Sequence around MSTM hotspots

Polymorphisms downstream of minisatellite MS32, spanning crossover hotspots MSTM1a, 1b and 2

The sequence is taken from Release 23.34e.1 of human chromosome 1 and is orientated centromere to telomere. Coordinates are given relative to the position of the centre of minisatellite MS32. Alu repeats are shown in red and microsatellites in green. The locations of PCR primers used for amplification of genomic DNA and for resequencing for SNP discovery are indicated below the sequence. The alternative allele at each SNP is shown below the sequence. The approximate positions of the centres of meiotic crossover hotspots MSTM1a, 1b and 2 are also shown.

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--- minisatellite MS32 --->

60 AATGGAGCAGGTGGCCAGGGGTGACTCAGAATGGAGCAGGCGACCAGGGGTGACTCAGAA

120 TGGAGCAGGTGACCAGGGGTGACTCAGAATGGAGCAGGTGACCAGGGGAATAGACGTTAA

180 CTACTGATTAGAACTGTTGGAAAAGGTTGTTTAGTGAAACTAGGGCTGAGGAGAACGAGG

<-------- 32EN ---------

----- 32ER2 --------->

<-------- 32E -------

------- 32ER ----

240 AAGTTCAACTTTAAAATGGAGAACAAAGAACTGAACATACTGACATACTGATTCTTTGAA

--- --------- 32FR ---------->

-->

<-- LTR10A/ERV1

300 GAGAAATTTAGAACTCACTGTATTCAACAAATTATTATTTTTGCTTTTAAGTGTCTGTGG

<-------- 32C ---------- <-- 32A ---

---- 32AR --

360 AATTCACCGGTGATCCACCTGCCTCAGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCC

-------------

------------>

<-- AluSp

420 ATTGTGCCCGGCCAAGAACAGCCTTCCATTTCTACCTTGCCTGTAGCCTCCCAAACCAAA

480 ATACGGGTCTCAACACCTGGTCCTTGATCTCCTTGACTCCCGTTGGACCCAAGAAGTATG

540 GCTTCTCTCCCCTTTCCTCTGGTGGATGGCCCTGGACACAACCCACCTCACACTAACAGA

600 GACAGAGGGGTGGTCCAAGGGAAGTGAGTGAGAAGTTACCTGCAGAAGAGGGAACTTTTG

660 AGAGAAGGAACCAGGTAGCTGTGAGGCCCTTGAAAACAGAAGGCTGTCAAGGCAGATTTG

---- 32+0.6R --

720 AAGGGAGAATATATGTGAATTAGCAAGTGCAGGAGATAGAGAGAGCACTAACTATTAGAA

------> <------ 32+0.6F2 ------

AluSx -->

780 AGAAATGAAAATAGGGCCAGGCGCGGTGGCTCACACTTGTAATCCCAGCACTTTGGGAGG

<----- 32+0.6F -----

