Allele frequencies at polymorphisms flanking the insulin minisatellite

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SNP    Allele                             Frequency
              Ivory Coast Zimbabwe    Kenya       UK         Kazakhstan  Japan

INS-1  C      0.20        0.15        0.19        0.44       0.59        0.59
       T      0.80        0.85        0.81        0.56       0.41        0.41

INS-2  A      0           0.01        0           0          0           0
       G      1           0.99        1           1          1           1

INS-3  C      0.98        0.96        0.96        1          1           1
       T      0.02        0.04        0.04        0          0           0

INS-4  C      0.12        0.10        0.10        0          0           0
       T      0.88        0.90        0.90        1          1           1

INS-5  C      0.90        0.91        0.93        1          1           1
       T      0.10        0.09        0.07        0          0           0

INS-6  A      0.01        0.01        0           0.005      0           0
       G      0.99        0.99        1           0.995      1           1

INS-7  C      0.34        0.29        0.24        0          0           0
       G      0.66        0.71        0.76        1          1           1

INS-9  A      0.19        0.19        0.17        0.69       0.86        0.97
       C      0.81        0.81        0.83        0.31       0.14        0.03

INS-10 C      0.79        0.82        0.76        1          1           1
       T      0.21        0.18        0.24        0          0           0

INS-11 C      1           1           1           0.77       0.93        0.98
       T      0           0           0           0.23       0.07        0.02

INS-12 C      0.99        0.96        0.99        1          1           1
       T      0.01        0.04        0.01        0          0           0

INS-14 C      1           0.99        0.96        1          1           1
       T      0           0.01        0.04        0          0           0

INS-16 A      0           0.01        0           0          0           0
       G      1           0.99        1           1          1           1

INS-17 A      0.01        0.04        0.01        0          0           0
       T      0.99        0.96        0.99        1          1           1

INS-18 A      0.96        0.93        1           1          1           1
       G      0.04        0.07        0           0          0           0

INS-19 C      1           0.99        1           1          1           1
       T      0           0.01        0           0          0           0

INS-20 C      0.97        0.94        1           1          1           1
       T      0.03        0.06        0           0          0           0

INS-21 A      0.54        0.57        0.60        1          1           1
       C      0.46        0.43        0.40        0          0           0

INS-24 C      0.49        0.51        0.56        1          1           1
       G      0.51        0.49        0.44        0          0           0

INS-25 A      0           0.01        0           0          0           0
       G      1           0.99        1           1          1           1

INS-69 +      0.26        0.27        0.23        0          0           0
       -      0.74        0.73        0.77        1          1           1

INS-26 A      0.02        0.06        0.10        0          0           0
       G      0.98        0.94        0.90        1          1           1

INS-27 A      0.19        0.19        0.15        0.72       0.88        0.95
       T      0.81        0.81        0.85        0.28       0.13        0.05

INS-72 C      1           1           1           1          0.96        1
       T      0           0           0           0          0.04        0

INS-70 A      0.03        0.06        0           0          0           0
       G      0.97        0.94        1           1          1           1

INS-28 C      0.71        0.74        0.74        1          1           1
       T      0.29        0.26        0.26        0          0           0

INS-31 C      1           0.97        1           1          1           1
       T      0           0.03        0           0          0           0

INS-32 C      0           0.01        0           0          0           0
       T      1           0.99        1           1          1           1

INS-34 C      0.25        0.28        0.21        0.77       0.93        0.96
       G      0.75        0.72        0.79        0.23       0.07        0.04

INS-35 C      0.94        0.91        0.93        0.95       0.95        0.99
       T      0.06        0.09        0.07        0.05       0.05        0.01

INS-36 A      0           0.03        0           0          0           0
       G      1           0.97        1           1          1           1

INS-37 C      0.97        0.99        0.96        1          1           1
       T      0.03        0.01        0.04        0          0           0

INS-38 C      0.94        0.99        0.93        0.77       0.93        0.96
       T      0.06        0.01        0.07        0.23       0.07        0.04

