84 bp from 5' end of TH intron 13                 INS-1
human           GAGCAGGGCTGGACCTGTGAGCCCAGGTCACAGATGAGAAAACCGACCCCTGGYTGCAGC
chimp           ???????????????????????????????AGATGAGAAAACCGACCCCTGGTTGCAGC
gorilla         ????????????????????????????????????????????????CCTGGTTGCAGC
orang           ?????????????????????????????????????????????????CTGGTTGCAGC
                                                                ***** ******

human           AGCCCCCACACAGCAGGGACACCATCCGTGAGAAGGACCCCAGCGTCTGGGGAGGGGCAG
chimp           AGCCCCTACACAGCAGGGGCACCATCCGTGAGAAGGACCCCAGCATCTGGGGAGGGGCGG
gorilla         AGCCCCCACACGGCAGGGACACCATCCGTGAGAAGGACCCCAGCGTCTGGGGAGGGGYAG
orang           AGCCCCCACACAGCGGGGACACCATCCGTGAGAAGGACCCCAGCGTCGGGGGAGGGGCAG
                ****** **** ** *** ************************* ** *********  *

human           ACCTACAGGACTGGGGGCTGCTGGGTGGCCGGGTCAAGGCCAGTCTTGGAGGTGCTGACA
chimp           ACCTACAGGACTGGGGGCTGCTGGGTGGCCGGGTCAAGGCCAGTCTTGGAGGTGCTGACA
gorilla         ACCTACAGGACTGGGGGCTGCTGGGTGGCCGGGTCAAGGCCAGTCTTGGAGGTGCTGACA
orang           ACCTACAGTACTGGGGGCTGCTGGGTGGCCGGGTCAAAGGCAGTCTTGGAGGTGCTGGCA
                ******** **************************** * ***************** **
                                  INS-2                       INS-3
human           GAGCCTGAGCTTTGTGAGGACRTCCTGTGGAACCTGTCCCGGCCCCCTGYCCTGGGATGG
chimp           GAGCCTGAGCTTTGTGAGGATGTCCTGTGGAACCTGTCCCGGCCCCCTGCCCTGGGATGG
gorilla         GAGCCTGAGCTTTGTGAGGATGTCCTGTGGAACCTGTCCCGGCCCCCTGCCCTGGGATGG
orang           GAGCCTGAGCTTTGTGAGGAGGTCCTGTGGAACATGTCGCGGCCCCCTGCCCTGGGATGG
                ********************  *********** **** ********** **********

human           GGAGAAGTCAGGGGG-ATAGACAGAGTCAAGGTGGGGGACAGGGCGGGAGTGGGGTCCCC
chimp           GGAGAAGTCAGGGGG-ATAGACAGAGTCAAGGTCGGGGGCAGGGCGGGAGTGGGGTCCCC
gorilla         GGAGAAGTCAGGGGG-ATAGACAGAGTCAAGGTGGGGGACAGGGYGGGAGTGGGGTCCCC
orang           GGAGAAGTCAGGGGGGATAGAGAGAATCAAGGTGGGGAGCAGGGCGGGAGTGGGGTCCCC
                *************** ***** *** ******* ***  ***** ***************

human           AGGGCTGGGGGCCTTTGGTGCAGTGACCAGAGTGTCAGGAGAGGGGAGCAAAGCCCTCTA
chimp           CGGGCTGGGGGCCTTTGGCTCAGTGACCAGAGTGTCAGGAGAGGGGAGCAAAGCCCTCTA
gorilla         AGGGCTGGGGGCCTTTGGTGCAGTGACCAGAGTGTCAGGAGAGGGGAGCAAAGCCCTCTA
orang           AGGGCTGGGGGCCTTTGGTGCAATGACCAGAGTGTCAGGAGAGGGGAGCAAAGCCCACTA
                 *****************  ** ********************************* ***

human           GCCTCATCCTCATAAAAGGTCTCATCATTTTCCCTCCAGCCTCTTAT---GCACTGGGGA
chimp           GCCTCATCCCCATAAAAGGTCTCATCATTTTCCCTCCAGCCTCTTGT---GCACTGGGGA
gorilla         GCCTCATCCTCATAAAAGGTCTCATCATTTCCCCTGCAGCCTCTTGT---GCGCTGGGGA
orang           GCCTCATCCTCATAAAAGGTCTCATCATTTTCCCTCCAGCCTCTTGTTGTGCACTGGGGA
                ********* ******************** **** ********* *   ** *******

human           AACTGAGGCCAGGGGCTATGTGTCCAGCGGACAGGGGTGCTGAATTCCACCCACAGGCTT
chimp           AACTGAGGCCAGGGGCTATGTGTCCAGCGGACCGGGGTGCTGAATTCCACCCACAGGCTT
gorilla         AACTGAGGCCAGGGGCTATGTGTCCAGCGGACAGGGGTACTGAATTCTACCCACAGGCTT
orang           AACTGAGGCCAGGGGCTGTGTGCCCAGTGGACAGGGGTGCTGAATTCCACCCACAGGCTT
                ***************** **** **** **** ***** ******** ************

human           AGGGATATGGTCAAGGAAAGCTTCCTGGAGGAGGCCCAGTGGAGGTTCAGGGAGGGATGG
chimp           AGGGATATGGTCAAGGAAAGCTTCCTGGAGGAGGCCCAGTGGAGGTGCAGGGAGGGATGG
gorilla         AGGGATATGGTCAAGGAAAGCTTCCTGGAGGAGGCCCAGTGGAGGTGCAGGGAGGGATGG
orang           AGGGATATGGTCAAGGAAAGCTTCCTGGAGGAGGCCCAGTGGAGGTGCAGGGAGGGATGG
                ********************************************** *************

human           GGTGCCCGGCAG--TCTCTAGTGGAAAAGGCGCCTAGCCTATCTCCCCCATGAACCCCCT
chimp           GGTGCCCGGCAG--TCTCTAGTGGAAAAGGCGCCTAGCCTATCTCCCCCATGAACCCCCT
gorilla         GGTGCCCGGCAG--TCTCTAGTGGAAGAGGCGCCTAGCCTATCTCCCCCATGAACCCCCT
orang           GGTGCCTGGCAGAGTCTCTAGTGGAAAAGGCGCCTAGCTTATCTCCCCCATCAACCCCCT
                ****** *****  ************ *********** ************ ********

human           CACCCAGCCCTGGAAGAGGCCTCAGTGTCCCGCCTGTGACCAGTTGGCTCAGAAAAGCCC
chimp           CACCCAGCCCTGGAAGAGGCCTCAGTGTCTCGCCTGTGACCAGGTGGCTCAGAAAAGCCC
gorilla         CACCCAGCCCTGGAAGAGGCCTCAGTGTCCCGCCTGTGACCAGGTGGCTCAGAAAAGCCC
orang           CACCCAGCCCTGGAAGAGGCCTCAGTGTCCCGCCTGTGACCAGGCAGCTCAGAAAAGCCC
                ***************************** *************   **************
                              INS-4
human           TGGGAGCTCTGAGCCACYGTGAAGGTGGAAACGCGGCCCCTGGCCTCCCCTCTCCTGGAG
chimp           TGGGAGCTCTGAGCCACTGTGAAGGTGGAAACGCGGCCCCTGGCCTCCCCTCTCCTGGAG
gorilla         TGGGAGCTCTGAGCCACTGTGAAGGTGGAAACGCAGCCCCTGGCCTCCCCTCTCCTGGAG
orang           TGGGAGCTCTGAACCACTGTGAGGGTGGAAACGTGGCCCCTGGCCTCCCCTCTCCTGGAG
                ************ **** **** **********  *************************
                                                                    TH exon 14
human           GCTGCAGACTCTGCCCGCCAGTTGACGAGGGCTCTGCCGCTCTCCTCCCCAGGAGCTATG
chimp           GCTGCAGACTCTGCCTGCCAGTTGATGAGGGCTCTGCCGCTCTCCTCCCCAGGAGCTATG
gorilla         GCTGCAGACTCTGCCTGCCAGTTGACGAGGGCTCTGCCGCTCTCCTCCCCAGGAGCTATG
orang           GCTGCAGACTCTGCCCGCCAGTTGACGAGGGCTCTGCCGCTCTCCTCCCCAGGAGCTATG
                *************** ********* **********************************
                                                                     S  Y  A
                                                                       INS-5
human           CCTCACGCATCCAGCGCCCCTTCTCCGTGAAGTTCGACCCGTACACGCTGGCCATCGAYG
chimp           CCTCACGCATCCAGCGCCCCTTCTCCGTGAAGTTCGACCCGTACACGCTGGCCATCGACG
gorilla         CCTCACGCATCCAGCGCCCCTTCTCCGTGAAGTTCGACCCGTACACGCTGGCCATCGACG
orang           CCTCACGCATCCAGCGCCCCTTCTCCGTGAAGTTCGACCCATACACGCTGGCCATCGACG
                **************************************** ***************** *
                  S  R  I  Q  R  P  F  S  V  K  F  D  P  Y  T  L  A  I  D  V

human           TGCTGGACAGCCCCCAGGCCGTGCGGCGCTCCCTGGAGGGTGTCCAGGATGAGCTGGACA
chimp           TGCTGGACAGCCCCCAGGCCGTGCGGCGCTCCCTGGAGGGTGTCCAGGATGAGCTGGACA
gorilla         TGCTGGACAGCCCCCAGGCCGTGCGGCGCTCCCTGGAGGGTGTCCAGGATGAGCTGGACA
orang           TGCTGGACAGCCCCCAGGCCGTGCGGCGCTCCCTGGAGGGTGTCCAGGACGAGCTGGACA
                ************************************************* **********
                  L  D  S  P  Q  A  V  R  R  S  L  E  G  V  Q  D  E  L  D  T

