Dr Paul Jarvis Import of nucleus-encoded proteins into chloroplasts; and strategies used by plant hosts in controlling the activity of DNA-type transposable elements.
Dr Trude Schwarzacher Function of meiotic and recombination specific genes, gene expression and promoter studies.
Department of Cancer Studies and Molecular Medicine (Leicester Royal Infirmary)
Professor Rosemary Walker Research focuses on understanding biological aspects of human breast and breast cancer and relating this to the clinical situation.
Dr Marcus Cooke The role of genotoxicology in the pathogenesis of disease is the central theme in my research programme, focussed primarily upon free radical mechanisms of cellular damage, particular oxidative DNA damage and repair.
Dr G Don Jones Radiotherapy and chemotherapy, used either singly or in combination, are two of the principal modalities of cancer treatment. For radiation and many chemotherapeutic drugs, genomic DNA is the primary cellular target for the damaging effects of these agents; indeed it is the DNA damage induced which is thought to be responsible for the killing of the cancer cells.
Dr Howard Pringle The main emphasis of my current research is to investigate the molecular and cellular mechanisms that influence early stages of cancer and effect the progression of this disease. To achieve this I interact with two research groups, one studying skin cancer and the other investigating breast cancer.
Dr Jacqueline Shaw Collaboration with Prof. R.A. Walker and Dr. J.L. Jones (Pathology). Application of molecular approaches to microdissected tumour tissue with analysis of mutator and suppressor pathways. Analysis of oestrogen receptors a and b and variants in breast cancers and surrounds. Analysis of tumour specific alterations in plasma DNA from breast cancer patients. Analysis of the invasion-promoting function of the myofibroblast: role of a5b1 integrin.
The Department of Cardiovascular Science
Dr Nelson Chong Coronary Heart Disease, Circadian Timing and Cardiovascular Function.
Dr Karl E. Herbert Research interests are, molecular and cellular mechanisms of cardiovascular ageing and oxidative DNA damage and repair in humans, mitochondria and cellular oxidative stress.
Professor Nilesh Samani Molecular genetic basis of complex cardiovascular traits, particularly hypertension and coronary heart disease.
Department of Cell Physiology & Pharmacology
Dr Steve Ennion Purinergic signalling in the cardiovascular system.
Department of Genetics
Professor Peter Williams(Head of Department) Molecular and cell biological analysis of host pathogen interactions, especially with regard to the human diarrhoeal organisms Escherichia coli, Campylobacter jejuni and Salmonella spp.
Professor Sir Alec J. Jeffreys FRS Direct analysis of the dynamics of heritable mutation in humans, and of the molecular basis and consequences of human meiotic recombination.
Professor Rhona H. Borts The roles of mismatch repair proteins in meiotic recombination, heteroduplex processing and chromosome segregation and the control of crossing over in general.
Professor Anthony J. Brookes Exploring DNA sequence variation in humans by technology development, bioinformatics, and genotyping, to understand common disease aetiology, drug responses, genome structure/function, and population genetics.
Professor Annette Cashmore Genetics of fungal pathogenicity - iron uptake and metabolism in the human pathogen Candida albicans.
Professor Yuri Dubrova The genetic risks of ionizing radiation and chemical mutagens: germline mutation induction and radiation-induced genomic instability in irradiated human families and laboratory mice.
Professor Mark Jobling Y chromosomal, autosomal and X-chromosomal haplotypes and the histories of human populations. Mutation processes, including ectopic recombination and gene conversion.
Professor Julian Ketley Gene regulation and host pathogen interactions by Campylobacter jejuni. Research areas include the characterisation of chemotaxis signal transduction pathways, lipooligosaccharidebiosynthesis and iron regulation.
Professor Charalambos P. Kyriacou The molecular basis of circadian, tidal, and seasonal behavioural rhythms in insects, annelids and mammals; also the molecular basis of sexual/aggressive behaviour in Drosophila.
