Mutation events at the insulin
minisatellite
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Genotypes of donors
Somatic mutants
- Class I germline
deletions
-
Class III germline
deletions
Simple germline
duplications
Complex germline duplications
Inter-allelic germline
mutants
|
Genotypes of donors
Donor 1
Progenitor ID40.2 CBoBoFAFAAACACAAAAFACAAAABAAABABCAAAFBBB
Progenitor IIIA152.2 CBoBACAACAoAoACAACABAAAABABAAEAABBAABAAAAAoACABAEAACAoACAAABAAACAoACACAAAABAABAAAoAAAAoACAACAAACAAABACEAABCEAAABCEAAAABCAAAABAAAEAAABAABAAFAAAAFAABoHBBB
Donor 2
Progenitor ID42.4 CBoBoFAFAAACACAAAAFACAAAABAAAABABABCAAAFBB
Progenitor IIIB145.1 CBoBoBAoFAEAAACEAAACAFAAAAFACEAAACACAFACECCAFAoBoBAoFACEAAACAAAFACAAACACAAAAFCAAAFACEoEAFAEAFACAAFACEAEAABAAAAAFAAAFAAAABCAAFAAAAAFAABoACAoAAAAAB
Donor 3
Progenitor ID44.1 CBoBoFAFAAACACAAAAAFACAAAABAAAABABABCAAAFBBB
Progenitor ID44.1 CBoBoFAFAAACACAAAAAFACAAAABAAAABABABCAAAFBBB
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Somatic (blood DNA) mutants
Donor 1
Deletion mutations from class I progenitor
Progenitor CBoBoFAFAAACACAAAAFACAAAABAAABABCAAAFBBB
B1-38.1 CBo--FAFAAACACAAAAFACAAAABAAABABCAAAFBBB
B1-38.2* CBoBoF--AAACACAAAAFACAAAABAAABABCAAAFBBB
B1-38.3* CBoBoF--AAACACAAAAFACAAAABAAABABCAAAFBBB
B1-38.4* CBoBoF--AAACACAAAAFACAAAABAAABABCAAAFBBB
B1-33.1 CBoBoFAFAAACAC-------AAAABAAABABCAAAFBBB
B1-35.1 CBoBoFAFAAACACAA-----AAAABAAABABCAAAFBBB
B1-38.5 CBoBoFAFAAACACAAA--ACAAAABAAABABCAAAFBBB
B1-35.2 CBoBoFAFAAACACAAAAF-----ABAAABABCAAAFBBB
B1-33.2 CBoBoFAFAAACACAAAAFACAA-------ABCAAAFBBB
B1-34.1 CBoBoFAFAAACACAAAAFACAAAABAAABA------BBB
B1-32.1 CBoBoFAFAAACACAAAAFACAAAABAAABAB--------
B1-38.6 CBoBoFAFAAACACAAAAFACAAAABAAABABC--AFBBB
B1-37.1 CBoBoFAFAAACACAAAAFACAAAABAAABABCAAAF---
Simple duplications of class I progenitor
B1-44.1 CBoBoFAFAAACACAAAAFACAAAABAAAB
AAABABCAAAFBBB
B1-42.1 CBoBoFAFAAACACAAAAFACAAAABAAABABCAAAFBB
BBB
Complex duplications of class I progenitor
B1-75.1 CBoBoFAFAAACACAAAAFACAAAABAAABABCAA
CAA---------BAAABABCAA
CAAAAFACAAAABAAABABCAAAFBBB
Deletion mutations from class III progenitor
Progenitor CBoBACAACAoAoACAACABAAAABABAAEAABBAABAAAAAoACABAEAACAoACAAABAAACAoACACAAAABAABAAAoAAAAoACAACAAACAAABACEAABCEAAABCEAAAABCAAAABAAAEAAABAABAADAAAADAABoHBBB
B1-67.1 CBoBACAACAoAoACAACABAAAABABAAEAABBAABAAAAAoACABA-------------------------------------------------------------------------------------AABAADAAAADAABoHBBB