human           CCCTTGCCCATGCGCTGAGTGCCATTGGCTAGGTGCACGGCGTCCCTGAGGGCCCTTCCC
chimp           CCCTTGCCCATGCGCTGAGTGCCATTGGCTAGGTGCACGGCGTCCCTGAGGGCCCTTCCC
gorilla         CCCTTGCCCATGCGCTGAGTGCCATTGGCTAGGTGCACGGCGTCCCTGAGGGCCCTTCCC
orang           CCCTTGCCCATGCGCTGAGTGCCATTGGCTAGGTGCAGGGCACCCCCGAGGGCCCTTCCC
                ************************************* ***  *** *************
                  L  A  H  A  L  S  A  I  G

human           AACCTCCCCTGGTCCTGCACTGTCCCGGAGCTCAGGCCCTGGTGAGGGGCTGGGTCCCGG
chimp           AACCTCCCCTGGTCCTGCACTGTCCCGGAGCTCAGGCCCTGGTGAGGGGCTGGGTCCCGG
gorilla         AACCTCCCC-GGTCCTGCACTGTCCCGGAGCTCAGGCCCTGGTGAGGGGCTGGGTCCCGG
orang           AACCTCCCCTGGTCCTGCACTGTCCCGGAGATCAGGCCCTGGTGAGGGGCTGGGTCCCGG
                ********* ******************** *****************************

human           GTGCCCCCCATGCCCTCCCTGCTGCCAGGCTCCCACTGCCCCTGCACCTGCTTCTCAGCG
chimp           GTGCCCCCAC----CTCCCTGCTGCCAGGCTCCCGCTGCCCCTGCACCTGCTTCTCAGCG
gorilla         ATGCCCCCAC??????????????????????????????????????????????????
orang           GTGCCCCCCATGCCCTCCCTGCTGCCAGGCTCCCCCTGCCCCTGCACCTGCTTCTCAGCG
                 *******      ******************** *************************

human           CAACAGCTGTGTGTGCCCGTGGTGAGGTTGTGCTGCCTGTGGTGAGGTCCTGTCCTGGCT
chimp           CAACAGCTGTGTGTGCCCGTGGTGAGGTTGTGCTGCCTGTGGTGAGGTCCTGTCCTGGCT
gorilla         ??????????????????????????????????GCCTGTGGTGAGGTCCTGTCCTGGCT
orang           CAACAGCTGTGTGTGCCCGTGGTGAGGTTGTGCTGCCTGTGGTGAGGTCCTGTCCTGGCT
                ************************************************************

human           CCCAGGGTCCTGGGGGCTGCTGCACTGCCCTCCGCCCTTCCCTGACACTGTCTGCTGCCC
chimp           CCCAGGGTCCTGGGGGCTGCTGCACTGCCCTCTCCCCTTCCCTGACACTGTCTGCTGCCC
gorilla         CCCAGGGTCCTGGGGGCTGCTGCACTGCCCTCCCCCCTTCCCTGCCACTGTCTGCTGCCC
orang           CCCAGGGTCCTGGGGGCTGCTGCACTGCCCTCTGCCCTTCCCTGACACCGTCTGCTGCCC
                ********************************  ********** *** ***********
                     INS-6
human           CAATCACCRTCACAATAAAAGAAACTGTGGTCTCTACACCTGCCTGGCCCCACATCTGTG
chimp           CAGCCACCATCACAATAAAAGAAAGTGTGGTCTCTACACCTGCCTGGCCCCACGTCTGTG
gorilla         CAATCACCGTCACAATAAAAGAAAGTGTGGTCTCTACACCTGCCTGGCCCCACGTCTGTG
orang           CAATCACCGTCACAATAAAAGAAAGTGTGATCTCTGCACCTGCCTGGCCCCACGTCTGTG
                **  **** *************** **** ***** ***************** ******
                    INS-7
human           CCACAGASACAGACCCTGGGATCCTCAGACTCCCACACCCCCACCCCAGCCTCACTCAGA
chimp           CCACAGAGACAGACCCTGGGATCCTCAGGCCCCCACATCCCCACCCCAGCCTCACTCAGA
gorilla         CCACAGAGACAGACCCTGGGATCCCCAGGCTCCCACACCCCCACCCCAGCCTCACTCAGA
orang           CCGCAGAGACAGACCCTGGGATCCTCAGGCTCCCACACCCCCACCCCAGCCTCACTCAGA
                ** **** **************** *** * ****** **********************

human           GGTTTCGCCCTGGCCTCCTTCCTCCTCTGGGAGATGGCTGGCCGCCCTGGCCAGGCAGCT
chimp           GCTTTCGCCCTGGCCTCCTTCCTCCTCTGGGAGGTGGCTGGCCGCCCTGGCCAGGCAGCT
gorilla         GCTTTCGCCCTGGCCTCCTTCCTCCTCTGGGAGATGGCTGGCCGCCCTGGCCAGGCAGCT
orang           GGTTTTGCCCTGGCCCCCTCCGTCCTCTGGGAGATGGCTGGCTGCCCTGGCCAGGCAGCT
                * *** ********* *** * *********** ******** *****************

human           GGCCCCTCCGGGCCTGGTTTCCCCGCTCACCCTGAGGCCCCGCCCAGCTCTGAGCCCCAA
chimp           GGCCCCTCCGGGCCTGGTTTCCCCGCTCACCCTGAGGCCCCGCCCAGCTCTGAGCCCCAA
gorilla         GGCCCCTCCGGGCCTGGTTTCCCCGCTCACCCTGAGGCCCCGCCCAGCTCTGAGCCCCGA
orang           GGCCCCTCCAGGCCTGGTTGCCCCGCTCACCCTGAGGCCCCGCCCAGCTCTGAGCCCCAA
                ********* ********* ************************************** *

human           GCAGCTCCAGAGGCTCGGGCACCCTGGCCGAGCTGCCCCATCTCCGTGGGGTGCCCTCCC
chimp           GCAGCTCCAGAGGCTCGGGCACCCTGGCTGAGCTGCCCCATCTCCGTGGGGTGCCCTCCC
gorilla         GCAGCTCCAGAGGCTCGGGCACCCTGGCCGAGCTGCCCCATCTCCGTGGGGTGCCCTCCC
orang           GCAGCTCCAGAGGCTCAGGCACCCTGGCTGAGCTGCCCCATCTCCGTGGGGTGCCCTCCC
                **************** *********** *******************************
                                                           INS-9
human           AAGGTGGGGAGCCACGTGACAGTGGGAGGGCCTCTCTCAGGCCTGGMAGGGAGCAGGGGT
chimp           AAGGTGGGGAGCCGAGTGACCATGGGAGGGCCTCTCTCAGGCCTGGCAGGGAGCAGGGGT
gorilla         AAGGTGGGGAGCCGAGTGACAGTGGGAGGGCCTCTCTCAGGCCTGGCAGGGAGCAGGGGT
orang           AAGGTGGGAAGCCAAGTG-------------------------------GGAGCAGGGGT
                ******** ****  ***                               ***********

human           CACAAACTGTGCTGGCTGGGGGTGGTCTCAGAGGTGGGCCTGCAGGCCTAACCCTCCCTG
chimp           CACAAACTGTGCTGGCTGGGGGTGGCCTCAGAGGTGGGCCTGCAGGCCTAACCCTCCCTG
gorilla         CACAAACT--GCTGGCTGGGGCTGGTCTCAGAGGTGGGCCTGCAGGCCTAACCCTCCCTG
orang           CACAA-CTGTGCTGGCTGGGGGTGGTCTCAGAGGTGGGCCTGCAGGCCTAACCCTCCCTG
                ***** **  *********** *** **********************************

human           CTGACAGGGCTCCCAGCCCTTGAGAGAAACAGGGATGGAGGAACAGCTGCCCTGATGCCC
chimp           CTGACAGGGCTCCCAGCCCTTGAGAGAAACAGGGATGGAGGAACAGCTGCCCCGATGCCC
gorilla         CGGACAGGGCTCCCAGCCCTTGAGAGAAACAGGGATGGAGGAACAGCTTCCCCGATGCCC
orang           CTGACGGGGCTCCCAGCCCTTGAGAGGAGCAGGGATGGAGGAACAGCTGCCCCAATGCCC
                * *** ******************** * ******************* ***  ******

human           TCACCCACCCGGAGCAGGCCCTGCGAACCAAGGGGAACCTCAGTGTGGCCCCCAGCATGT
chimp           TCACCCACCCGGAGCAGGCCCTGTGAACCAACGGGAACCTCAGTGTGGCCCCCAGCATGT
gorilla         TCACCCACCCGGAGCAGGCCCTGCGAACCAAGGGGAACCTCAGTGTGGCCCCCAGCATGT
orang           TCACCCACCCGGAGCAGGCCCTGCGAACCAAGGGGGACCTCAGCGTGACCCCCAGCATGT
                *********************** ******* *** ******* *** ************

human           GTGCTGATGGGGAGGGTCTGGCTGAGCTGGTGCCCAGGCAGATGGTCTGGGCCTGTCTCC
chimp           GTGCTGATGGGGAGGGTCTGGCTGAGCTGGTGCCCAGGCAGATGGTCTGGGCCTATCTCC
gorilla         GTGCTGATGGGGAGGGTCTGGCTGAGCTGGTGCCCAGGCAGATGGTCTGGGCCTGTCTCC
orang           GTGCTGATGGGGAGGGTCTGGCTGAGCTGGTGCCCAGGCAGATGGTCTGGGCCTGTCTCC
                ****************************************************** *****

human           CCAGCGAGGCAGGATGGGGGCTGGATTTCAGACTCTGTAAGATGCCCCTGGCTTACTCGA
chimp           CCAGTGAGGCAGGCTGGGGGCTGGATTTCA--CTCTGTAACATGCCCCTGGCTTACTCGA
gorilla         CCAGCGAGGCAGGCTGGGGGCTGGATTTCAGACTCTGTAAGATGCCCCTGGCTTACTCGA
orang           CCAGC???????????????????????????????????????????????????????
                **** ******** ****************  ******** *******************

