SNP haplotypes in the 95kb interval extending across hotspots MS32, MSTM1a and 1b, and MSTM2
These haplotypes were determined experimentally from 26 semen donors (men 1-26), with each haplotype labelled a or b. Haplotypes extending upstream of MS32 were established for only three men. Alleles in haplotype 10b are labelled red, and alternative alleles blue. Haplotypes marked in red were fully resequenced over the interval M+14.3 to M+25.6, and all new SNPs so discovered were typed across all haplotypes. The three underlined haplotypes are active at hotspot MSTM1a.
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hotspot: MS32 ---MSTM1a-- -MSTM1b- MSTM2
SNP: MMMMMMMMMMMMMMMMMMMMAAAAAABRBXABRMSHHHHBSEMBMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMM --------------------24681lascbwst1a1f2pbfc+l++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++ 55555555555555443322 0 3 51111111111111111111111111111M1111222222222222222222222222222222222222333333333333333333333333 77666555431000971179 . .1223344444455566666777778888E9999000000000111111111222223334455778899000011222222223444555578 .................... 7 4............................I................................................................ 10986554525740269896 8242634578956823679024770577D5699001234789224555699011388990456352612125819011338992356357863 a a a a a a ab a a a a a a a a |
Man 1a TGGGGAGACGGGGCC+AACACTGGGTAGTTCTACG+GGCGTGCTTAGTTGGTTGAGGCGTTGGGGCGGCTTG-GTCGCGGGACTCCGCGAGCTCAACTAA 1b CGGAGCGGTAGAGTT-GGAGTTGAGAAGTCCTGCG+GGCGTCCTTAACCAATTGGGCTGCGCGGGCGGTACC+GCTGTAGTGCCTTATAGAAATGGCTAA 2a CGAGGAGACGGGGCC+AACACTGGGTAGTCCTATG+GGCGTGCTTAGTTGGTTGAGGCGTTGGGGCGGCTTG-GTCGCGGGACTCCGCGAGCTCAACTAA 2b CCGGAAAGTAGAGTT-GGAGTTGGGAAGTCCTGCG+GGCGTCCTTAACCAATTGGGCTGCGCGGGCGGTACC+GCTGTAGTGCTCCGCGAGCTCAACTAA 3a TGGGGAGACGGGGCC+AACACTGGGTAGTTCTACG+GGCGTGCTTAGTTGGTTGAGGCGTTGGTACAGCTCG-GCCCCAATAGCTCGTAGAAATGGTCCA 3b CCGGAAAACGAAATT-GAAGCCAAATGACCTGGCG-TAAAAGTCCGACCAATTGGGCTGCGCGGGCGGTACC+GCTGTAGTGCTCCGCGAGCTCAACTCA 4a TGGGGAGACGGGGCC+AACACTGGGTAGTCCTACG+GGCGTGCTTAGTTAAGTCGCGTGCGCGTACAGCTCG-GCCCCAATAGCTCGTAGAAATGGTCCA 4b CGGAGCGGTAGAGTT-GGAGTTGGGAAGTCCTGCG+GGCGTCCTTAACCAATTGGGCTGCGCGGGCGGTACC+CCTGTAGTGCCTTATAGAAATGGTCCA 5a GGATGCCTAGCCTGCAGTGGACACAAGTTTCGATCG+CCGGAGCGGTAGAGTT-GGAGTTGGGTAGTCCTACA+GGCGTGCTTAGTTGGTTGAGGCGTTGGTACAGCTCG-GCCCCAATAGCTCGTAGAAATGGTCCA 5b