840 CTGAGGCAAGTGTATCACTTGAGGTCAGGAGTTCGAGTCCAGCCTGGCCAACATGGCGAA

900 ACCTCCCCACCATGTCTACTAAAAATACAAAAATTAGCTGGGTGTGATGGTGTGCACATG

HpC/T

960 TAATCCCAACTACTTGGGAGGCTGAGGCAGGAGAATCTCTTGAACCTGGGAGGCGGAGGC

1020 TGCAGTGAGTCAAGATTGTGCCACTGCACTCCAGCCTGGGCGAAAGAATGAGACTCCATC

STR -->

1080 AGAAAGGAAGAAAGGAAGGGAAGGGGAAAAGAAGGGAAGGGAAGGGAAGGGAAGGGAAGG

1140 GAAGGAAGGAAAGGAAGGGAAGGAAGGAAGGGAAAGGAAGAAAGGAAGGGAAGGGAAAAG

1200 AAGGGAAGGGAAGGAAGGAAAGGAAGGGAAGGAAGGAAGGGAAGGGAAGGAAGGAAGGAA

1260 GGAAAGGAAGGGAAGGAAGGAAAGGAAGGGAAGGAGGGAAGGGAAGGAAGGAAGGAAGAA

BbC/G

1320 AGGAAGGAGAAACTAGGAATAGGGAGAGGATAAAGAAATTTTAGTTTTTGAAAAAGCTGT

1380 GTTAAGCTAATCAAGTCACATGAGATCATGCAGAGATGTGGCTACCATAGTATCTAAAGA

<------- 32+1.4NNF ------

------ 32+1.4R ---->

<------- 32+1.4NF -------

<------- 32+1.4F --------

1440 AAAGGACTCTGAGGCAGGCAGCCTGCCTGGGTTCAAATCCTGCCTCCCCCACTTATTCAC

1500 TGTGCAATCTTGGGCAAGTTACCTAACCTCTGCCTCAGTTTCCTCATTTGTGATGGTTGT

1560 TGTAAGGATCAAGTTATTGCACGTAAAGTACTTAAAACAACTCCTGGCCCATTAAGCACA

1620 AGAGACCTGTGTTTTGTTCTTGTACTATCTTCCTCTTCATCATTATGTACCTATAAATTA

------ 32+1.6R ---->

1680 ACTAACCTGGATGTTACTGGCATTTCAAGATTTCCTTGCACAGTGCTAAAAGTCACTGTT

1740 CAAATTGTGCTCACAATCTGTGCACTCTTATCAGAATATGGGCAAGAAGTTGGACAGAGT

<----- 32+1.7F -------

1800 TGCCCTACTAGAGAAAGTGGGTATATAGAGAGCATCTTTTACATATTTGCATTGGGGCTG

1860 TCTTTCATCACAATGGGAGCAGAATTTGACAGGCAGTAGGGTGGATGAGGTGCAGCTCCA

<----- 32+1.8F ------

1920 CACTAACCAGCTGAGCCATGTGAGCAAATATTGAGCACATCAACCCCATTCATCATCAGG

1980 CTTTTTTTTTTTTTTTTTTTTGAGACAGAGTCTCACTCTATTGTCCAGGCTGGAGTGCAG

2040 TGGCACTATCTCAGCTCACTGCAGCTTCTACTTCCTGCTTTCAAGTGATTCTCGTGCCTC

2100 AGCCTCTCAAGTAGCTGGGAATACAGGTGCACACCACCATGCCCGGCTAATGTTTTTGTA

SfG/A

2160 TTTTCAGTAGAGACAGGGTTTCATCATGTTGGACAGGCTGGTCTTGAACTCCTGACCTCT

2220 GGTGATCCACCCGCCTTGGCCTCCTAAAGTGCTGGGATTACAGGCATGAGCCACCGAGCC

<-- Alu Sx

2280 CAGCCATCAGGCTCCCTCTAACACGTGTTTACATTTAATCATTCGATTTGCATAAATCTA

------ 32+2.3R ---->

2340 GCTTCTTGCCTGCCCTAGACATGTGTGGCTTTGTTGCAAAGCTAGACATGCTTTAAAATT

<----- 32+2.3F -----