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Germline (sperm DNA) mutants
Class I deletion mutations
Donor 1
Progenitor CBoBoFAFAAACACAAAAFACAAAABAAABABCAAAFBBB
S1-10.1 C------------------------------BCAAAFBBB
S1-24.1 CB----------------FACAAAABAAABABCAAAFBBB
S1-38.1 CBoB--AFAAACACAAAAFACAAAABAAABABCAAAFBBB
S1-37.1* | CBoBoF---AACACAAAAFACAAAABAAABABCAAAFBBB
S1-37.2* | CBoBoF---AACACAAAAFACAAAABAAABABCAAAFBBB
S1-38.2* | CBoBoFAFAAAC--AAAAFACAAAABAAABABCAAAFBBB
S1-38.3* | CBoBoFAFAAAC--AAAAFACAAAABAAABABCAAAFBBB
S1-38.4* | CBoBoFAFAAAC--AAAAFACAAAABAAABABCAAAFBBB
S1-38.5* | CBoBoFAFAAAC--AAAAFACAAAABAAABABCAAAFBBB
S1-38.6* | CBoBoFAFAAAC--AAAAFAFAAAABAAABABCAAAFBBB
S1-38.7* | CBoBoFAFAAAC--AAAAFAFAAAABAAABABCAAAFBBB
S1-38.8* | CBoBoFAFAAAC--AAAAFAFAAAABAAABABCAAAFBBB
S1-38.9 CBoBoFAFAAAC--AAAAFAAAAAABAAABABCAAAFBBB
S1-38.10 CBoBoFAFAAACACAAAA--CAAAABAAABABCAAAFBBB
S1-34.1 CBoBoFAFAAACACAAAAFACA------oBABCAAAFBBB
S1-36.1 CBoBoFAFAAACACAAAAFACAAA----ABABCAAAFBBB
S1-38.11 CBoBoFAFAAACACAAAAFACAAAA--AABABCAAAFBBB
S1-33.1 CBoBoFAFAAACACAAAAFACAAAABA-------AAFBBB
S1-34.2 CBoBoFAFAAACACAAAAFACAAAABAA------AAFBBB
S1-35.1 CBoBoFAFAAACACAAAAFACAAAABAAA-----AAFBBB
S1-32.1* CBoBoFAFAAACACAAAAFACAAAABAAABA--------B
S1-32.2* CBoBoFAFAAACACAAAAFACAAAABAAABA--------B
Donor 2
Progenitor CBoBoFAFAAACACAAAAFACAAAABAAAABABABCAAAFBB
S2-40.1 CBoBoF--AAACACAAAAFACAAAABAAAABABABCAAAFBB
S2-39.2 CBoBoFAFAA---CAAAAFACAAAABAAAABABABCAAAFBB
S2-40.2* CBoBoFAFAAAC--AAAAFACAAAABAAAABABABCAAAFBB
S2-40.3* CBoBoFAFAAAC--AAAAFACAAAABAAAABABABCAAAFBB
S2-40.4 CBoBoFAFAAACACAA--FACAAAABAAAABABABCAAAFBB
S2-40.5* CBoBoFAFAAAC--AAAAFAFAAAABAAAABABABCAAAFBB
S2-40.6* CBoBoFAFAAAC--AAAAFAFAAAABAAAABABABCAAAFBB
S2-40.7 CBoBoFAFAAACAC--AAFAFAAAABAAAABABABCAAAFBB
S2-40.8 CBoBoFAFAAACACAAAA--CAAAABAAAABABABCAAAFBB
S2-35.1* | CBoBoFAFAAACACAAAA-------BAAAABABABCAAAFBB
S2-35.2* | CBoBoFAFAAACACAAAA-------BAAAABABABCAAAFBB
S2-37.1* | CBoBoFAFAAACACAAAAFACAAAA-----BABABCAAAFBB
S2-37.2* | CBoBoFAFAAACACAAAAFACAAAA-----BABABCAAAFBB
S2-37.3* | CBoBoFAFAAACACAAAAFACAAAA-----BABABCAAAFBB
S2-33.1 CBoBoFAFAAACACAAAAFACAAAA---------BCAAAFBB
S2-40.9 CBoBoFAFAAACACAAAAFACAAAABAA--BABABCAAAFBB
S2-40.10* CBoBoFAFAAACACAAAAFACAAAABAAAA--BABCAAAFBB
S2-40.11* CBoBoFAFAAACACAAAAFACAAAABAAAA--BABCAAAFBB
Donor 3
Progenitor CBoBoFAFAAACACAAAAAFACAAAABAAAABABABCAAAFBBB
S3-36.1 CBoBoFAFAAA--------FACAAAABAAAABABABCAAAFBBB