INS-39 A      0.81        0.81        0.86        0.28       0.13        0.05
       C      0.19        0.19        0.14        0.72       0.88        0.95

INS-40 C      1           1           1           0.77       0.93        0.96
       T      0           0           0           0.23       0.07        0.04

INS-41 G      0.92        0.98        0.92        0.77       0.93        0.96
       T      0.08        0.02        0.08        0.23       0.07        0.04

INS-42 A      0.08        0.02        0.08        0.23       0.07        0.04
       G      0.92        0.98        0.92        0.77       0.93        0.96

INS-43 C      0.03        0.06        0           0          0           0
       G      0.97        0.94        1           1          1           1

INS-45 C      0.99        0.99        1           1          1           1
       T      0.01        0.01        0           0          0           0

INS-49 A      0.75        0.71        0.77        0.72       0.61        0.60
       T      0.25        0.29        0.23        0.28       0.39        0.40

INS-71 +      0.75        0.71        0.77        0.72       0.61        0.60
       -      0.25        0.29        0.23        0.28       0.39        0.40

INS-51 C      0.54        0.38        0.61        0.72       0.61        0.60
       G      0.46        0.62        0.39        0.28       0.39        0.40

INS-52 A      0.12        0.09        0.11        0.05       0.04        0.01
       G      0.88        0.91        0.89        0.95       0.96        0.99

INS-53 A      0.24        0.29        0.23        0.28       0.39        0.40
       C      0.76        0.71        0.77        0.72       0.61        0.60

INS-54 C      0.26        0.29        0.14        0          0           0
       T      0.74        0.71        0.86        1          1           1

INS-73 C      1           1           1           0.96       1           1
       T      0           0           0           0.04       0           0

INS-56 A      0           0.03        0.01        0          0           0
       G      1           0.97        0.99        1          1           1

INS-74 A      0.01        0           0           0.09       0           0
       G      0.99        1           1           0.91       1           1

INS-57 A      0.98        0.94        0.90        1          1           1
       G      0.02        0.06        0.10        0          0           0

INS-60 A      0.01        0.04        0.01        0          0           0
       G      0.99        0.96        0.99        1          1           1

INS-63 C      0.74        0.71        0.86        1          1           1
       T      0.26        0.29        0.14        0          0           0

INS-64 C      0.02        0.06        0.10        0          0           0
       G      0.98        0.94        0.90        1          1           1

INS-65 C      0.26        0.29        0.14        0          0           0
       T      0.74        0.71        0.86        1          1           1

INS-66 C      0.78        0.78        0.86        1          1           1
       T      0.22        0.22        0.14        0          0           0

INS-67 A      0.03        0.01        0.07        0.34       0.27        0.16
       G      0.97        0.99        0.93        0.66       0.73        0.84

INS-68 A      0.03        0.01        0.01        0          0           0
       G      0.97        0.99        0.99        1          1           1

These pages provide supplementary information for the following publications:

Global haplotype diversity in the human insulin gene region. Stead, J.D.H., Hurles, M.E. and Jeffreys, A.J. Genome Res. 13, 2101-11 (2003)

Structural analysis of insulin minisatellite alleles reveals unusually large differences in diversity between Africans and non-Africans. Stead, J.D.H. and Jeffreys, A.J. Am. J. Hum. Genet. 71, 1273-84 (2002)

Influence of allele lineage on the role of the insulin minisatellite in susceptibility to type 1 diabetes. Stead, J.D.H., Buard, J., Todd, J.A. and Jeffreys, A.J. Hum. Mol. Genet., 9, 2929-2935 (2000).

Allele diversity and germline mutation at the insulin minisatellite. Stead, J.D.H. and Jeffreys, A.J. Hum. Mol. Genet., 9, 713-723 (2000).

If you refer to these data, please cite the relevant publication.

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Last updated: 8 September, 2005
Celia A. May
The views expressed in this document are those of the document owner, John D.H. Stead.