human           GGGGCCTGGACATTGCCCTCCAGAGAGAGCACCCAACACCCTCCAGGCTTGACCGGCCAG
chimp           GGGGCCTGGACAT---CCTCCAGAGAGAGCACCCAACACCCTCCAGGCTTGACCGGCCAG
gorilla         GGGACCTGGACATTGCCCTCCAGAGAGAGCACCCAACACCCTCCAGGCTTGACCGGCCAG
orang           ????????????????????????????????????????????????????????????
                *** *********   ********************************************

human           GGTGTCCCCTTCCTACCTTGGAGAGAGCAGCCCCAGGGCATCCTGCAGGGGGTGCTGGGA
chimp           GGTGCCCCCTTCCTACCTTGGAGAGAGCAGCCCCAGGGCGTCCTGCAAGGGGTGCTGGGA
gorilla         GGTGCCCCCTTCCTACCTTGGAGAGAGCAGCCCCAGGGCATCCTGCAGGGGGTGCTGGGA
orang           ????????????????????????????????????????????????????????????
                **** ********************************** ******* ************
                                                              INS-10
human           CACCAGCTGGCCTTCAAGGTCTCTGCCTCCCTCCAGCCACCCCACTACAYGCTGCTGGGA
chimp           CACCAGCTGGCCTTCAAGGCCTCTGCCTCCCTCCAGCCACCCCACTACACCCTGCTGGGA
gorilla         CACCAGCTGGCCTTCAAGGCCTCTGCCTCCCTCCAGCCACCCCACTACACCCTGCTGGGA
orang           ????????????????????????????????????????????????????????????
                ******************* *****************************  *********
                               INS-11
human           TCCTGGATCTCAGCTCCCYGGCCGACAACACTGGCAAACTCCTACTCATCCACGAAGGCC
chimp           TCCTGGATCTCAGCTCCCCGGCCGACAACCCTGGCAAACTCCTACTCATCCACAAAGGCC
gorilla         TCCTGGATCTCAGCTCCCCGCCCGACAACCCTGGCAAACTCCTACTCATCCACGAAGGCC
orang           ????????????????????????????????????????????????????????????
                ****************** * ******** *********************** ******

human           CTCCTGGGCATGGTGGTCCTTCCCAGCCTGGCAGTCTGTTCCTCACACACCTTGTTAGTG
chimp           CTCCTGGGCATGGCGGTCCTTCCCAGCCTGGCAGTCTGTTCCTCACACACCTTGTCGGTG
gorilla         CTCCCGGGCATGGCGGTCCTTCCCGGCCTGGCAGTCTGTTCCTCACACACCTTGTCGGTG
orang           ????????????????????????????????????????????????????????????
                **** ******** ********** ******************************  ***

human           CCCAGCCCCTGAGGTTGCAGCTGGGGGTGTCTCTGAAGGGCTGTGAGCCCCCAGGAAGCC
chimp           CCCAGCCCCTGAGGTTGCAACTGGGGGTGTCTCTGAAGGGCTGTGAGCCCCAAGGAAGCC
gorilla         CCCAGCCCCTGAGGTTGCAACTGGGGGTGTCTCTGAAGGGCTGTGAGCCCCAAGGAAGCC
orang           ????????????????????????????????????????????????????????????
                ******************* ******************************* ********

human           CTGGGGAAGTGCCTGCCTTGCCTCCCCCCGGCCCTGCCAGCGCCTGGCTCTGCCCTCCTA
chimp           CTGGGGAAGTGCCTGCCTTGCCTCCCCCCGGCCCTGCCAGCCCCTGGCTCTGCCCTCCTA
gorilla         CTGGGGAAGTGCCTGCCTTGCCTCCCCCCGGCCCTGCCAGCCCCTGGCTCTGCCCTCCTA
orang           ???????AGTGCCTGCCTTGCCTCCCCCCGGCCCTGCCAGCCCCTGGCTCTGCCCTCCTA
                ***************************************** ******************
                          INS-12
human           CCTGGGCTCCCCCYATCCAGCCTCCCTCCCTACACACTCCTCTCAAGGAGGCACCCATGT
chimp           CCTGGGCTCCCCCCATCCAGCCTCCCTCCCTACACACTCCTCTTAAGGAGGCACCCATGT
gorilla         CCTGGGCTCCCCCCATCCAGCCTCCCTCCCTACACACTCCTCTTAAGGAGGCACCCATGT
orang           CCTGGGTTCCCCCCATCCAGCCTCCCTCCCTACACACTCCTCTTAAGGAGGCACCCACGT
                ****** ****** ***************************** ************* **

human           CCTCTCCAGCTGCCGGGCCTCAGAGCACTGTGGCGTCCTGGGGCAGCCACCGCATGTCCT
chimp           CTTCTCCAGCTGCCGGGCCTCAGAGCACTGTGGTGTCCTGGGGCAGCCACCGCATGTCCT
gorilla         CTTCTCCAGCTGCCGGGCCTCAGAGCACTGTGGTGTCCTGGGGCAGCCACCGCATGTCCT
orang           CTTCTCCAGCTGCCGGGCCTCAGAGCACGGTGGCGTCCTGGGGCAGCCACCACATGTCCT
                * ************************** **** ***************** ********
                                         INS-14
human           GCTGTGGCATGGCTCAGGGTGGAAAGGGYGGAAGGGAGGGGTCCTGCAGATAGCTGGTGC
chimp           GCTGTGGCATGGCTCAGGGTGGAAAGGGTGGAAGGGAGGGGCCCTGCAGATAGCTGGTGC
gorilla         GCTGTGGCATAGCTCAGGGTGGAAAGGGCGGAAGGGAGGGGCCCTGCAGATAGCTGGTGC
orang           GCTGTGGCATGGCTCAGAGTGGAAAGGGTGGGAGGGAGGGGTCCTGCAGATAGCTGGTGC
                ********** ****** ********** ** ********* ******************

human           CCACTACCAAACCCGCTCGGGGCAGGAGAGCCAAAGGCTGGGTGTGTGCAGAGCGGCCCC
chimp           CCACTACCAAACCCGCTCGGGGCAGGAGAGCCTAAGGCTGGGTGTGTGCAGAGTGGCCCC
gorilla         CCACTACCAAACCCGCTCTGGGCAGGAGAACCTAAGGCTGGGTGTGTGCAGAGTGGCCCT
orang           CCACTACCAAACCCGCTCGGGGCAGGAGAGCCTAAGGCTGGGTGTGTGCAGGGCAGCCCC
                ****************** ********** ** ****************** *  **** 
                             INS-16
human           GAGAGGTTCCGAGGCTRAGGCCAGGGTGGGACATAGGGATGCGAGGGGCCGGGGCACAGG
chimp           GAGAGGTTCTGAGGCTGAGGCCAGGGTGGGACATAGGGATGTGAGGGGCCAGGGCACAGG
gorilla         GAGAGGTTCTGAGGCTGAGGCCAGGGTGGGACATAGGGATGCGAGGGGCCGGGGCACAGG
orang           GAGAGGTTCTGAGGCTGAGGCCAGGGTGGGACATAGGGATGCGAGCAGCCGGGGCACAGG
                ********* ****** ************************ ***  *** *********

human           ATACTCCAACCTGCCTGCCCCCATGGT--------------CTCATCCTCCTGCTTCTGG
chimp           ATACTCCAACCTGCCTGCCCCCATTGTTGGAGCAGGATGCTCCAACCCTCCTGCTTCTGG
gorilla         ATACTCCAACCTGTCTGCCCCCATGGT--------------CTCACCCTCCTGCTTCTGG
orang           ATATTCCAATCTGCCTGCCCCCATGGT--------------CTCACCCTCCTGCTTCTGG
                *** ***** *** ********** **              *  * **************

human           GACCTCCTGATCCTGCCCCTGGTGCTAAGAGGCAGGTAGGGGCTGCAGGCAGCAGGGCTC
chimp           GACCTCCTGATCCTGCCCCTGGTGCTAAGAGGCAGGTAGGGGCTGCGGGCAGCAGGGCTC
gorilla         GACCTCCTGATCCTGCCCCTGGTGCTAAGAGGCAGGTAGGGGCTGCGGGCAGCAGGGCTC
orang           GACCTCCTGATCCTGCGCCTGGTGCTAAGAGTCAGGTAGGGGCTGCGGGCAGCAGGGCTC
                **************** ************** ************** *************

human           GGAGCCCATGCCCCCTCACCATGGGTCAGGCTGGACCTCCAGGTGCCTGTTCTGGGGAGC
chimp           GGAGCCCATGCCCCCTCACCATGGGTCAGGCTGGACCTCCAGGTGCCTGTTCTGGGGAGC
gorilla         AGAGCCCATGCCCCCTCACCGTGGGTCAGGCTGGACCTCCAGGTGCCCGTTCTGGGGAGC
orang           AGAGCCCATGCCCCCTCACTATGGGTCAGACTGAACCTCCAGGTGCCTGTCCCGGGGGGC
                 ******************  ******** *** ************* ** * **** **

human           TGGGAGGGCCGGAGGGGTGTACCCCAGGGGCTCAGCCCAGATGACACTATGGGGGTGATG
chimp           TGGGAGGGCCGGAGGGGTGTACCCCAGGGGCTCAGCCCAGATGACACTATGGGGGTGATG
gorilla         TGGGAGGGCCGGAGGGGTGTACCCCAGGGGCTCAGCCCAGATGACACTATGGGGGTGATG
orang           TGGGAGGGCCGGAGGGGTGTACCCCAGGAGCTCAGCCCAGATGACACTATGGGGGTGATG
                **************************** *******************************
                   INS-17
human           GTGTCAWGGGACCTGGCCAGGAGAGGGGAGATGGGCTCCCAGAAGAGGAGTGGGGGCTGA
chimp           GTGTCGTGGGACCTGGCCAGGAGAGGGGAGATGGGCTCCCAGAAGAGGAGTAGGGGCTGA
gorilla         GTGTCATGGGACCTGGCCAGGAGAGGGGAGATGGGCTCCCAGAAGAGGAGTGGGGGCTGA
orang           GTGTCGTGGGACCTGGCCAGGAGAGGGGAGATGGGCTCCCAGAAGAGGAGTGGGGGCTGA
                *****  ******************************************** ********