S3-24.1 CBoBoFAFAAA--------------------BABABCAAAFBBB
S3-42.1* CBoBoFAFAAAC--AAAAAFACAAAABAAAABABABCAAAFBBB
S3-42.2* CBoBoFAFAAAC--AAAAAFACAAAABAAAABABABCAAAFBBB
S3-42.3* CBoBoFAFAAAC--AAAAAFACAAAABAAAABABABCAAAFBBB
S3-42.4* CBoBoFAFAAAC--AAAAAFACAAAABAAAABABABCAAAFBBB
S3-42.5* CBoBoFAFAAAC--AAAAAFACAAAABAAAABABABCAAAFBBB
S3-42.6* CBoBoFAFAAAC--AAAAAFACAAAABAAAABABABCAAAFBBB
S3-30.1 CBoBoFAFAAACA--------------AAAABABABCAAAFBBB
S3-41.1 CBoBoFAFAAACA?A---AFACAAAABAAAABABABCAAAFBBB
S3-42.7 CBoBoFAFAAACACAA--AFACAAAABAAAABABABCAAAFBBB
S3-23.1 CBoBoFAFAAACACAAAAAF---------------------BBB
S3-36.2 CBoBoFAFAAACACAAAAAFACAAA--------BABCAAAFBBB
S3-35.1 CBoBoFAFAAACACAAAAAFACAAAA---------BCAAAFBBB
S3-32.1 CBoBoFAFAAACACAAAAAFACAAAA------------AAFBBB
S3-42.8 CBoBoFAFAAACACAAAAAFACAAAABA--ABABABCAAAFBBB
S3-35.2 CBoBoFAFAAACACAAAAAFACAAAABAAAAB---------BBB
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Class III deletion mutations
Donor 1
Progenitor CBoBACAACAoAoACAACABAAAABABAAEAABBAABAAAAAoACABAEAACAoACAAABAAACAoACACAAAABAABAAAoAAAAoACAACAAACAAABACEAABCEAAABCEAAAABCAAAABAAAEAAABAABAAFAAAAFAABoHBBB
S1-74.1 CBoBACAACAoAoACAACABAAAABABAAEAABBAA-----------------------------------------------------------------------------AAAAABCAAAABAAAEAAABAABAAFAAAAFAABoHBBB
S1-64.1 CBoBACAACAoAoACAACABAAAABABAAEAABBAABAAAA---------------------------------------------------------------------------------------EAAABAABCAFAAAAFAABoHBBB
S1-15.1 CBoBACAACAoAo-----------------------------------------------------------------------------------------------------------------------------------------BB
Donor 2
Progenitor CBoBoBAoFAEAAACEAAACAFAAAAFACEAAACACAFACECCAFAoBoBAoFACEAAACAAAFACAAACACAAAAFCAAAFACEoEAFAEAFACAAFACEAEAABAAAAAFAAAFAAAABCAAFAAAAAFAABoACAoAAAAAB
S2-70.1 CBoBoBAoFAEAAACEAAACAFAAAAFACEAAACACAFACEC---------------------------------------------------------------------------AAABCAAFAAAAAFAABoACAoAAAAAB
S2-58.1 CBoBoBAoFAEAAACEAAACAFAAAAFA---------------------------------------------------------------------------------------AAAAABCAAFAAAAAFAABoACAoAAAAAB
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Simple duplications
Donor 1
Progenitor CBoBoFAFAAACACAAAAFACAAAABAAABABCAAAFBBB
S1-44.1 CBoBoFAFAAACACAAAAFACAAAA
AAAABAAABABCAAAFBBB
Progenitor CBoBoFAFAAACACAAAAFACAAAABAAABABCAAAFBBB
S1-43.1 CBoBoFAFAAACACAAAAFACAAAABAAA
AAABABCAAAFBBB
Progenitor CBoBoFAFAAACACAAAAFACAAAABAAABABCAAAFBBB
