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Completed
Studies: |
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- Investigation
of the potential for indole-3-carbinol to prevent aflatoxin B1-induced
liver cancer in rats.
- I3C was found to protect against tumour formation whether
give two weeks before or six weeks after treatment with AFB1
commenced.
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Investigation
of the ability of isoflavanoids and lignans in soya to interfere
with the transduction of cellular signals which might promote breast
cancer. In this work the effects of genistein, equol, enterodiol and
enterolactone on the growth of human breast cancer cells and on
mitogen- or tumour promotor-induced early response gene expression
were assessed.
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- In
a clinical pilot study of a turmeric extract curcuminoids were found
to be safe, but curcumin was not detected in plasma. A curcumin conjugate was identified in faeces. Levels of inducible COX-2 or malonaldehyde DNA adducts in
blood of recipients were not affected by curcumin.
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- In
a search for putative cancer chemopreventive constituents of brown
rice bran, several potentially beneficial molecules were
characterised on the basis of their ability to interfere with
proliferation of human-derived breast and colon cancer cells. Most interesting among these agents is the flavone tricin.
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Ongoing Studies:
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- Development
of new mass spectrometric techniques to detect chemopreventive
agents, including curcumin, I3C, tricin and resveratrol, and their
metabolites.
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Exploration
of mechanisms of cancer chemoprevention by curcumin, a constituent
of turmeric, which prevents colon cancer in rodents, particularly
with respect to inhibition of the activity of the transcription
factor NF- which upregulates many genes involved in the proinflammatory
response and in cell survival. Curcumin behaves in some ways like the anti-inflammatory drug aspirin. |
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Raw turmeric
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Unravelling
of the relationship between efficacy and pharmacokinetics of curcumin in
Min mice (a model of adenomatous polyposis coli, a severe preneoplastic
condition that, in humans, predisposes individuals to colon cancer). Elucidation of the metabolism of curcumin in humans and rodents,
in vitro, in tissue preparations, and in vivo.
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Curcumin powder
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