2400 AATTTGAAATGCATGTAACTTTTGCTATCCCAAAGATGGTAATATAGCTGCATAGCATTC

2460 CTAGAGACCTCCAACACTTCCTTCCTTCCCGAACAGAGCATTTAACTCTCTTCTCAAACT

2520 ACCGACTGTCTGGGGCGGTGTGCCATGATGCCCCGGGGGAAGCTCCGTGGATCTGGAAGG

2580 CAACTCGGGACATCTGGTCTGGCCAGCCCACCCACGTAATGCATTCAGCAGACCTGCCCC

----- 32+2.6R ----->

2640 CTACACAGAGGGCTGAGCCTCTGAGCTCCCACAGGCTCTACCTTATAAGCAAAGACTGAA

2700 GAGTCTTTGTTCATAAGGAAGAGAGAAGAAAGAAAAGAAGCAATTAAACAGAATTGCAGG

2760 AGCTCCTAGAGTCTGTCAGTTTCTTCAGAGCCACGCCAGGGTCTCACCTATCTTTGTAGG

EcG/A

2820 CTGCTCAGTAGAAGTGAGGCACCCAGTGGGTGCTGGCTGAGGTCTCCTCTCCCTCGGCAG

2880 GGTCCCTTCTGATGGCCTCCCTCCTCCATCTGCAACAATCCCCCGCACCCCTGTGGGCTT

2940 CCTTCTTCCCACCACCTCTGCATGCTGGGCCCTCTGGGTTCTGTCTTCTTCCTATTGGAA

----- 32+2.9R ----->

3000 GCTCCCTTTCCAAATGACCTCCTGTCCTCTGCTGGCCCAGACCTCCCCTTATGTGCTGTG

3060 AATCCCCCATCTCCAACTCCAGCCCAGTCTCTCTTCTCAACATGCAGTGGCCGCTTCCAT

3120 CCATGTCCCCCAGGCATCCTAAATTCAGCACTTCCAAAACTGGAATTCACAGGTTTCCCA

3180 AATGCACTTGCACGCCTGGGTTCCTCATCCAGCCCAAGACACCACCTTTCCCCGACTCGC

3240 TCTGTCTAAAACCCGAGTCTTCTTCGACTTCCTTCCCTCTTTCCCTCGTGCCTAACGATA

----- 32+3.2R ----->

3300 GTAATAGTATTGCTCATATGCATTGAGTACATCCAGTGTGCTAGACAGCATACGAATCCC

3360 CAGCAGTTTCCTTTGATACACCTACTACATGAGGCAGGTACTATTATCAACAGCATTTTA

3420 TGGATGAGGAAGTGGGGTGCAGAGAGCTGGCTCGAGGGGGCAGAGCTGGTGGAGAGCTGG

----

3480 ACTGAGACTGGGATCTGTTTGATTCCAGAGCTTGAGCCTTTTGCACCACTCTGCTCCATC

----- 32+5B ------->

3540 TTTGACCGCCACACACCCTAAAAACAAAACAAAACCCAAAACACTCCACCACTGAACAAT

3600 TTTGGTGACCACCGTCCCACCTCTGGGAGGGCTGGGAGTCCCCAGAAAACACAGAAGTAG

M+3.7G/A

3660 CTCCCAGGCCCGTAATTCACCCCAACATTTTTGGTTCTAGAAACCTGGCAAAGCAGCCAC

3720 ATTGGCCCAAGCCAGCGACACCGCGCGGCCCCGCGCTTCCCACAGCCCTGGGCCCGGCAA

3780 GGCTGAAATCAAGTCTAGAAGATGGCAAGGTGGGAAGGAACGCTCCTCTTTCATCTTGCT

3840 TCAGAGAAAACCTTCGCCAGTCTCAGCATCATCAGTACACACGTGGCCTGCTCTTCAGCG

3900 GATCTCACCAGTAACACCTTCTGGCATTTGGGCTAGAGACCGGGCCCCTGAGGCCGCCCT

3960 GGGAAGCCTGAGGTGTGGAGGGGGATTCAGGATGTGCCTCTGTTCCTGTATGTGCAAGTG

degenerate GT repeat -->