S1-42.1 CBoBoFAFAAACAC
ACAAAAFACAAAABAAABABCAAAFBBB
Donor 2
Progenitor CBoBoFAFAAACACAAAAFACAAAABAAAABABABCAAAFBB
S2-54.1* CBoBoFAFAAACACAAAAFACAA
CACAAAAFACAAAABAAAABABABCAAAFBB
Progenitor CBoBoFAFAAACACAAAAFACAAAABAAAABABABCAAAFBB
S2-54.2* CBoBoFAFAAACACAAAAFACAA
CACAAAAFACAAAABAAAABABABCAAAFBB
Progenitor CBoBoFAFAAACACAAAAFACAAAABAAAABABABCAAAFBB
S2-49.1 CBoBoFAFAAACACAAAAFACAAAABAAAABAB
AAAABABABCAAAFBB
Progenitor CBoBoFAFAAACACAAAAFACAAAABAAAABABABCAAAFBB
S2-48.1 CBoBoFAFAAACACAAAAFACAAAABAAAA
ABAAAABABABCAAAFBB
Progenitor CBoBoFAFAAACACAAAAFACAAAABAAAABABABCAAAFBB
S2-47.1 CBoBoFAFAAACACAAAAFACAAAABAAAABABABCAAAF
CAAAFBB
Progenitor CBoBoFAFAAACACAAAAFACAAAABAAAABABABCAAAFBB
S2-46.1 CBoBoFAFAAACACAAAAFACAAAABAAAABABAB
ABABCAAAFBB
Progenitor CBoBoFAFAAACACAAAAFACAAAABAAAABABABCAAAFBB
S2-45.1 CBoBoFAFAAACACAAAAFACAAAAB
AABAAAABABABCAAAFBB
Progenitor CBoBoFAFAAACACAAAAFACAAAABAAAABABABCAAAFBB
S2-45.2 CBoBoFAFAAACACAAAAFACAAAABAAAABABA
ABABCAAAFBB
Donor 3
Progenitor CBoBoFAFAAACACAAAAAFACAAAABAAAABABABCAAAFBBB
S3-65.1 CBoBoFAFAAACACAAAAAFACAAAA
FAFAAACACAAAAAFACAAAABAAAABABABCAAAFBBB
Progenitor CBoBoFAFAAACACAAAAAFACAAAABAAAABABABCAAAFBBB
S3-65.2 CBoBoFAFAAACACAAAAAFAC
BoBoFAFAAACACAAAAAFACAAAABAAAABABABCAAAFBBB
Progenitor CBoBoFAFAAACACAAAAAFACAAAABAAAABABABCAAAFBBB
S3-62.1 CBoBoFAFAAACACAAAAAFACAAAABAAAA
CAAAAAFACAAAABAAAABABABCAAAFBBB
Progenitor CBoBoFAFAAACACAAAAAFACAAAABAAAABABABCAAAFBBB
S3-59.1 CBoBoFAFAAACACAAAAAFACAAAABAAAABABAB
CAAAABAAAABABABCAAAFBBB
Progenitor CBoBoFAFAAACACAAAAAFACAAAABAAAABABABCAAAFBBB
S3-54.1* CBoBoFAFAAACACAAAAAFACAAAABAAAAB
AAAAB
AAAABABABCAAAFBBB
Progenitor CBoBoFAFAAACACAAAAAFACAAAABAAAABABABCAAAFBBB
S3-54.2* CBoBoFAFAAACACAAAAAFACAAAABAAAAB
AAAAB
AAAABABABCAAAFBBB
Progenitor CBoBoFAFAAACACAAAAAFACAAAABAAAABABABCAAAFBBB
S3-54.3 CBoBoFAFAAACACAAAAAFACAAAABAA
FACAAAABAAAABABABCAAAFBBB
Progenitor CBoBoFAFAAACACAAAAAFACAAAABAAAABABABCAAAFBBB
S3-53.1 CBoBoFAFAAACACAAAAAFACAAAA
AAFACAAAABAAAABABABCAAAFBBB
Progenitor CBoBoFAFAAACACAAAAAFACAAAABAAAABABABCAAAFBBB
S3-52.1 CBoBoFAFAAACACAAAAAFACAAAABAAAABABABCAA
BABABCAAAFBBB
Progenitor CBoBoFAFAAACACAAAAAFACAAAABAAAABABABCAAAFBBB
S3-51.1* CBoBoFAFAAACACAAAAAFACAAAABAAAABA
BAAAABABABCAAAFBBB
Progenitor CBoBoFAFAAACACAAAAAFACAAAABAAAABABABCAAAFBBB
S3-51.2* CBoBoFAFAAACACAAAAAFACAAAABAAAABA
BAAAABABABCAAAFBBB
Progenitor CBoBoFAFAAACACAAAAAFACAAAABAAAABABABCAAAFBBB
