelium discoideum

Feedback control mechanisms in the Tryptophan operon in E.coli

Simulation models for analysing inhibition profiles, cytotoxicity etc of novel anti-tumour drugs

Reverse engineering biological networks using system identification

Integration of wet-lab experiments with modelling and computational analysis of biological control systems

Respiratory physiology
  Professor Ian Postlethwaite

 

                                             

Research Interests

Theoretical contributions to the field of robust multivariable control

The development of advanced control system design and analysis methods and their application to complex systems

Feedback control in biological systems
  Dr. Jongrae Kim

Email: jkim@aero.gla.ac.uk
Tel: +44-(0)141-330-8646
Fax: +44-(0)141-330-5560
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Research Interests

Robustness and sensitivity analysis of complex biomolecular networks

The inference of dynamic network interactions using system identification and optimisation tools

Evolutionary dynamics: the origins of complexity and robustness in biomolecular networks

Analysis of complex networks
  Dr. Jung-Su Kim

Email: jungsu.kim@gmail.com                   
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Research Interests

Robustness and sensitivity analysis of biochemical networks

Synchronization of coupled oscillators both in engineering and nature

Model predictive control  (MPC)

Adaptive control (hybrid control approach)

Nonlinear output feedback control

Dr. Najl Valeyev

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Research Interests

The development of in silico molecular models of phamaceutically important signal transduction pathways that regulate intracellular processes involved in human diseases.

The development of models that are strictly formulated according to experimental data and biophysical principles, that reproduce experimental data, and that make new predictions that cannot be seen from experiments only.

The use of mathematical models as tools for preclinical and clinical drug development pipeline.
 

 

 Will Bryant

 

 Additional External Collaborators

Prof. Kwang-Hyun Cho,  Laboratory for Systems Biology and Bio-Inspired Engineering, KAIST, Korea.
 
Prof. Nikolai Kotov, Biophysics & Bionics Lab, Department of Physics, Kazan State University, Kazan, Russian Federation.
 
 
 
 

 

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