Mutation and Recombination Research Program

Welcome to the web pages of Prof. Alec Jeffreys' research group, based in the Department of Genetics at the University of Leicester, UK. The information within these pages supplements the following recent, and forthcoming, publications from the Jeffreys' laboratory:

High-resolution analysis of haplotype diversity and meiotic crossover in the human TAP2 recombination hotspot.
Jeffreys, A.J., Richie, A. and Neumann, R.
Hum. Mol. Genet., 9, 724-733 (2000).

To access the TAP2 recombination hotspot pages, click here.

Intensely punctate meiotic recombination in the Class II region of the Major Histocompatibility Complex.
Jeffreys, A.J., Kauppi, L., and Neumann, R.
Nature Genetics 29, 217-222 (2001).

To access the MHC recombination pages, click here.

Crossover clustering and rapid decay of linkage disequilibrium in the Xp/Yp pseudoautosomal gene SHOX.
May, C.A., Shone, A.C. Kalaydjieva, L., Sajantila A. and Jeffreys, A.J.
Nature Genetics 31, 272-275 (2002).

To access the PAR1 recombination pages, click here

High resolution mapping of crossovers in human sperm defines a minisatellite-associated recombination hotspot.
Jeffreys, A.J., Murray J, and Neumann, R.
Hum. Cell, 2, 267-273 (1998).

Human recombination hot spots hidden in regions of strong marker association.
Jeffreys, A.J., Neumann, R., Panayi M., Myers S. and Donnelly P.
Nat. Genet., 37, 601-606 (2005).

Factors influencing recombination frequency and distribution in a human meiotic crossover hotspot.
Jeffreys, A.J., and Neumann, R.
Hum. Mol. Genet., 14, 2277-2287 (2005).

To access the MS32 recombination hotspot pages, click here.

Influence of allele lineage on the role of the insulin minisatellite in susceptibility to type 1 diabetes.
Stead, J.D.H., Buard, J., Todd, J.A. and Jeffreys, A.J.
Hum. Mol. Genet., 9, 2929-2935 (2000).

Allele diversity and germline mutation at the insulin minisatellite.
Stead, J.D.H. and Jeffreys, A.J.
Hum. Mol. Genet., 9, 713-723 (2000).

To access the insulin minisatellite pages, click here.