GGATGCCTAGCCTGCAGTGGACACAAGTTTCGATCG+CTGGGGAGACGGGGCC+AAAGCCAAATGACCTGGCG-TAAAAGTCCGACCAATTGGGCTGCGCGGGCGGCTTG-GTCGCGGGACTCCGCGAGCTCAACTAA 6a TGGGGAGACGGGGCC+AACACTGGGTAGTTCTACG+GGCGTGCTTAGTTGGTTGAGGCGTTGGGGCGGCTTG-GTCGCGGGACTCCGCGAGCTCAACTAA 6b CGGAGCGGTAGAGTT-GGAGTTGGGAAGTCCTGCG+GGCGTCCTTAACCAATTGGGCTGCGCGGGCGGTACC+CCTGTAGTGCCTTATAGAAATGGTCCA 7a CGGAGCGGTAGAGTT-GGAGTTGAGTAGTCCTACG+GGCGTGCTTAGTTGGTTGAGGCGTTGGTACAGCTCG-GCCCCAATAGCTCGCGAGCTCAACTCA 7b CGGAGCGGTAGAGTT-GGAGTTGAGAAGTCCTGCG+GGCGTCCTTAACCAATTGGGCTGCGCGGGCGGTACC+GCTGTAGTGCTCCGCGAGCTCAACTAA 8a TGGGGAGACGGGGCC+AACGCTGGGTAGTCCTACG+GGCGTGCTTAGTTAAGTCGCGTGCGCGTACAGCTCG-GCCCCAATAGCTCGTAGAAATGGTCCA 8b CCGGAAAACGAAATT-GAAGCCAAATGACCTGGCG-TAAAAGTCCGACCAATTGGGCTGCGCGGGCGGTACC+GCTGTAGTGCTCCGCGAGCTCAACTCA 9a GGATGCCTAGCCTGCAGTGGACACAAGTTTCGATCG+CTGGGGAGACGGGGCC+AACACTGGGTAGTCCTACG+GGCGTGCTTAGTTGGTTGAGGCGTTGGGGCGGTACC+GCTGTAGTGCCTTATAGAAATGGCTCT 9b AGAAATCCGAGTCCAAACAATTGACTTTCCTAACCC+TCGAGGCGACGGGGCC+AACACTGGGTAGTCCTGCG+GGCGTCCTTAACCAATTGGGCTGCGCGGGTGACTCC+GCCCCAGTACTCCGCGAGAATGGCTCA 10a GGATGCCTAGCCTGCAGTGGACACAAGTTTCGATCG+CTGGGGAGACGGGGCC+AACACTGGGTAGTCCTACG+GGCGTGCTTAGTTGGTTGAGGCGTTGGGGCGGCTTG-GTCGCGGGACTCCGCGAGCTCAACTAA 10b ACCAATTCGAGCCCCGGTAATTGACTTGCCTAGCTG-TCCGGAAAACGAAATT-GAAGCCAAATGACCTGGCG-TAAAAGTCCGACCAATTGGGCTGCGCGGGCGGTACC+GCTGTAGTGCTCCGCGAGCTCAACTCA 11a CGAGGAGGTAGAGTC-AGAGTTGGGTAGTCCTACG+GGCGTGCTTAGTTGGTTGAGGCGTTGGTACAGCTCG-GCCCCAATAGCTCGTAGAAATGGTCCA 11b CCGGAAAACGAAATT-GAAGCCAAATGACCTGGCG-TAAAAGTCCGACCAATTGGGCTGCGCGGGCGGTACC+GCTGTAGTGCTCCGCGAGCTCAACTAA 12a TGGGGAGACGGGGCC+AACACTGGGTAGTCCTACG+GGCGTGCTTAGTTAAGTCGCGTGCGCGTACAGCTCG-GCCCCAATAGCTCGTAGAAATGGTCCA 12b CCGGAAAACGAAATT-GAAGCCAAATGACCTGGCG-TAAAAGTCCGACCAATTGGGCTGCGCGGGCGGTACC+GCTGTAGTGCTCCGCGAGCTCAACTCA 13a CGGAGCGGTAGAGTT-GGAGTTGGGTAGTCCTACG+GGCGTGCTTAGTTGGTTGAGGCGTTGGTACAGCTCG-GCCCCAATAGCTCGTAGAAATGGTCCA 13b CGGAGCGGTAGAGTT-GGAGTTGGGAAGTCCTGCG+GGCGTCCTTAACCAATTGGGCTGCGCGGGCGGTACC+GCTGTAGTGCTCCGCGAGCTCAACTCA 14a TGGGGAGACGGGGCC+AACACTGGGTAGTCCTACG+GGCGTGCTTAGTTGGTTGAGGCGTTGGGGCGGCTTG-GTCGCGGGACTCCGCGAGCTCAACTAA 14b CCGGAAAACGAAATT-GAAGCCAAATGACCTGGCG-TAAAAGTCCGACCAATTGGGCTGCGCGGGCGGTACC+GCTGTAGTGCTCCGCGAGCTCAACTCA 15a CGGAGCGACGGGGCC+AACACTGGGTAGTCCTACG+GGCGTGCTTAGTTGGTTGAGGCGTTGGGGCGGCTTG-GTCCCAATAGCTCGTAGAAATGGTCCA 15b CCGGAAAGTAGAGTT-GGAGTTGAGAAGTCCTGCG+GGCGTCCTTAACCAATTGGGCTGCGCGGGCGGTACC+GCTGTAGTGCTCCGCGAGCTCAACTAA 