human           GAGGGTGCCTGGGGGGCCAGGACGGAGCTGGGCCAGTGCACAGCTTCCCACACCTGCCCA
chimp           GAGGGTGCCTGGGGGGCCCGGACGGAGCTGGGCCAGTGCACAGCTTCCCACACCTGCCCA
gorilla         GAGGGTGCCTGGGGGGCCCGGACGGAGCTGGGCCAGTGCAYAGCTTCCCACACCTGCCCA
orang           GAGGATGCCTGGGGGGCCTGGACGGAGCTGGGCCAGTGCACAGCTTCCCACACCTGCCCA
                **** ************* ********************* *******************
                                INS-18        INS-19
human           CCCCCAGAGTCCTGCCGCCRCCCCCAGATCACAYGGAAGATGAGGTCCGAGTGGCCTGCT
chimp           CCCCCAGAGTCCTGCCGCCACCCCCAGATCACACGGAAGATGAGGTCCGAGTGGCCTGCT
gorilla         CCCCCAGAGTCCTGCCGCCACCCCCAGATCACACGGAAGATGAGGTCCGAGTGGCCTGCT
orang           CCCCCGGAGTCCTGCCGCCACCCCCAGATCACACGAAAGATGAGGTCCTAGTGGCCTGCT
                ***** ************* ************* * ************ ***********
                                        INS-20
human           GAGGACTTGCTGCTTGTCCCCAGGTCCYCAGGTCATGCCCTCCTTCTGCCACCCTGGGGA
chimp           GAGGACTTGCTGCTTGTCCCCGGGTCCCCGGGTCATGCCCTCCTTCTGCCACCCTCGGGA
gorilla         GAGGACTTGCTGCTTGTCCCCGGGTCCCCAGGTCATGCCCTCCTTCTGCCACCCTCGGGA
orang           GAGGACTTGCTGCTTGTCCCCGGGTCCCCGGGTCATGCCCGCCTTCTGCCACCGTGGGGA
                ********************* ***** * ********** ************ * ****

human           GCTGAGGGCCTCAGCTGGGGCTGCTGTCCTAAGGCAGGGTGGGAACTAGGCAGCCAGCAG
chimp           GCTGAGGGCCACAGCTGGGGCTGCTGTCCTACGGCGGGGTGGGAACTGGGCAGCCAGCAG
gorilla         GCTGAGGGCCTCAGCTGGGGCTGCTGTCCTAAGGCGGGGTGGGAACTGGGCAGCCAGCAG
orang           GCTGAGGGCCTCAGCTGGGGCTGCTGTCCTAACGTGGGGTGGGAACTGGGCAGCCAGCAG
                ********** ********************  *  *********** ************
                                     INS-21
human           GGAGGGGACCCCTCCCTCACTCCCMCTCTCCCACCCCCACCACCTTGGCCCATCCATGGC
chimp           GGAGGGGACCCCTCCCTCACTCCCACTGTACCACCCCCACCACCTTGGCCCATCCAT???
gorilla         GGAGGGGACCCCTCCCTCACTCCCACTCTCCCACCCCCACCACCTTGGC???????????
orang           GGAGGGGACCCCTCCCTCACTCCCACT------CCCCCACCACATTGGC???????????
                ************************ **      ********** *****           

Unsequenced minisatellite region

human           CCTCCAGCTCTCCTGGTCTAATGTGGAAAGTGGCCCAGGTGAGGGCTTTGCTCTCCTGGA
chimp           ????????????????????????????????????????GACGGCTTTGCTCTCCTGGA
gorilla         ????????????????????????????????????????GAGGGCTTTGCTCTCCTGGA
orang           ?????????????????????????????????????????????CCATCCTCTCCTGGA
                                                             *  * **********

human           GACATTTGCCCCCAGCTGTGAGCAGGGACAGGTCTGGCCACCGGGCCCCTGGTTAAGACT
chimp           GACATTTGCCCCCAGCTGTGAGCAGGGACAGGTCTGGCCACCGGGCCCCTGGTTAAGACT
gorilla         GACATTTGCCCCCAGCTGCGAGCAGGGACAGGTCTGGCCACCGGGCCCCTGGTTAAGACT
orang           GACATTTGCCCCCAGCTGCGAGCAGGGACAGGTCTGGCCACCAGGCCCCTGGTTAAGACT
                ****************** *********************** *****************

human           CTAATGACCCGCTGGTCCTGAGGAAGAGGTGCTGACGACCAAGGAGATCTTCCCACAGAC
chimp           CTAATGACCCGCTGGCCCTAAGGAAGAGGTGCTGACGACCAAGGAGATCTTCCCACAGAC
gorilla         CTAATGACCCGCTGGCCCTGAGGAAGAGGTGCTGACGACCAAGGAGATCTTCCCACAGAC
orang           CTAATGACCCGCTGGCCCTGAGGAAGAGGTGCTGATGACCAAGGAGATCTTCCCACAGAC
                *************** *** *************** ************************

human           CCAGCACCAGGGAAATGGTCCGGAAATTGCAGCCTCAGCCCCCAGCCATCTGCCGACCCC
chimp           CCAGCACCAGGGAAATGGTCCGGAAATTGCAGCCTCAGCCCCCAGCCATCTGCCGACCCC
gorilla         CCAGCACCAGGGAAATGGTCCGGAAATTGCAGCCTCAGCCCCCAGCCATCTGCCGACCCC
orang           CCAGCACCAGGGAAATGATCCGGAAATTGCAGCCTCAGCCCCCAGCCATCTGCCGACCCC
                ***************** ******************************************
                                                    INS-24 INS-25
human           CCCACCCCAGGCCCTAATGGGCCAGGCGGCAGGGGTTGASAGGTAGRGGAGATGGGCTCT
chimp           CCCACCCCAGGCCCTAATGGGCCAGGCGGCAGGGGTTGACAGGTAGGGGAGATGGGCTCT
gorilla         CCCACCCCAGGCCCTAATGGGCCAGGCGGCAGGGGTTGACAGGCAGGGGAGATGGGCTCT
orang           CCCACCCCAGGCCCTAATGGGCCAGGCGGCAGGGGTTGGCAGGTAGGGGAGATGGGCTCT
                **************************************  *** ** *************

human           GAGACTATAAAGCCAGCGGGGGCCCAGCAGCCCTCAGCCCTCCAGGACAGGCTGCATCAG
chimp           GAGACTATAAAGCCAGCGGGGGCCCAGCAGCCCTCAGCCCTCCAGGACAGGCTGCATCAG
gorilla         GAGACTATAAAGCCAGTGGGGACCCAGCAGCCCTCAGCCCTCCAGGACAGGCTGCATCAG
orang           GAGACTATAAAGCCAGTGGGGGCCCAGCAGCCCTCAGCCCTCCGGGACAGGCTGCATCAG
                **************** **** ********************* ****************
                                    INS-69                             INS-26
human           AAGAGGCCATCAAGCAGGTCTGTTGCTTCCAAGGGCCTTTGCGTCAGGTGGGCTCAGGR-----
chimp           AAGAGGCCATCAAGCAGGTCTG----TTCCAAGGGCCTTTGCGTCAGGTGGGCTCAGGG-----
gorilla         AAGAGGCCATCAAGCAGGTCTG----TTCCAAGGGCCTTTGCGTCAGGTGGGCTCAGGGCTGCC
orang           AAGAGGCCATCAAGCAGGTCTG----TTCCAAGGGCCTTTGCGTCAGGTGGGCTCAGGGCTGCC
                **********************    ********************************      

human           -----------TTCCAGGGTGGCTGGACCCCAGGCCCCAGCTCTGCAGCAGGGAGGACGT
chimp           -----------TTCCAGGGTGGCTGGACCCCAGGCCCCAGCTCTGCAGCAGGGAGGACGT
gorilla         CCACTTGGGGGTTCCAGGGTGGCTGGACCCCAGGCCCCAGCTCTGCAGCAGGGAGGACGT
orang           CCACTTGGGGGTTCCAGGGTGGCTGGACCCCAGGCTCCAGCTCTGCAGCTGGGAGGACGT
                           ************************ ************* **********

human           GGCTGGGCTCGTGAAGCATGTGGGGGTGAGCCCAGGGGCCCCAAGGCAGGGCACCTGGCC
chimp           GGCTGGGCTCTTGAAGCATGTGGGGGTGAGCCCAGGGGCCCCAAGGCAGGGCACCTGGCC
gorilla         GGCTGGGCTCTTGAAGCATGTGGGGGTGAGCCCAGGGGCCCCAAGGCAGGGCAACTGGCC
orang           GGCTGGGCTCTTGAAGCATTTGGGGGTGAGCCCAGGGGCCCCAGGGCAGGGCACCTGGCC
                ********** ******** *********************** ********* ******
                                       INS-27        INS-72
human           TTCAGCCTGCCTCAGCCCTGCCTGTCWCCCAGATCACTGTYCTTCTGCCATGGCCCTGTG
chimp           TTCAGCCGGCCTCAGCCCTGCCTGTCTCCCAGATCACTGTCCTTCTGCCATGGCCCTGTG
gorilla         TTCAGCCGGCCTCAGCCCTGCCTGTCTCCCAGATCACTGTCCTTCTGCCATGGCCCTGTG
orang           TTCAGCCGACCTCAGCTCTGCCTGTCTCCCAGATCACTGTCCTTCTGCCATGGCCCTGTG
                *******  ******* ********* ************* *******************
                                                                 M  A  L  W
                                     INS-70
human           GATGCGCCTCCTGCCCCTGCTGGCRCTGCTGGCCCTCTGGGGACCTGACCCAGCCGCAGC
chimp           GATGCGCCTCCTGCCCCTGCTGGTGCTGCTGGCCCTCTGGGGACCTGACCCAGCCTCGGC
gorilla         GATGCGCCTCCTGCCCCTGCTGGCGCTGCTGGCCCTCTGGGGACCTGACCCAGCCGCGGC
orang           GATGCGCCTCCTGCCCCTGCTGGCGCTGCTGGCCCTCTGGGGACCTGACCCGGCCCAGGC
                ***********************  ************************** ***   **
human            M  R  L  L  P  L  L  A  L  L  A  L  W  G  P  D  P  A  A  A
chimp                                 V                                S
gorilla                               A                                A
orang                                 A                                Q
Both variants lie within the INS signal peptide (shown by underline)