S3-51.3* CBoBoFAFAAACACAAAAAFACAAAABAAAABA
BAAAABABABCAAAFBBB
Progenitor CBoBoFAFAAACACAAAAAFACAAAABAAAABABABCAAAFBBB
S3-51.4 CBoBoFAFAAACACAAAAAFACAAAAB
ACAAAABAAAABABABCAAAFBBB
Progenitor CBoBoFAFAAACACAAAAAFACAAAABAAAABABABCAAAFBBB
S3-50.1 CBoBoFAFAAACAC
AAACACAAAAAFACAAAABAAAABABABCAAAFBBB
Progenitor CBoBoFAFAAACACAAAAAFACAAAABAAAABABABCAAAFBBB
S3-49.1 CBoBoFAFAAACACAAAAAFACAAAABAAAAB
AAAABABABCAAAFBBB
Progenitor CBoBoFAFAAACACAAAAAFACAAAABAAAABABABCAAAFBBB
S3-49.2 CBoBoFAFAAACACAAAAAFACAAAABAAAABAB
AABABABCAAAFBBB
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Complex intra-allelic duplications
Donor 1
Progenitor CBoBoFAFAAACACAAAAFACAAAABAAABABCAAAFBBB
S1-68.1 CBoBoFAFAAACACAAAAFACAAAABAAABABCAA
FAAACACAAAACACAAAABAAABABCAAAFBBB
Progenitor CBoBoFAFAAACACAAAAFACAAAABAAABABCAAAFBBB
S1-67.1 CBoBoFAFAAACACAAAAFACAAAABAAA--BCAAAFB
AB---BABCAAAF
BAAABCAAAFBABCAAAFBBB
Progenitor CBoBoFAFAAACACAAAAFACAAAABAAABABCAAAFBBB
S1-60.1 CBoBoFAFAAACACAAAA
AAAAAFACAAAA
AAAAAAAAFACAAAABAAABABCAAAFBBB
Progenitor CBoBoFAFAAACACAAAAFACAAAABAAABABCAAAFBBB
S1-52.1 CBoBoFAFAAACACAAAAFACAAAABA--BAB
ABA--BAB-AA
AAABABCAAAFBBB
Progenitor CBoBoFAFAAACACAAAAFACAAAABAAABABCAAAFBBB
S1-47.1 CBoBoFAFAAACACAAAAFACAAAA---ABAB
AAABAAABABCAAAFBBB
Progenitor CBoBoFAFAAACACAAAAFACAAAABAAABABCAAAFBBB
S1-44.2 CBoBoFAFAAACACAAAAFACAAAABAAABABCAAAFBB
BCA----BB
Donor 2
Progenitor CBoBoFAFAAACACAAAAFACAAAABAAAABABA--BCAAAFBB
S2-80.1 CBoBoFAFAAACACAAAAFACAAAABAAAABABABABC
-AAAABABABABC
AAAAFACAAAABAAAABABABABCAAAFBB
Progenitor CBoBoFAFAAACACAAAAFACAAAABAAAABABABCAAAFBB
S2-57.1 CBoBoFAFAAACACAAAAFAACAAF
-AAFAAFAA
CACAAAABAAAABABABCAAAFBB
Progenitor CBoBoFAFAAACACAAAAFACAAAABAAAABABABCAAAFBB
S2-57.2 CBoBoFAFAAACACAAAAFACAAAA
AAFAA-C-CAAAAF---AAABAAAABABABCAAAFBB
Progenitor CBoBoFAFAAACACAAAAFACAAAABAAAABABABCAAAFBB
S2-54.3 CBoBoFAFAAACACAAAAFACAAA
F-----CAAAAFAFAAAABAAAABABABCAAAFBB
Progenitor CBoBoFAFAAACACAAAAFACAAAABAAAABABABCAAAFBB
S2-54.4 CBoBoFAFAAACACAAAAFACAAAABAAAABABA
AAAAAAFACAAAA----------CAAAFBB
Progenitor CBoBoFAFAAACACAAAAFACAAAABAAAABABABCAAAFBB
S2-49.2 CBoBoFAFAAACACAAAAFACAAAABAAAABABAB
AAAABA--BCAAAFBB
Progenitor CBoBoFAFAAACACAAAAFACAAAABAAAABABABCAAAFBB
S2-49.3 CBoBoFAFAAACACAAAAFAC-AAABAAA-B
AAABAAAABABABCAAAFBB
Progenitor CBoBoFAFAAACACAAAAFACAAAABAAAABABABCAAAFBB
S2-48.2 CBoBoFAFAAACAC
CA-AAAA
C-AAAFACAAAABAAAABABABCAAAFBB
Progenitor CBoBoFAFAAACACAAAAFACAAAABAAAABABABCAAAFBB