4020 TGAGTATGAGTGTGTGTGTGAATGTGGAGGTGGGTGAGTGCATGAATGTGTGTGTGTGAA

4080 TTTGAGTGTCATGTGGGTGTCTCTGTATGCATGTGTGTGTGTACATGGTGTCTTTGTATG

4140 CATGTGTGTGTGTGGGTGTTGTGTGTATGTGTACGTGTGTGCATGTGTATGTAAATGTAA

4200 TTCTGTGGGTGTGTGTGAGTATATGTGTCAGAGTGTCATGTGGGTACATGGGAGTGTTGT

4260 GTGGGTGTGAGTGTGTGAGTGCTATGTGAGTGTGTGGTGTGTGTGTTTGTGTGTTATGTA

4320 GGTGTGTTTGTGGGTGTTGTATGTGTGAAGGTGGCCGTGTATGTGGGTGAGTGTTATGTG

4380 GGGGTGAGTATGTGTACGCGTGGGTGAGTGTGGGTGAGTGTTGTGTTATGTGGGTGTGAG

4440 TGTGCATGAGTGTGTGAGTGCTATGTGTGTGGTGTGAGTGTGTTTGTGTGAGAGTGTTAT

4500 GTGGGTGTCTGTGGGTGTTGCGTGTGTGAATGTGGATGTGCATGTGGGTGAGTGTTACGT

4560 GGGTGTGTGTGTGGTGTGAGTGTATGTGTGAGTGTTATGTGGGTGTTTGTGGGTGTTGTG

4620 TGCGTGAATGTGGATGTGCATGTGGGTGAGTGTTATGTGGGTGTATGTGTATGCGTGGGT

4680 GAGTGTGGTGAGTGTTGTGTCAGTGTGAGTGTCCATGAGTGTGTGGTGTGTGTGAGTGCT

4740 ATGTGAGTGTGTGTGTGGGGTCTGAGTGTGTGTGAGAGTGTTATGTGGGTGTTGTGTGTG

4800 TGAATGTGGCTGTGCATGTGTGTTATGTGGGTGTATGTGTATGCGTGGGTGAGTGTGGGG

4860 AGTGTGAGTGTGCATGAGTGTGCATGAGTGTGTGGGCACAGAATTTATCTGATCCCAAAC

4920 CATTTTCACACCTACTCTCCCATTCGGAGGCCCATTAAAGGCCCCCCAAGCACTCCCCTG

------ 32+4.9R ---->

4980 TCCCTCCCGCCTGTGGAAGGGCCGCTCCTGCTCTGAGGTCTTCTAGCACAGCCCATCTTG

5040 CACAGTGGCCATTTCCTGCTTGCATGGTAGTTATTTGTACCATTGTCTCTGCTCCTTCTA

BlC/A

5100 ACTGGACGTCTCCTGAGGACAACACAGCGTCCGGTCTGTCGTTGTCTTCCCGAAGCCACC

AluJo -->

5160 AGCACACAGTAGGTGCTCAACAAATAGCTGGTGAAGGCTGGGCACGGTGGCTCACACCTG

<----- 32+5.1F -----

5220 TAATCCCAGCACTTTGGGAGGCCAAGATACGAGGATTCCTTAAGCCCAGGAGTTCGAGAC

5280 CAGCCTGGTCAACATAGCGAAGCCCCGTCTCTGTTTAAAATGTATATAACTGGTGAACTC

M+5.4G/A

5340 GTATCAACCCACCCCCCAGCTCAGTGTTCTCCACAGAGTCCTTGGGGGTGTTTTCTCTCC

5400 CCTACATTTCTGCTTTCAGCCCCAGAAACACCTGCCCCGGCAGCCTGGGGTGGGTGGGTG

5460 GGACAGCAGCTCCCTGCAGGCTTTGGTGAGGGTGGCCCCACCCGGAACTCCACATGAGGT

5520 CAACCTCCCTGGTCTGCAAGTCATCACAGAGAGGCTGAGAACCTGGCTGAGGCACTGGAG

5580 GGGCCGTGCGCGGTGACGGGACGCGCTCAGCCTTCTAGGGGCCTCAGTTTCCCCTCTTGG

<-----

5640 CACTAGGAGCAGCACCTTCCCACCCACTTCACAGGCCGTTGCAAGATGATAGCGGCGGCA

-- 32+5.6F --- <----- 32+5.7F -----