human           CTTTGTGAACCAACACCTGTGCGGCTCACACCTGGTGGAAGCTCTCTACCTAGTGTGCGG
chimp           CTTTGTGAACCAACACCTGTGCGGCTCCCACCTGGTGGAAGCTCTCTACCTAGTGTGCGG
gorilla         CTTTGTGAACCAACACCTGTGCGGCTCCCACCTGGTGGAAGCTCTCTACCTAGTGTGCGG
orang           CTTTGTGAACCAGCACCTGTGCGGCTCCCACCTGGTGGAAGCTCTCTACCTAGTGTGTGG
                ************ ************** ***************************** **
                 F  V  N  Q  H  L  C  G  S  H  L  V  E  A  L  Y  L  V  C  G

human           GGAACGAGGCTTCTTCTACACACCCAAGACCCGCCGGGAGGCAGAGGACCTGCAGGGTGA
chimp           GGAACGAGGCTTCTTCTACACACCCAAGACCCGCCGGGAGGCAGAGGACCTGCAGGGTGA
gorilla         GGAACGAGGCTTCTTCTACACACCCAAGACCCGCCGGGAGGCAGAGGACCTGCAGGGTGA
orang           GGAACGAGGCTTCTTCTACACACCCAAGACCCGCCGGGAGGCAGAGGACCTGCAGGGTGA
                ************************************************************
                 E  R  G  F  F  Y  T  P  K  T  R  R  E  A  E
                   INS-28
human           GCCAACYGCCCATTGCTGCCCCTGGCCGCCCCCAGCCACCCCCTGCTCCTGGCGCTCCCA
chimp           GCCAACCGCCCGTTGCTGCCCCTGGCCACCCCCAGCCACCCCCTGCTCCTGGCGCTCCCA
gorilla         GCCAACCGCCCGTTGCTGCCCCTGGCCGCCCCCAGCCACCCCCTGCTCCTGGCGCTCCCA
orang           GCCAACCGCCCCTTGCTGCCCCTGGTCGCCCCCAGCCATCCCCTGCTTCTGCCGCTCCCA
                ****** **** ************* * ********** ******** *** ********

human           CCCAGCATGGGCAGAAGGGGGCAGGAGGCTGCCACCCAGCAGGGGGTCAGGTGCACTTTT
chimp           CCCAGCATGGGCAGAAGGGGGCAGGAGGCTGCCACCCAGCAGGGGGTCAGGTGCACTTTT
gorilla         CCCAGCATGGGCAGAAGGGGGCAGGAGGCTGCCACCCAGCAGGGGGTCAGGTGTACTTTT
orang           CCCAGCATGGGCAGAAGGGGGCAGGAGGCTGCCACCCAGCAGGGGGTCAGGTGTACTTTT
                ***************************************************** ******

human           TTAAAAAGAA-----GTTCTCTTGGTCACGTCCTAAAAGTGACCAGCTCCCTGTGGCCCA
chimp           TAAAAAAGAAATGAAGTTCTCTTGGTCACATCCTAAAAGTGACCAGCTCCCTGTGGCCCA
gorilla         TTAAAAAGAAATGAAGTTCTCTTGGTCACGTCCTAAAAGTGACCAGCTCCCTGTGGCCCA
orang           TTAAAAAGAAATGAAGTTCTCTTGGTCACATCCTAAAAGTGACCAGTTCCCTGTGGCCCA
                * ********     ************** **************** *************

human           GTCAGAATCTCAGCCTGAGGACGGTGTTGGCTTCGGCAGCCCCGAGATACATCAGAGGGT
chimp           GTCAGAATCTCAGCCTGAGGACGGTGTTGGCTTCGGCAGCCCCGAGATACATCAGAGGGT
gorilla         GTCAGAGTCTCAGCCTGAGGACGGTGTTGGCTTCGGCAGCCCCGAGATACATCAGAGGGT
orang           TTCAGAAT-----------------GGGGGCTTCAGCAGCCCCGAGATACATCAGAGGGT
                 ***** *                 *  ****** *************************
                  INS-31
human           GGGCAYGCTCCTCCCTCCACTCGCCCCTCAAACAAATGCCCCGCAGCCCATTTCTCCACC
chimp           GGGCACGCTCCTCCCTCCACTCGCCCCTCAAACAAATGCCCCACAGCCCATTTCTCCACC
gorilla         GGGCACGCTCCTCCCTCCACTCGCCCCTCAAACAAATGCCCCGCAGCCCATTTCTCCACC
orang           GGGCACGCTCCTCCCTCCACTCGCCCCTCAAACAAATGCCCCACAGCCCATTTCTCCACC
                ***** ************************************ *****************

human           CTCATTTGATGACCGCAGATTCAAGTGTTTTGTTAAGTA-AAGTCCTGGGTGACCTGGGG
chimp           CTCATTTGATGACCGCAGATTCAAGTGTTTTGTTAAGTA-AAGTCCTGGGTGACCTGGGG
gorilla         CTCATTTGAAGACCTCAGATTCAAGTGTT-----------AAGTCCTGGGTGACCTGGGG
orang           CTCATTTGATGACCGCAGATTCAAGTGTTTTGTTAAGTACAAGTCCTGGGTGACCTGGGG
                ********* **** **************           ********************
                                         INS-32
human           TCACAGGGTGCCCCACGCTGCCTGCCTCYGGGCGAACACCCCATCACGCCCGGAGGAGGG
chimp           TCACAGGGTGCCCCACGCTGCCTGCCTCTGGGCGAACACCCCATCACGCCCTGAGGAGGG
gorilla         TCACAGGGTGCCCCACGCTGCCTGCCTCTGGGCGAACGCCCCATCACGCCCTGAGGAGGG
orang           TCACAGGGTGCCCCACGCTGCCTGCCTCTGGGCGAACGCCCCATCACGCCCTGAGGAGGA
                **************************** ******** ************* ******* 

human           CGTGGCTGCCTGCCTGAGTGGGCCAGACCCCTGTCGCCAGGCCTCACGGCAGCTCCATAG
chimp           CGTGGCTGCCTCCCTGAGTGGGCCAGACCCCTGTCGCCAGGCCTCACGGCAGCTCCATAG
gorilla         CGTGGCTGCCTGCCTGAGTGGGCCAGACCCCTGTCGCCAGGCCTCACGGCAGCTCCATAG
orang           CATGGCCGCCTGCCTGAGTGGGCCAGACCCCTGTCACCAGGCCTCACGGCAGCTCCGTAG
                * **** **** *********************** ******************** ***

human           TCAGGAGATGGGGAAGATGCTGGGGACAGGCCCTGGGGAGAAGTACTGGGATCACCTGTT
chimp           TCAGGAGATGGGGAAGATGCTGGGGACAGGCCCTGGGGAGAAGTACTGGGGCCACCTGTT
gorilla         TCAGGAGATGGGGAAGATGCTGGGGACAGGCCCTGGGGAGAAGTACTGGGGCCACCTGTT
orang           TCAGGAGATGGGGAAGATGCTGGGGACAGGCCCTGGGGAGGAGTACCGGGGGCACCTGTT
                **************************************** ***** ***  ********

human           CAGGCTCCCACTGTGACGCTGCCCCGGGGCGGGGGAAGGAGGTGGGACATGTGGGCGTTG
chimp           CAGGCTCCCGCTGTGACACCGCCCCGGGGCGGGGGAAGGAGGTAGGACATGTGGGCGTTG
gorilla         CAGGCTCCCGCTGTGACACCGCCCCGGGGCAGGGGAAGGAGGTAGGACATGTGGGCGTTG
orang           CAGGCTCCTGCTGTGACACTGCCCCGGGGCGGGGGAAGGAGGTAGGACATGTGGACCTTG
                ********  ******* * ********** ************ ********** * ***
                                  INS-34
human           GGGCCTGTAGGTCCACACCCASTGTGGGTGACCCTCCCTCTAACCTGGGTCCAGCCCGGC
chimp           GGGCCTGTAGGTCCACACCCAGTGTGGGTGACCCTCCCTCTAACCTGGGTCCAGCCCGGC
gorilla         GGGCCTGTAGGTCCACACCCAGTGTGGGTGACCCTCCCTCTAACCTGGGTCCAGCCCAGC
orang           GGGCCTGTAGGTCCACACCCAGTGTGGGTGACCTTCCCTATAATCTGGGTCCAGCCCGGC
                ********************* *********** ***** *** ************* **
                               INS-35
human           TGGAGATGGGTGGGAGTGYGACCTAGGGCTGGCGGGCAGGCGGGCACTGTGTCTCCCTGA
chimp           TGGAGATGGGTGGGAGTGCGACCTAGGGCTGGTGGGCAGGCGGGCACTGTCTCTCCCTGA
gorilla         TGGAGATGGGTGGGAGTGCAACCTAGGCCTGGTGGGCAGGCGGGCACTGTCTCTCCCTGA
orang           TGGAGATGGGTGGGAGTGCGACCTAGGGCTGGTGGGCAGGTGGGCAGTGTCTCTCCCTGA
                ******************  ******* **** ******* ***** *** *********
                                           INS-36                 INS-37
human           CTGTGTCCTCCTGTGTCCCTCTGCCTCGCCRCTGTTCCGGAACCTGCTCTGCGYGGCACG
chimp           CTGTGTCCTCCTGTGTCCCTCTGCCTCGCCGCTGTTCCGGAACCTGCTCTGCGCGGCACG
gorilla         CTGTGTCCTCCTGTGTCCCTCTGCCTCGCCGCTGTTCCGGAACCTGCTCTGCGCGGCGTG
orang           CTGTGTCCTCCTGTGTCCCTCTGCCTCACCGCTGTTCCGGAACCTGCTCTGCGCGGCACG
                *************************** ** ********************** ***  *