S2-48.3 CBoBoFAFAAACA-AAAA
CACCAAAFACAAAABAAAABABABCAAAFBB
Progenitor CBoBoFAFAAACACAAAAFACAAAABAAAABABABCAAAFBB
S2-48.4 CBoBoFAFAAACACAAAAFACAAAABAA
CAAAABAA--BABABCAAAFBB
Donor 3
Progenitor CBoBoFAFAAACACAAAAAFACAAAABAAAABABABCAAAFBBB
S3-109.1 CBoBoFAFAAACACAAAAAFACAAAABAAAABABABCAAAFB
AAoBoFAFAAACACAAAAAFACAAAABAAAABABABCAAAFB
A-AAAABAAAABABABCAAAFBBB
Progenitor CBoBoFAFAAACACAAAAAFACAAAABAAAABABABCAAAFBBB
S3-100.1 CBoBoFAFAAACACAAAAAFACAAAABAAAA
CA--------CAAAABAAAA
CA--------CAAAABAAAA
CA--------CAAAABAAAA
CACAAAAAFACAAAABAAAABABABCAAAFBBB
Progenitor CBoBoFAFAAACACAAAAAFACAAAABAAAABABABCAAAFBBB
S3-93.1 CBoBoFAFAAACACAAAAA
AAAFACAAAABAAAA
CAAAA
CAAAAAAAC
AF
AAAAFAAAA
CAAAAAAAA
FACAAAABAAAABABABCAAAFBBB
Progenitor CBoBoFAFAAACACAAAAAFACAAAABAAAABABABCAAAFBBB
S3-90.1 CBoBoFAFAAACACAAAAAFACAAAABAAAABAB
AAAABAAA-B
CAAAABAAAABABAB
AABAB
AAAB
CAAAABAAAABABABCAAAFBBB
Progenitor CBoBoFAFAAACACAAAAAFACAAAABAAAABABABCAAAFBBB
S3-90.2 CBoBoFAFAAACACAAAAAFACAAAABAAAABABAB
-AAAABABABC
AAFACAAA
AAFACAAAABAAAABABAB
AAAABABABCAAAFBBB
Progenitor CBoBoFAFAAACACAAAAAFACAAAABAAAABABABCAAAFBBB
S3-89.1 CBoBoFAFAAACACAAAAAFACAAAABAAAABABABBAAAFAABA
AAF
AAFAABA
oBoFAFAAA--------FACAAAABAAAABABABCAAAFBBB
Progenitor CBoBoFAFAAACACAAAAAFACAAAABAAAABABABCAAAFBBB
S3-88.1 CBoBoFAFAAACACAAAAAFACAAAABAAAAAABAA
CAAAA-AAAA-----CAA
CAAAABAAAA
AABAAA-BA
AAAABAAAABABABCAAAFBBB
Progenitor CBoBoFAFAAACACAAAAAFACAAAABAAAABABABCAAAFBBB
S3-86.1 CBoBoFAFAAACACAAAAAFACAAAAB
AAAFACAAAAB
AAAFACAAAAB-----ABABCAAAF
AAAFACAAAABAAAABABABCAAAFBBB
Progenitor CBoBoFAFAAACACAAAAAFACAAAABAAAABABABCAAAFBBB
S3-86.2 CBoBoFAFAAACACAAAAAFACAAAABAAAABAB
BAAAAA
AAAAAFA
ACAAA--F
CACAAAAAFACAAAABAAAABABABCAAAFBBB
Progenitor CBoBoFAFAAACACAAAAAFACAAAABAAAABABABCAAAFBBB
S3-83.1 CBoBoFAFAAACACAAAAAFACAAAABAAAABABA
FACAA--BAAAA
FACAAAA-AAAABAB
ACAAAABAAAABABABCAAAFBBB
Progenitor CBoBoFAFAAACACAAAAAFACAAAABAAAABABABCAAAFBBB
S3-78.1 CBoBoFAFAAACACAAAAAFACAAAABAAAABABABCAA
BAAAA
CAAAAAB
ACAA--B
AAAABAAAABABABCAAAFBBB
Progenitor CBoBoFAFAAACACAAAAAFACAAAABAAAABABABCAAAFBBB
S3-77.1 CBoBoFAFAAACACAAAAAFACAAAABAAAABABA
F----AABA
AAACACAAAAAFACAAAABAAAABABABCAAAFBBB
Progenitor CBoBoFAFAAACACAAAAAFACAAAABAAAABABABCAAAFBBB
S3-73.1 CBoBoFAFAAACACAAAAAFACAAAABAAAABABABCAAA
BABABCAAA
BA---BABABCAAA
BABABCAAAFBBB
Progenitor CBoBoFAFAAACACAAAAAFACAAAABAAAABABABCAAAFBBB
S3-72.1 CBoBoFAFA----CAAA
CACAAA
CAACAA
FAAACAACAA
FAAACACAAAAAFACAAAABAAAABABABCAAAFBBB