5700 GCTTTTGAAAAGCTCTGAATGATATCAGACAACAAATCACAGCACTGAAAAAACAGGTCT

5760 AGTGCTTTCGGTGTGAGAAAAGGTTATTTTTCAGTGTGCTGAAATACTGTACGGCAATTA

5820 AGTTGCTGAAGATGGATTTGAATGAACTAAAACTTAAACGTGGCAGAGAGAAAGCAGCCT

5880 GAGGCATGGCTGACTCTGCTCTTTGGTGTGGAAATGAAGCCCAGCGGCCTGGGGCTTGGC

5940 CTTTGTAGATCAGCCTCCGAAGGTGAAGCTGGAATGAGGGAAGGCATCTGCCCCCAACAC

6000 CAGGTGTCTGAGGCTCTGGCCCCACCCCACAAAAGGGAGACACTCTCCAGCAAAGCTGCC

6060 GCTAAGCAGGGGCTCGGCGGTGACTGCAGCTGGTGCATCTTTTCTTGTTTCCGTTTTGCT

6120 GTGGTCACTTGATTTTAGAAGTTGCTGGAGGTACCTGTCCACCCCCTCCTCAGACAAGGG

6180 GCTGGGTTGGTTTGCAGGTAGAATCACTTTCCCTTTTCTCTGGACTTGATTTTCAGGCCA

6240 GTGGACTTGCGCAGCCTTTGTTTTGGCTGTTGTCCCTTCTCTAGTCCTTGCTATGTTGCT

6300 GAATATTAGCACAGTATTTGTAAGGGAGGGTGGGTTGGAGTAGAATGAAAATTCAACCAT

6360 TTTTGCCTGACAGCAGATTTGATAGAAGTTTTAGTAGAGGAGAAGTTAGAATTTAACTCA

6420 TGATTCATTAAATATATGTTTTCTATATTTCTTCTTATAAGAGATTTTCGACATCAATCA

6480 TGTATCAAAGAACAGAATATACATACAATTTCCATTTTGTCAGTTTTATCCAATTCATCC

6540 ACATCATGCAGAAACAGAAGTTTCCAGTAGATGGCGCCAAAGTCTGTCTTTTCTCCGCCT

6600 CCCTGCGCGCTCTTCGTTGTTTCAAGATCCGCACATCAACCAACCCTCCAGAAAATGACA

6660 TTTCTTTATCAGCGCAGACCAGCACGAGGTGCTCTCCACAGCAGAAAATCCCAGTAAGAT

6720 GTCTGGCAAGAAAAATAGCCCCAAGAGTTGTAGCCCTGGGCAGTAAAACCAGAAGCCAGG

6780 AATCCTGGTTTCCAAACAGTTGATGGGTTTTGTGCCAGTTCAGTTTTGAAGCAACGGCCC

6840 TGCGGTACTGAGGGTCAGAGCCGTCTCCCATCTGCTCCCTCTCTTCCTCCCACTGGCCCC

6900 CATGGAAGCAGCTGCCCAAGCTTCTTGAGAAGGTGAGTGCCGGAACTCCAGGACAGGAAG

AluY -->

6960 AAGACTCTAAGCTTGGTCTTAAAAGACCACAAAGCGGCCTGGCGCGGTGGCTCACGCCTG

7020 TAATTCCAACACTTTGGGAGGCCGAGGCGGGCTGATCACGAGGTCAGGAGATCGAGATCG

7080 TCCTGGCTAACACGGTGAAACCTCGTCTCTACTAAAAATACAAAAAATTAGCCGGGCGTG

7140 GTTGCAGGCGCCTGTAGTCCCAGCTACTCGGGAGGCTGAGGCAGGAGAATGGCCTGAACC

7200 CGGGAGGTGGAGCTTGCAGTGAGCTTGCTGGATCACTCCAGCCTGGGCGACAGAGCGAGC

7260 CTCCATCTCAAAAACAAACAAACAAAAAACACCACAAAGCATGAGATCCAACAGCCTGGG

AluJo/Jb -->

7320 CAACATGGCGAGGCCTTGTCTCTAGAACAAAATTTTAAATTAAAAAAATTAGCCAGACAT

7380 AGTGGTGTGCTTGAGCCGTAGAGGTCAAAGCTGCAGTGAGCTGTGATTATGCCACTGCAT

7440 TCCAGCCTGGGCAATAGAGTAAGACCCTGTCTCAACAAACAAACAAACAAAAAGCCAAAC