Dr Peter Meacock Analysis of gene function, regulation and evolution in yeast; the genetics of B-vitamin metabolism
Dr Richard Badge The role of L1 retrotransposons (mobile sequences that constitute 17% of human DNA) in genetic diversity, genetic disease, and genome evolution of humans and primates.
Dr Julian Barwell Understanding how treatment may itself alter the cell's ability to recognise and repair further DNA damage in different groups of patients, including those who carry mutations that predispose to breast cancer.
Dr Christopher D. Bayliss Mechanistic basis for generation of mutations in tandem DNA repeat tracts of bacterial pathogens and their contributions to virulence, host adaptation and population structure.
Dr Raymond Dalgleish The identification and analysis of genes involved in the bone mineral density and osteoporosis in man; research strategies iclude the use of other model organisms.
Dr Flaviano Giorgini Molecular analysis of genetic modifiers of toxicity using yeast and mammalian models of Huntingdon's disease; genetic analysis of toxicity in yest models of neurodegenerative disorders.
Dr Colin R.A. Hewitt Real time, single cell analysis of iron metabolism and regulation by Salmonella in vitro infection.
Dr Edward J. Hollox The evolution and genetic variation of human antimicrobal genes, and the relationship of this variation with susceptibility to infectious and inflammatory disease.
Dr Celia May Using the major pseudoautosomal region and other targets within the human genome to understand patterns of DNA diversity.
Dr Peter A. Meacock Yeast molecular genetics; analysis of gene function, regulation and evolution in Saccharomyces cerevisiae and related species; biosynthesis and metabolism of the B-vitamins thiamin and pyridoxine.
Dr Julie Morrissey Molecular analysis of the pathogenesis of Staphylococcus aureus: Areas of study include the mechanisms and regulation of the adaptive stress response and biofilm formation.
Dr Ezio Rosato Molecular neurobiology of complex behaviours in Drosophila, especially circadian rhythms. Molecular investigation of diel vertical migration in Arctic and Antarctic Krill.
Dr Nicola J. Royle The investigation of telomere molecular dynamics in normal and immortal cells, including cells that use the ALT (Alternative Lengthening of Telomeres) pathway.
Dr Raffael Schaffrath Yeast as a eukaryotic model to analyse a tRNA modification pathway that controls cell proliferation and cell death by a tRNAse killer toxin.
Dr Nuala Sheehan Reader in Statistical Genetics. Research interests are
applied statistics motivated by complex problems in genetics.
Dr Chris Talbot The identification of genetic causes of brain diseases like Alzheimer's disease and the development of new therapies. A developing interest is in genomic structural variation.
Dr Fred Tata Scaffold proteins provide specificity to kinase-based signal transduction, and mediate attachment of signalling complexes to cellular motor proteins; analysis of cellullar phenotypes; targeted gene knockdown by RNAi.
Dr Eran Tauber Genes, brain and behaviour; identifying molecular mechanisms of behaviour using Drosophila as a model system; research combines molecular genetics, bioinformatics and population biology.
Dr Martin Tobin (Joint with Health Sciences) MRC Clinician Scientist Fellow.
Research into Investigation of the genetic determinants of common complex diseases and traits.
Department of Health Sciences : Epidemiology & Public Health
Professor Paul Burton Statistical methods for the analysis of genetic and environmental determinants of common complex diseases.
Professor John Thompson My research involves developing and applying new statistical methods to problems in genetics and epidemiology.
Infection Immunity & Inflammation
Professor Wilhelm Schwaeble Professor Wilhelm Schwaeble started his scientific career in the Institute of Immunology in Munich, Germany, where he worked on the molecular characterisation of complement factor H, a regulatory component of the complement system. This project was jointly supported by Professor Elisabeth Weiss (Munich) and Professors Manfred Dierich and Thomas Schulz (Innsbruck).
Faculty of Law
Professor Jean McHale Health care law and issues of ownership of human material and health care privacy.
Institute of Lung Health (Leicester Royal Infirmary)
Dr Andy Wardlaw Mechanisms of eosinophil trafficking and activation in asthma, T-cell homing to the lung in health and inflammatory lung disease.
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