16a CGAGGAGACGGGGCC+AACACTGGGTAGTCCTATG+GGCGTGCTTAGTTGGTTGAGGCGTTGGGGCGGCTTG-GTCGCGGGACTCCGCGAGCTCAACTAA 16b CCGGAAAGTAGAGTT-GGAGTTGAGAAGTCCTGCG+GGCGTCCTTAACCAATTGGGCTGCGCGGGCGGTACC+GCTGTAGTGCTCCGCGAGCTCAACTAA 17a TGGGGAGACGGGGCC+AACACTGGGTAGTCCTACG+GGCGTGCTTAGTTAAGTCGCGTGCGCGTACAGCTCG-GCCCCAATAGCTCGTAGAAATGGTCCA 17b CGGAGCGGTAGAGTT-GGAGTTGAGAAGTCCTGCG+GGCGTCCTTAACCAATTGGGCTGCGCGGGCGGTACC+GCTGTAGTGCTCCGCGAGCTCAACTAA 18a CGAGGAGACGGGGCC+AACACTGGGTAGTCCTACG+GGCGTGCTTAGTCAATCGGGGTACGGAGGCGGTACC+GCTGTAGTGCCTTATAGAAATGGTCCA 18b CCGGAAAACGAAATT-GAAGCCAAATGACCTGGCG-TAAAAGTCCGACCAATTGGGCTGCGCGGGCGGCTTG-GTCGCGGGACTCCGCGAGCTCAACTAA 19a CGAGGAGACGGGGCC+AACACTGGGTAGTCCTACG+GGCGTGCTTAGTCAATTGGGCTGTTGGGGTGACTCC+GCCCCAGTACTCCGCGAGAATGGCTCA 19b CCGGAAAACGAAATT-GAAGCCAAATGACCTGGCG-TAAAAGTCCGACCAATTGGGCTGCGCGGGCGGCTTG-GTCGCGGGACTCCGCGAGCTCAACTAA 20a CGAGGAGACGGGGCC+AACACTGGGTAGTCCTATG+GGCGTGCTTAGTTGGTTGAGGCGTTGGGGCGGCTTG-GTCGCGGGACTCCGCGAGCTCAACTAA 20b CGGAGCGGTAGAGTT-GGAGTTGAGAAGTCCTGCG+GGCGTCCTTAACCAATTGGGCTGCGCGGGCGGTACC+GCTGTAGTGCCTTATAGAAATGGCTCA 21a CCGGAAAACGGGGCC+AACACTGGGTAGTCCTACG+GGCGTGCTTAGTTAAGTCGCGTGCGCGGGCGGCTTG-GTCGCGGGACTCCGTAGAAATGGTCCA 21b CGGAGCGGTAGAGTT-GGAGTTGAGAAGTCCTGCG+GGCGTCCTTAACCAATTGGGCTGCGCGGGCGGTACC+GCTGTAGTGCCTTATAGAAATGGCTAA 22a CGAGGAGACGGGGCC+AACACTGGGTAGTCCTATG+GGCGTGCTTAGTTGGTTGAGGCGTTGGGGCGGCTTG-GTCGCGGGACTCCGCGAGCTCAACTAA 22b CGAGGAGACGGGGCC+AAAGCCAAATGACCTGGCG-TAAAAGTCCGACCAATTGGGCTGCGCGGGCGGTACC+GCTGTAGTGCTCCGCGAGCTCAACTCA 23a TGGGGAGACGGGGCC+AACACTGGGTAGTCCTACG+GGCGTGCTTAGTTGGTTGAGGCGTTGGGGCGGCTTG-GTCGCGGGACTCCGTAGAAATGGTCCA 23b CGGAGCGGTAGAGTT-GGAGTTGGGAAGTCCTGCG+GGCGTCCTTAACCAATTGGGCTGCGCGGGCGGTACC+GCTGTAGTGCTCCGCGAGCTCAACTAA 24a TGGGGAGACGGGGCC+AACACTGGGTAGTTCTACG+GGCGTGCTTAGTTGGTTGAGGCGTTGGGGCGGCTTG-GTCGCGGGACTCCGCGAGCTCAACTAA 24b CCGGAAAACGAAATT-GAAGCCAAATGACCTGGCG-TAAAAGTCCGACCAATTGGGCTGCGCGGGCGGTACC+GCTGTAGTGCTCCGCGAGCTCAACTCA 25a CCGGAAAACGGGGCC+AACACTGGGTAGTCCTACG+GGCGTGCTTAGTTAAGTCGCGTGCGCGTACAGCTCG-GCCCCAATAGCTCGTAGAAATGGTCCA 25b CCGGAAAACGAAATT-GAAGCCAAATGACCTGGCG-TAAAAGTCCGACCAATTGGGCTGCGCGGGCGGTACC+GCTGTAGTGCCTTATAGAAATGGCTCT 26a CCGGAAAACGGGGCC+AACACTGGGTAGTCCTACG+GGCGTGCTTAGTTAAGTCGCGTGCGCGTACAGCTCG-GCCCCAATAGCTCGTAGAAATGGTCCA 26b CCGGAAAACGAAATT-GAAGCCAAATGACCTGGCG-TAAAAGTCCGACCAATTGGGCTGCGCGGGCGGTACC+GCTGTAGTGCCTTATAGAAATGGCTCT |
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