7500 AAACAAAACCCCACGAGATCCTAAGGTTCCCATGGCCTTTCTTCTTGCACTGGGCCCATG

7560 ACTCTGCCTCAGGCTGTGACCGGGACATGAATGGAGAGGAAGGAAAGGGAAATGGTAAAG

7620 GGGGCAGGATTGTCTCCAAGTACTTCCCCAGGTCCAGGGGAAGAGGGCTGGCAGGTGAGG

7680 AAACCAGAGAATGGGAAACCCAGGCTGAACCCTGATGTTGAGCCCGAACGCTGATGCACT

7740 GCCGTCTGTGTGCATAGCACAGTGAAAACTGCAAAGAGATGTGGTTCCTGGCCTCCAGGA

7800 ATTAACGATCAGGTGGAAAGAAAGTTCATTCCACCCAGGGATGCGTTGGAGCCAGCTAGC

7860 ACCTTTGAGCTGATTGTGCACGTCTCTACACAATGACACCATGACGTTGTGTCAGTAGTT

7920 TCAAATCCGCCATGTGGCAGTATTCACACCAGAGAAATCAGCGAACTCCACAAATCAGGG

7980 CTCCCTCCACTCCCCCAGAGCTGAACTTTAAACATTTACCTGCATGCTGGTGACTCTGCC

8040 TCACTATAGCACAAACTGCTTAAATAAAGGTGGGGCGGGACATTTGGTCACAGTCGGGAA

8100 GCAGTTGAAAGTGTCATGGGTTTGAGTCTAAGGTCAAGCTCTTCCGCTGATTGACTATCT

8160 GACCCTGATTATCTCCACCTCAGCCTCTGCCTCTCTTTAATGAGACTGATGCTATCTACC

8220 CTAGTTAGTTACAGAGTGGCTGGGAGGCTTAAATGAGATCGGTCTGTGTGGATACTATGT

8280 AAATTATAATGGATTTTATCAAGGTAATAGATGCAGCTTTAAAACATTCATAAAATTATG

8340 AGAATGAGGCCTACCAAATCCCAGTTTCATAAGGATACATATGATAATGCATATTTGTTT

8400 GATTTCCCATTTATTTAATAACACTTATTGACACTACCCATATGCTAGACGCTGCTAGTT

8460 GGGCAGTCTTAAGAGAAGATGTAAAAACACTTTGTAGATTACAAAGCTTTTTTTTTTTTT

8520 TTTTTTTTTTTTGAGATGGAGTCTCACTCTGTCGCCCAGGCTGGAATGCAGAGGCGTGAT

8580 CTTGGCTCACTGCAACCTCTGTCTCCAGGGTTCAAGTGATTCTCCTGCCTCAGCCTCCCA

8640 AGTAGCTGGGACTACAGGCATGCATCACCACACCCAGCTAATTTTTGTAGTTTTAGTAGA

8700 GATGGGGTTTCGCCGTGTTGGCCAGGCTGGTCTCCAACTCCTGACCTCAAATGATCCGCC

<-- AluSx

8760 TGCCTGGGCCTCGCAAAGTGCTGGGATTACAGGTGTGAGCCACTGCACCCGGCTGATTAC

8820 AAAGTTGTTTTTTTTTTTTGGTTTTTTTTTTTTGAGATGGAGTCTTGCTCTGTCACCCAG

8880 GCTGGGTGGAGTGCACTGGCGCAATCTCGGCTCACTGCAAGCTCCGCCTCCTGGGTTCAT

8940 GCCATTCTCCTGCGTCAGCCTCCCGAGTAGCTAGCTGGGACTACGGGCGCCCACCACCAC

9000 GCCCGGCTAATTTTTTTTGCATTTTTAGTAGAGACGGGGTTTCACCGTGGTCTCGATCTC

<-- AluYc

9060 CTGACCTCGTGACCCGCCCGCCTCGGCCTCCCATACAAAGCTTTTATACAAGTCTTTTGT

9120 AAAGTAGAAGGCATCATGCAAGGAAAAATGTTGTTTTTCTCAGCTTTCTTCATCTTTTCC

9180 AATCTGGACACACATTTTCACTGCAACTAATATTATACCGATACTTTCATTAGACTAAAA