Progenitor CBoBoFAFAAACACAAAAAFACAAAABAAAABABA--BCAAAFBBB
S3-69.1 CBoBoFAFAAACACAAAAAFACAAAABAAAABABABABCAAA
FACAAAABAAAABABABABCAAAFBBB
Progenitor CBoBoFAFAAACACAAAAAFACAAAABAAAABABABCAAAFBBB
S3-67.1 CBoBoFAFAAACACAAAAAFACAAAABAAAABABABCAAA
ABA
ACAAAABAAAABABABCAAAFBBB
Progenitor CBoBoFAFAAACACAAAAAFACAAAABAAAABABABCAAAFBBB
S3-67.2 CBoBoFAFAAACACAAAAAFACAAAAB
AFACAAA
AFACAAA
AFACAAAABAAAABABABCAAAFBBB
Progenitor CBoBoFAFAAACACAAAAAFACAAAABAAAABABABCAAAFBBB
S3-61.1 CBoBoFAFAAACACAAAAAFACAAAABAAAABABABCAA
BCAA
BAAAABABABCAAAFBBB
Progenitor CBoBoFAFAAACACAAAAAFACAAAABAAAABABABCAAAFBBB
S3-60.1 CBoBoFAFAAACACAAAAAFACAAAABAAAABABA
FAAAAAABAAAABABABCAAAFBBB
Progenitor CBoBoFAFAAACACAAAAAFACAAAABAAAABABABCAAAFBBB
S3-60.2 CBoBoFAFAAACACAAAAAFACAAAABABAABABAB
ACAAAABAAAABABABCAAAFBBB
Progenitor CBoBoFAFAAACACAAAAAFACAAAABAAAABABABCAAAFBBB
S3-55.1 CBoBoFAFAAACACAAAA
BoBoFAFAAACA------FACAAAABAAAABABABCAAAFBBB
Progenitor CBoBoFAFAAACACAAAAAFACAAAABAAAABABABCAAAFBBB
S3-54.4 CBoBoFAFAAACACAAAAA
AF-----AB
CAAAAAFACAAAABAAAABABABCAAAFBBB
Progenitor CBoBoFAFAAACACAAAAAFACAAAABAAAABABABCAAAFBBB
S3-54.5 CBoBoFAFAAACACAAAAAFACAAAABAAA
BAAA
AABAAAABABABCAAAFBBB
Progenitor CBoBoFAFAAACACAAAAAFACAAAABAAAABABABCAAAFBBB
S3-52.2 CBoBoFAFAAACACAAAAAA
ACAAAAAFACAAAABAAAABABABCAAAFBBB
Progenitor CBoBoFAFAAACACAAAAAFACAAAABAAAABABABCAAAFBBB
S3-52.3 CBoBoFAFAAACACAAAAAFACAAAABAAAABABABC
BA---BABABCAAAFBBB
Progenitor CBoBoFAFAAACACAAAAAFACAAAABAAAABABABCAAAFBBB
S3-50.2 CBoBoFAFAAACACAAAAAFACAAAABAAAABABABCAAA
BABABCAAA---B
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Inter-allelic mutations
Donor 1
Progenitor ·····CEAAABCEAAAABCAAAABAAAEAAABAABAAFAAAAFAABoHBBB
Progenitor CBoBoFAFAAACACAAAAFA-----------CAAAABAAABABCAAAFBBB
S1-51.1 CBoBoFAFAAACACAAAAFAAAEAAACEAAACAAAABAAABABCAAAFBBB
Progenitor ·····BCEAAAABCAAAABAAAEAAABAABAAFAAAAFAABoHBBB
Progenitor CBoBoFAFAAACACAAAAFACAAAABAAABA------BCAAAFBBB
S1-46.1 CBoBoFAFAAACACAAAAFACAAAABAAABAAFAAAABCAAAFBBB
Donor 2
Progenitor ·····EoEAFAEAFACAAFACEAEAABAAAAAFAAAFAAAABCAAFAAAAAFAABoACAoAAAAAB
Progenitor CBoBoFAFAAACACAAAAFACAAAABAAAAB------------------------ABABCAAAFBB
S2-66.1 CBoBoFAFAAACACAAAAFACAAAABAAAABAAAFACAAAABAAAABAAAAFAABABABCAAAFBB
Progenitor ·····FACAAFACEAEAABAAAAAFAAAFAAAABCAAFAAAAAFAABoACAoAAAAAB
Progenitor CBoBoFAFAAACACAAAAFACAAAABAAAA----------------BABABCAAAFBB
S2-58.2 CBoBoFAFAAACACAAAAFACAAAABAAAAFAACAAAABAAAAFAABABABCAAAFBB