human           TCCTGGCAGTGGGGCAGGTGGAGCTGGGCGGGGGCCCTGGTGCAGGCAGCCTGCAGCCCT
chimp           CCCTGGCAGTGGGGCAGGTGGAGCTGGGCGGGGGCCCTGGTGCAGGCAGCCTGCAGCCCT
gorilla         CCCTGGCAGTGGGGCAGGTGGAGCTGGGCGGGGGCCCTGGTGCAGGCAGCCTGCAGCCCT
orang           CCCTGGCAGTGGGGCAGGTGGAGCTGGGCGGGGGCCCTGGTGCAGGCAGCCTGCAGCCCT
                 ***********************************************************
                        V  G  Q  V  E  L  G  G  G  P  G  A  G  S  L  Q  P  L

human           TGGCCCTGGAGGGGTCCCTGCAGAAGCGTGGCATTGTGGAACAATGCTGTACCAGCATCT
chimp           TGGCCCTGGAGGGGTCCCTGCAGAAGCGTGGTATCGTGGAACAATGCTGTACCAGCATCT
gorilla         TGGCCCTGGAGGGGTCCCTGCAGAAGCGTGGCATCGTGGAACAGTGCTGTACCAGCATCT
orang           TGGCCCTGGAGGGGTCCCTGCAGAAGCGTGGTATCGTGGAACAATGCTGTACCAGCATCT
                ******************************* ** ******** ****************
                  A  L  E  G  S  L  Q  K  R  G  I  V  E  Q  C  C  T  S  I  C
                                                        INS-38       INS-39
human           GCTCCCTCTACCAGCTGGAGAACTACTGCAACTAGACGCAGCCYGCAGGCAGCCCCMCAC
chimp           GCTCCCTCTACCAGCTGGAGAACTACTGCAACTAGATG----------------------
gorilla         GCTCCCTCTACCAGCTGGAGAACTACTGCAACTAGATGCAGCCCGCAGGCAGCCCCACAC
orang           GCTCCCTCTACCAGCTGGAGAACTACTGCAACTAGATGTGGCCGGCAGGCGGCCCCGCAC
                ************************************ *                      
                  S  L  Y  Q  L  E  N  Y  C  N

human           CCGCCGCCTCCTGCACCGAGAGAGATGGAATAAAGCCCTTGAACCAGCCCTGCTGTGCCG
chimp           ---------------------------GAATAAAGCCCTTGAACCAGCCCTGCTGTGCCG
gorilla         CCTCCGCCTCCTGCACCGAGAGACATGGAATAAAGCCCCTGAACCAGCCCTGCTGTGCCG
orang           CCTCCGCCTCCTGCACCGAGAGAGATGGAATAAAGCCCTTGAACCAGCCCTGCTGTGCCG
                                           *********** *********************

human           TCTGTGTGTCTTGGGGGCCCTGGGCCAAGCCCCACTTCCCGGCACTGTTGTGAGCCCCTC
chimp           TCTGTGTGTCTTGGGGGCCCTGGGCCAAGCCCCACTTCCCGGCACTGTTGTGAGCCCCTC
gorilla         TCTGTGTGTCTTGGGGGCCCTGGGCCAAGCCCCACTTCCCGGCACTGTTGTGAGCCCCTC
orang           TCTGTGTGTCTTGGGGGCCCTGGGCCAAGCCCCACTTCCCGGCACTGTTGTGAGCCCCTC
                ************************************************************

human           CCAGCTCTCTCCACGCTCTCTGGGTGCCCACAGGTGCCAACGCCGGCCAGGCCCAGCATG
chimp           CCAGCTCTCTCCATGCTCTCTGGGTGCCCACAGGTGCCAATGCCGGCCAGGCCCAGCATG
gorilla         CCAGCTCTCTCCATGCTCTCTGGGTGCCCACAGGTGCCAACGCCAGCCAGGCCCAGCATG
orang           CCAGCTCTCTCCACGCTCTCTGGGTGCCCACAGGTGCCAACGCCGGCCAGGCCCAGCATG
                ************* ************************** *** ***************
                                            INS-40
human           CAGTGGCTCTCCCCAAAGCGGCCATGCCTGTYGGCTGCCTGCTGCCCCCACCCTGTGGCT
chimp           CAGTGGCTCTCCCCAAAGCGGCCATGCCTGTCGGCTGCCTGCTACCCCCACCCTGTGGCT
gorilla         CAGTGGCTCTCCCCAAAGCGGCCATGCCTGTCGGCTGCCTGCTACCCCCACCCTGTGGCT
orang           CAGTGGCTCTCCCCAAAGCGGCGATGCCTGTCGGCTGCCTGCT------ACCCTGGGGCT
                ********************** ******** ***********      ****** ****
                                 INS-41                  INS-42
human           CAGGGTCCAGTATGGGAGCTKCGGGGGTCTCTGAGGGGCCAGGGRTGGTGGGGCCACTGA
chimp           CAGGGTCCAGTATGGGAGCTGCGGGGGTCTCTCAGGGGCCAGGGGTGGTGCAGCCACTGA
gorilla         CAGGGTCCAGTATGGGAGCTGCGGGGGTCTCTGAGGGGCCAGGGGTGGTGGGGCCACTGA
orang           CAGAGTCCAGTGTCGGAGCTGCGGGGGTCTCTGAGGGGCC-GGGGTGGTGGGGCCACTGA
                *** ******* * ****** *********** ******* *** *****  ********

human           GAAGTGACTTCTTGTTCAGTAGCTCTGGACTCTTGGAGTCCCCAGAGACCTTGTTCAGGA
chimp           GAAATGACTTCTTGTTCAGTAGCTCTGGACTCTTGGAGTCCCCAGAGACCTTGTTCAGGA
gorilla         GAAATGACTTCTTGTTCAGTAGCTCTGGACTCTTGGAGTCCCCAGAGACCTTGTTCAGGA
orang           GAAATGACTTCTTGTTCAGTAGCTCTGGACCCTCGGAGTCCCCAGAGACCTTGTTCAGGA
                *** ************************** ** **************************

human           AAGGGAATGAGAACATTCCAGCAATTTTCCCCCCACCTAGCCCTCCCAGGTTCTATTTTT
chimp           AAGGGAATGAGAACATTCCAGCAATTTTCCCCCCACCTAGCCCTCCCAGGTTCTATTTTT
gorilla         AAGGGAATGAGAACATTCCAGCAATTTTCCCCCCACCTAGCCCTCCCAGGTTCTATTTTT
orang           AAGGGAATGAGAACATTCCAGCAATTTTCCCCCCACCTAGCCCTCCCAGGTTCTATTTTT
                ************************************************************

human           AGAGTTATTTCTGATGGAGTCCCTGTGGAGGGAGGAGGCTGGGCTGAGGGAGGGGGTCCT
chimp           AGAGTTATTTCTGATGGAGTCCCTGTGGAGGGAGGAGGCTGGGCTGAGGGAGGGGGTCCT
gorilla         AGATTTATTTCTGATGGAGTCCCTGTGGAGGGAGGAGGCTGGGCTGAGGGAGGGGGTCCT
orang           AGAGTTATTTCTGATGGAGTCCCTATGGAGGAAGGAGGATGGGCTGAGGGAGGGGGTCCT
                *** ******************** ****** ****** *********************

human           GCAGGGCGGGGGGCTGGGAAGGTGGGGAGAGGCTGCCGAGAGCCACCCGCTATCCCCAGC
chimp           GCAGGGCAGGGGGCTGGGAAGGTGGGGAGAGGCTGCCGAGAGCCACCCGCTATCCCCAGC
gorilla         GCAGGGCGGGGGGCTGGGAAGGTGGGGAGAGGCTGCTGAGAGCCACCCGCTATCCCCAGC
orang           GCAGGGCAGGGGGCTGGGAAGGTGGGGAGAGGCTGCCGAGAGCCACCCGCTATCCCCAGC
                ******* **************************** ***********************

human           TCTGGGCAGCCCCGGGACAGTCACACACCCTGGCCTCGCGGCCCAAGCTGGCAGCCGTCT
chimp           TCTGGGCAGCCCCGGGACAGTCACACACCCTGGCCTCGCGGCCCAAGCTGGCAGCCGTCT
gorilla         TCTGGGCAGCCCTGGGACAGTCACACACCCTGGCCTCGCGGCCCAAGCTGGCAGCCGTCT
orang           TCCGGGCAGCCCCGGGACAGTCACACACCCTGGCCTCGCGGCCCAAGCTGGCAGCCATCT
                ** ********* ******************************************* ***

human           GCAGCCACAG--TATGCCAGCCCAGGTCCAGCCAGACACCTGAGGGACCCACTGGTGCCT
chimp           GCAGCCACAGCTTATGCCAGCCCAGGTCCAGCCAGACACCTGAGGGACCCACTGGTGCCT
gorilla         GCAGCCACAGCTTATGCCAGCCCAGGTCCAGCCAGACACCTGAGGGACCCACTGGTGCCT
orang           GCAGCCACAGCTTATGCCAGCCCAGGTCCAGCCAGACACCTGAGGGACCCACTGGTGCCT
                **********  ************************************************