Progenitor ·····CAAFACEAEAABAAAAAFAAAFAAAABCAAFAAAAAFAABoACAoAAAAAB
Progenitor CBoBoFAFAAACACAAAAFACAAAA--------------BAAAABABABCAAAFBB
S2-56.1 CBoBoFAFAAACACAAAAFACAAAAAAAAAABCAAAAAABAAAABABABCAAAFBB
Progenitor ·····AAFACEAEAABAAAAAFAAAFAAAABCAAFAAAAAFAABoACAoAAAAAB
Progenitor CBoBoFAFAAACACAAAAFACAAAABAAAAB-------------ABABCAAAFBB
S2-55.1 CBoBoFAFAAACACAAAAFACAAAABAAAABAACAAAAAAFAABABABCAAAFBB
Progenitor ·····AFACEAEAABAAAAAFAAAFAAAABCAAFAAAAAFAABoACAoAAAAAB
Progenitor CBoBoFAFAAACACAAAAFACAAAA------------BAAAABABABCAAAFBB
S2-54.5 CBoBoFAFAAACACAAAAFACAAAAFACAAAAAFAAABAAAABABABCAAAFBB
Progenitor ·····CEAEAABAAAAAFAAAFAAAABCAAFAAAAAFAABoACAoAAAAAB
Progenitor CBoBoFAFAAACACAAAAFACAAAABAAAABABABCAAAFB---------B
S2-51.1 CBoBoFAFAAACACAAAAFACAAAABAAAABABABCAAAFAACAoAAAAAB
Progenitor CBoBoBAoFAEAAACEAAACAFAAAAFACEAAACACAFACECC·····
Progenitor CBoBo------FAFAAACACAAAAFACAAAABAAAABABABCAAAFBB
S2-48.5 CBoBoBAAAAAFAFAAACACAAAAFACAAAABAAAABABABCAAAFBB
Progenitor ·····AABAAAAAFAAAFAAAABCAAFAAAAAFAABoACAoAAAAAB
Progenitor CBoBoFAFAAACACAAAAFACAAAABAAAA-----BABABCAAAFBB
S2-47.2 CBoBoFAFAAACACAAAAFACAAAABAAAAAAFAABABABCAAAFBB
Progenitor ·····ABAAAAAFAAAFAAAABCAAFAAAAAFAABoACAoAAAAAB
Progenitor CBoBoFAFAAACACAAAAFACAAAABAAAABABAB----CAAAFBB
S2-46.2 CBoBoFAFAAACACAAAAFACAAAABAAAABABABoACAAAAAFBB
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These pages provide supplementary information for the following publications:
Global haplotype diversity in the human insulin gene region. Stead, J.D.H., Hurles, M.E. and Jeffreys, A.J. Genome Res. 13, 2101-11 (2003)
Structural analysis of insulin minisatellite alleles reveals unusually large differences in diversity between Africans and non-Africans. Stead, J.D.H. and Jeffreys, A.J. Am. J. Hum. Genet. 71, 1273-84 (2002)
Influence of allele lineage on the role of the insulin minisatellite in susceptibility to type 1 diabetes. Stead, J.D.H., Buard, J., Todd, J.A. and Jeffreys, A.J. Hum. Mol. Genet., 9, 2929-2935 (2000).
Allele diversity and germline mutation at the insulin minisatellite. Stead, J.D.H. and Jeffreys, A.J. Hum. Mol. Genet., 9, 713-723 (2000).
If you refer to these data, please cite the relevant publication.
Last updated: 8 September, 2005
Celia A. May
The views expressed in this document are those of the document owner, John D.H. Stead.
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