human           TGGAGGAAGCAGGAGAGGTCAGATGGCACCATGAGCTGGGGCAGGTGCAGGGACCGTGGC
chimp           TGGAGGAAGCAGGAGAGGTCAGATGGCACCATGAGCTGGGGCAGGTGCAGGGACCGTGGC
gorilla         TGGAGGAAGCAGGAGAGGTCAGATGGCACCATGAGCTGGGGCAGGTGCAGGGACCGTGGC
orang           TGGAGGAAGCAGGAGAGCTCGGACGGCACCATGAGCCGGGGCAGGTGCAGGGACCGTGGC
                ***************** ** ** ************ ***********************

human           AGCACCTGGCAGGGCCTCAGAACCCATGCCTTGGGCACCCCGGCCATGAGGCCCTGAGGA
chimp           AGCACCGGGCAGGGCCTCAGAACCCATGCCTTGGGCACCCTGGCCATAAGGCCCTGAGGA
gorilla         AGCACCGGGCAGGGCCTCAGAACCCATGCCTTGGGCACCCTGACCATAAGGCCCTGAGGA
orang           AGCACTGGGCAGGGCCTCAGAACCCACGCCTTGGGCACCCTGGCCATAAGGCCCTGAGGG
                *****  ******************* ************* * **** *********** 
                                                                INS-43
human           TTGCAGCCCAGGAGAAGCAGGGAACCGCCAGGGCCACAGGGGCAGAGACCASGGCCAGGG
chimp           TTGCAGCCCAGGAGAAGCAGGGAACCGCCAGGGCCACAAGGGCAGAGACCAGGGCCAGGG
gorilla         TTGCAGCCCAGGAGAACCAGGGAACCGCCAGGGCCACAAGGGCAGAGACCAGGGCCAGGG
orang           TTGCAGCCCAGGAGGACCAGGGAACCGCCAGGGCCACAGGGGCAGAGACCAGGGCCAGGG
                ************** * ********************* ************ ********
                                  INS-45
human           TCCCCCTGCAGCCCCTTAGCCYACCCCCTCCCAGTAAGCAGGGCTGCTTGGCTGGCTTCC
chimp           TCCCCCTGCAGCCCCTTAGCCCACTGCCTCCCAGTAAGCAGGGCTGCTTGGCTGGCTTCC
gorilla         TCCCCCTGCAGCCCCTTAGCCCACCGCCTCCCAGTAAGCAGGGCTGCTTGGCTGGCTTCC
orang           TCCCCCTGCAGCCCCTTAGCCCACCCCCTCCCAGTAAGCAGGGCTGCTTGGCTGGCTTCC
                ********************* **  **********************************

human           TTTGCTACAGACCTGCTGCTCACCCAGAAGGGCCCACGGGCCCTGGTGACAAGGTCGTTG
chimp           TTGGCTACAGACCTGCTGCTCACCCAGAAGGGCCCACGGGCCCTGGTGACAAGGTCGTTG
gorilla         TTTGCTACAGACCTGCTGCTCACCCAGAAGGGCCCACGGGCCCTGGTGACAAGGTTGTTG
orang           TTTGCTGCAGACCTGCTGCTCACCCAGAAGGGCCCACGGGCCCTGGTGACAAGGTCGTTC
                ** *** ************************************************ *** 

human           TGGCTCCAGGTCCTTGGGGGTCCTGACACAGAGCCTCTTCTGCAGCACCCCTGAGGACAG
chimp           TGGCTCCAGGTCCTTGGGGGTCCTGACACAGAGCCTCTTCTTCCGCACCC-TGAGGACAG
gorilla         TGGCTCCAGGTCCTTGGGGGTCCTGACACAGAGCCTCTTCTGCAGCACCCCTGAGGACAG
orang           TGGCTCCAGGTCCTTGGGGTTCCTGACACGGAGCCTTTTCTTCAGCACCCCTGAGGACAG
                ******************* ********* ****** **** * ****** *********

human           GGTGGCTCCGCTGGGCACCCAGCCTAGTGGGCAGACGAGAACCTAGGGGCTGCCTGGGCC
chimp           GGTGGCTCCGCTGGGCACCCAGCCTAGTGGGCAGACGAGAACCTAGGGGCTGCCTGGGCC
gorilla         GGTGGCTCCGCTGGGCACCCAGCCTAGTGGGCAGATGAGAACCTAGGGGCTGCCTGGGCC
orang           GGTGGCTCCGCTGGGCACCCAGCCTAGTGGGCAGACGAGAACCTACGGGCTGCCTGGGCC
                *********************************** ********* **************

human           TACTGTGGCCTGGGAGGTCAGCGGGTGACCCTAGCTACCCTGTGGCTGGGCCAGTCTGCC
chimp           TACTGTGGCCTGGGAGGTCAGCGGGTGACCCTAGCTACCCTGTGGCTGGGCCAGTCTGCC
gorilla         TACTGTGGCCTGGGAGGTCAGCGGGTGACCCTAGCTACCCTGTGGCTGGGCCAGTCTGCC
orang           TACTGTGGCCTGGGAGGTCAGCGGGTGACCCTAGCTACCCTGTGGCTGGGCCAGCCTGCC
                ****************************************************** *****
                                                            INS-49     INS-71
human           TGCCACCCAGGCCAAACCAATCTGCACCTTTCCTGAGAGCTCCACCCWGGGCTGGGCTGG
chimp           TGCCACCCAGGCCAAACCAATCTGCACCTTTCCTGAGAGCACCACCCAGGGCTGGGCTGG
gorilla         TGCCACCCAGGCCAAACCAATCTGCACCTTTCCTGAGAGCTCCACCCAGGGCTGGGCTGG
orang           TGCCACCCAGGCCAAACCAATCTGCACCTTTCCTGAGAGCTCCACCCAGGGCTGGGCTGG
                **************************************** ****** ************

human           GGATGGCTGGGCCTGGGGCTGGCATGGGCTGTGGCTGCAGACCACTGCCAGCTTGGGCCT
chimp           GGATGGCTGGGCCTGGGGCTGGCATGGGCTGTGGCTGCAGACCACTGCCAGCTTGGGCCT
gorilla         GGATGGCTGGGCCTGGGGCTGGCATGCGCTGTGGCTGCAGACCACTGCCAGCTTGGGCCT
orang           GGATGGCTGGGCCTGGGGCTGGCATAGGCTGTGGCTGCAGACCACTGCCAGCTTGGGCCT
                *************************  *********************************

human           CGAGGCCAGGAGCTCACCC-TCCAGCTGGGGACCTGGCCACTGGGGCAGCCCTGTTCCTG
chimp           CGAGGCCAGGAGCTCACCCCTCCAGCTGGGGACCTGGCCATTGGGGCAGCCCTGTTTCTG
gorilla         CGAGGCCAGGAGCTCACCC-TCCAGCTGGGGACCTGGCCAGTGGGGCAGCCCTGTTCCTG
orang           CGAGGCCAGGAGCTCGCCC-TCCAGCTGGAGACCTGGCCATTGGGGCAGCCCTGTCCCTG
                *************** *** ********* ********** **************  ***

human           AAGCTCTGAGCTCACCCCTTCCCCATGACCACATCAGCCCCCCTCCACCCAGAGATGTCA
chimp           AAGCTCTGAGCTCACCCCTTCCCCATGACCACATCAGCCCCCTTCCACCCAAAGATGTCA
gorilla         AAGCTCTGAGCTCACCCCTTCCCCATGACCACATCAGCCCCCCTCCACCCAGAGATGTCA
orang           AAGCTCTGAGCTCACCCCTTCCCCATGACCACATCAGCCCCCCTCCACCCAGAGATGTCA
                ****************************************** ******** ********

human           CAGCCCCCAGCTAGCCCCGCCTCCAGAGTGGGGGCCAAGGCTGGGCAGGCGGGTGGACGG
chimp           CAGCCCCCAGCTAGCCCCGCCTCCAGAGTGGGGGCCAAGGCTGGGCAGGCGGGTGGACGG
gorilla         CAGCCCCCAGCTAGCCCCGCCTCCAGAGTGGGGGCCAAGGCTGGGCAGGCGGGTGGACGG
orang           CAGCCCCCAGCTAGCCCCGCCTCCAGAGTGGGGGCCAAGGCTGGGCAGGCGGGTGGACGG
                ************************************************************
                             IGF2 Exon 1 (5´ UTR)
human           CCGGACACTGGCCCCGGAAGAGGAGGGAGGCGGTGGCTGGGATCGGCAGCAGCCGTCCAT
chimp           CCGGACACTGGCCCCGGAAGAGGAGGGAGGCGGTGGCTGGGATCTGCAGCAGCCGTCCAT
gorilla         CCGGACACTGGCCCCGGAAGAGGAGGGAGGCGGTGGCTGGGATCGGCAGCAGCCGTCCAT
orang           CCGGACACTGGCCCCGGAAGAGGAGGGAGGCGGTGGCTGGGATCGGCAGCAGCCGTCCAT
                ******************************************** ***************

human           GGGAACACCCAGCCGGCCCCACTCGCACGGGTAGAGACAGGGGCGCCCTGCTGGAGCTGA
chimp           GGGAACACCCAGCCGGCCCCACTCGCACGGGTAGAGACAGGGGCGCCCTGCTGGAGCTGA
gorilla         GGGAACACCCAGCCGGCCCTACTCGCACGGGTAGAGACAGGGGCGCCCTGCTGGAGCTGA
orang           GGGAACACCCAGCCGGCCCCACTCGCACGGGTAGAGACAGGGGCGCCCTGCTGGAGCTGA
                ******************* ****************************************
                      IGF2 Intron 1
human           GGTATGTGAGCTCGCGCGGGGCTGGGCCAAAGCGGGGCCCGGTGGGCCGGCTGGGAGGCT
chimp           GGTATGTGAGCTCGCGCGGGGCTGGGCCAAAGCGGGGCCCGGTGGGCCGGCTGGGAGGCT
gorilla         GGTATGTGAGCTCGCGCGGGGCTGGGCCAAAGTGGGGCCCGGTGGGCCGGCTGGGAGGCT
orang           GGTATGTGAGCTCGCGCGGGGCTGGGCCAAAGTGGGGCCCGGTGGGCCGGCTGGGAGGCT
                ******************************** ***************************

human           GCCCACCAGTCAGCCATCGGCCAAGCTGTTGCCCTGGCTGACCCTGATGGCCAACAAGGC
chimp           GCCCACCAGTCAGCCATCGGCCAAGCTGTTGCCCTGGCTGACCCTGATGGCCAACAAGGC
gorilla         GCCCACCAGTCAGCCATCGGCCAAGCTGTTGCCCTGGCTGACCCTGATGGCCAACAAGGC
orang           GCCCACCAGTCAGCCATCAGCCAAGCTGTTGCCCTGGCTGACCCTGATGGCCAACAAGGC
                ****************** *****************************************
                                      INS-51
human           CGTAGGGAGTGATGGGCAGAGGCCCSTTCTGGGAGGGGAGGGTCAGTGCTCTGTGGGGGA
chimp           CGCAGGGAGTGATGGGCAGAGGCCCGTTCTGGGAGGGGAGGGTCAGTGCTCTGTGGGGGA
gorilla         CGTAGGGAGTGATGGGCAGAGGCCCGTTCTGGGAGGGGAGGGTCAGTGCTCTGTGGGGGA
orang           CATAGGGAGTGATGGGCAGAGGCCCCTTCTGGGAGGGGAGGGTCAGTGCTCTGTGGGGGA
                *  ********************** **********************************
                 INS-52
human           CCGTRTGTTGGAGTGGAGGGCAGCAGGAGGAGCCCTTTGGTGTCCAGGGACTCCTGGAGC
chimp           CCATGTGTTGGAGTGGAGGGCAGCAGGAGGAGCCCTTTGGTGTCCAGGGACTCCTGGAGC
gorilla         CCGTGTGTTGGAGTGGAGGGCAGCAGGAGGAGCCCTTTGGTGTCCAGGGACTCCTGGAGC
orang           CCGTGTGTTGGAGAGGTGGGCAGCAGGAGGAGCCCTTTGGTGTCCGGGGACTCCTGGAGC
                ** * ******** ** **************************** **************
                                                                  INS-53
human           TGCCCCAGCCTTCCAGGACTTGCAGGGCAGCTGGCACTGGCTGGTGCTGGGGGMTGAGGA
chimp           TGCCCCAGCCTTCCAGGACTTGCAGGGCAGCTGGCACTGGCTGGTGCTGGGGGCTGAGGA
gorilla         TGCCCCAGCCTTCCAGGACTTGCAGGGCAGCTGGCACTGGCTGGTGCTGGGGGCTGAGGA
orang           TGCCCTAGCCTTCCAGGACTTGCAGGGCAGCTGGCACTGGCTGGTGCTGGGGGCTGAGGA
                ***** *********************************************** ******
                    INS-54
human           GTGTCTTYTGAGGGGCCAAATTTTCTGTGACTTCTGTCCTGGGGGACCTCTGACCTGAGG
chimp           GTGTCTTTTGAGGGGCCAAATTTTCTGTGACTTCTGTCCTGGGGGACCTCTGACCTGAGG
gorilla         GTGTCTTTTGAGGGGCCAAATTTTCTGTGACTTCTGTCCTGGGGGACCTCTGACCTGAGG
orang           GTGTCTTTTGAGGGGCCAAATTTTCTGTGACTTCTGTCGTGGGTGACCTCTGACCTGAGG
                ******* ****************************** **** ****************
                                INS-73
human           CCTCAGGAGAGGGCAAGGCYGCCCACCCAAAAGAGATGCAGCCATGGTTCGCGGTGCCCT
chimp           CCTCAGGAGAGGGCAAGGCCGCCCACCCAAAAGAGATGCAGCCATGGTTCGCGGTGCCCT
gorilla         CCTCAGGAGAGGGCAAGGCTGCCCACCCA--AGAGACGCAGCCATGGTTCGCGGTGCCCT
orang           CCTCAGGAGAGGGCAAGGCTGCTCACCCAAAAGAGACGCAGCCATGGTTCGCGGTGCCCT
                ******************* ** ******  ***** ***********************
                         INS-56
human           CGGCTGCCCTGGRCCAGAGCTGGGGCTAGCTTTCACCTTGTTGAGACCCAGGACTCTGTC
chimp           CAGCTGCCCTGGGCCAGAGCTGGGGCTAGCTTTCACCTTGTTGAGACCCAGGACTCTGTC
gorilla         CGGCTGCCCTGGGCCAGAGCTGGGGCTAGCTTTCACCTTGTTGAGACCCAGGACTCTGTC
orang           CGGCTGCCCTGGGCCAGAGCTAGGGCCAGCTTTCGCCTTGTTGAGACCCAGGACTCTGTC
                * ********** ******** **** ******* *************************
                                   INS-74
human           CCCCAAGCCTGTCTTCGCCAGCRCCTTGACCCCACCCCTCATATACTGTGTCCTGGAAAA
chimp           CCCCAAGCCTGTCTTCGCCAGCGCCTTGACCCCACCCCCCACACACTGTGTCCTGGAAAA
gorilla         CCCCAAGCCTGTCTTCGCCAGCGCCTTGACCCCGCCCCC-ACACACTGTGTCCTGGAAAA
orang           CCCCAAGCCTGCCTTCACCAGCGCCCTGACCCCACCCCCCATACACTGTGTCCTGGAAAA
                *********** **** ***** ** ******* ****  * * ****************
                              INS-57
human           CGTGGACACGGGAGACCRCAGCCAGGGCGAGGTATCGCCCCTCCATCCCCCCAGGCCCAA
chimp           GGTGGACACAGGAGACCACAGCCAGGGCGAGGTATCGCCCCTCCATCCCCCCAGGCCCAA
gorilla         GGTGGACACGGGAGACCACAGCCAGGGTGAGGTAYCGCGCCTCCATCCCCCCAGGCCCAA
orang           GGTGGACACGGGAGACCACAGCCAGGGCGAGGTATCGCCCCTCCATCCCCCCAGGTCCAA
                 ******** ******* ********* ****** *** **************** ****
                   INS-60
human           TGAGAARCAGTTGGCCAAGGTGATCCAGGTGGCAGAGGCAGCATCAGACCCAGTCTCCTG
chimp           TGAGAAGCAGTTGGCCAAGGTGATCCAGGTGGCAGAGGCAGCATCAGACCCAGTCTTCTG
gorilla         TGAGAAGCAGTTGGCCTAGGTGATCCAGGTGGCAGAGGCAGCATCAGACCCAGTCTCCTG
orang           TGAGAAGCAGCTGGCCAAGGTGACCCAGGTGGCAGAGGCAACATCAGACCCAGTCTTCTT
                ****** *** ***** ****** **************** *************** ** 

human           TCAGGCACCACCTTGGGTGCCGGTCCCCAGATGCCCTGGCGGGGAGTGTGCATGCTCCCG
chimp           TCAGGCACCACCTTGGGTGCCGGTCCCCAGATGCCCTGGCGGGGAGTGTGGATGCTCCCG
gorilla         TCAGGCACCACCTTGGGTGCCGGTCCCCAGATGCCCTGGCGGGGAGTGTGGATGCTCCCG
orang           TCGGGCACCACCTTGGGTGCCGGTCCCCAGGTGCCCTGGCGGGGATTGTGGATGCTTCCG
                ** *************************** ************** **** ***** ***

human           GAGCCCCCAGGTCACCCCATGTGAGCCAGGCCCACAGAGCTTGGCTCTGCAATGCCTGCT
chimp           GAGCCCCCAGGTCACCCCATGTGAGCCAGGCCCACAGAGCTTGGCTCTGCAATGCCTGCT
gorilla         GAGCCCCCAGGTCACCCCATGTGAGCCAGGCCCACAGAACTTGGCTCTGCAATGCCTGCT
orang           GAGCCCCCAGGTCACCCCATGTGAGCCAGGCCCACAGAGCTTGGCTCTGCAACGCCTGCT
                ************************************** ************* *******
                                                            INS-63
human           GGGCTGCTGCCCATGCTCCACCCCTTCTGGGAAGCTAAAAGACAGCCYTTCAGTGTCCAG
chimp           GGGCCGCTGCCTATGCTCCACCCCTTCTGGGAAGCTAAAAGACAGCCCTTCAGTGTCCAG
gorilla         GGGCCGCTGCCTATGCTCCACC--TTCTGGGAAGCTAAAAGACAGCCCTTCAGTGTCCAG
orang           GGGCTGCTGCCTATGCTCCACCCCTTCTGGGAAGCTAAAAGACAGCCCTTCAGTGTCCAG
                **** ****** **********  *********************** ************
                                    INS-64           INS-66
                                       INS-65         INS-67
human           AGACCTGCCTGGCCTTGGAGCCTSGGYTTCACATGCCCACYRGGCTGGCAGGGGCACTCA
chimp           AGACCTGCCTGGCCTTGGAGCCTGGGTTTCACATGCCCACCAGGCTGGCAGGGGCACTCA
gorilla         AGACCTGCCTGGCCTTGGAGCCTGGGTTTCACATGCTCACCGGGCTGGCAGGGGCACTCA
orang           AGACCTACCTGGCCTTGGAGCCTGGGCTTCACATGCCCACTGGGCTGGCAGGGACA????
                ****** **************** ** ********* ***  *********** ******
                            INS-68
human           GCTGCCTCCAGCCCCRGCGGTCACCCTGGCATTGGGTCCATCTAACTGCTCCCCAGTCAC
chimp           GCTGCCTCCAGCCCCGGCGGTCACCCTGGCA?????????????????????????????
gorilla         GCT?????????????????????????????????????????????????????????
orang           ????????????????????????????????????????????????????????????
                ***                                                         

human           AAG
chimp           ???
gorilla         ???
orang           ???