9240 TACCTGGCAGCGGTCACAGACAATGGTGTGGAAAGGAAACCAAGACAAGAAAACATCCTT

AluYc -->

9300 GCAATATTTGGCTGAGGCAGGAGAATGGCGTGAACCCGGGGGGCGGAGCCTGCAGTGACC

9360 CGAGATGGCGCTACTGCACTCCAGCCTGGGCGACAGAGCGAGACTCCATCTCAAAAAAAA

9420 AAAAAAAGGCCATAATAAAATTTATACAAAATTATTTCTATGTATGCCTATATGAATAGG

9480 GAAGAATATACATAAAGATATTCACAGTGGCTATCTCTAGGTGGTAAGATTATTTTAATT

9540 AGCCTTTCTTGCTCATATGTAATTTTTATTTTCTCTACAAAAATTGGCTACGAAATTTTG

9600 GAGATAAAAACTGAGAAGTAAAAGATCTTCATGCAGCTATTTATTTTGTAGAATTACAAA

9660 TATGGATATGAAAGGAGCCTTACAGGTCATCTGGTTTCATAAGATGGGGAAACTGAGGCT

---------

9720 GAGGGAGATGGGAAGGAAATAACTGAGGACTTTGAGTTTTCTCTGAATTTGCATTCTCTT

- 32+9.6R->

9780 TTTTCTCTCCAAATGTGTGTGCGGAGCTTTTGATAATTAATCTAAACCTGTATACTCTAC

9840 AATGAGATTCTCATCTTTCATTATCTTTCTGACTTTTTGATGTATCTGCTTCCTCTGGTA

9900 TGGTCATTTGTCTTTGCCTTGTTTCTAATTTTTTTTTTTTTTTTTAACATTCAACTGACT

9960 GCTTGGTTTCTCTTTTCTTTGAAAGACTCTTGATGTAAATAAGCCCTTTATCCCTATCTG

10020 GCCTCTTTAATTATATCTTCTCACGTTTGCTTTCTGCTCTCTACCGACTAATTTCTCAGA

10080 AATTTGCAAGGGTGAATCACAATGCCTCCAAGCCATGATTCCCAGAATCAGAAAATTGCT

<------ 32+10F --------- ----- M+10.1R ----->

------- 32+10R -------->

10140 TTTTAAATTTGAGGTAGACTGAAACGTTTTTCATCCACGTATAGTATATGATCGAATACA

10200 CCAGCCTTTGCTTTCTGGACCTCAGCGTTTACATCTGCCAGGTGGATGTTTTCCCAGCTT

10260 GCATGATGACTGCTTCTTGTTGAAAGCATCTTGGAAAATCTGAAGCCCTTTCCACCTCAA

--> AluJo

10320 CAGCACAGGCTGGGCTGGTGTGCTGGGCTCATCCCTGTAATTCCAGCTGTTTGGGGGACA

10380 AAGGCAGGAGGATTACTTGAGTCCAGGAGTTCAAGACCAGACTGGGCAACACAGTGAGAC

M+10.4G/A

10440 CCTATCTGTGTTAAAAATAAATTAGTCGGGCATGGTGGTACATGGCTGTAATTTCAGCTA

10500 CTTATGAGGCGGAAAGATTGCTTGAGCCCAGAAGTTCGAAGCTGCAGTGAGCTATGATCA

10560 TGGCACTGCACTCCAGCCTGGGCAACAGAGTGAGATCCTGTCTCAAAGCAAACAAAAACA

--> AluSx

10620 GCATGAGGCTGGGTACAGTGGCTCATGCCTGTAATCCCAGCACTTTGGGAAGCCGAGGGG

10680 GGGCAGATCACTTGAGGCCAGGAGTTCGAGACCAACCTGGCCAACATGGTAAAACCCTAT

10740 TTCTACTAAAAAATACAAAAATTAGCCATGTGTGGTGGCACATGCCTATAATCCCAGCTA

10800 CTCGGGAGGCTGAGGCATGAGAATCACTTGAGCCTGGGAGGCGGAGGTTGCAGTGAGCCG

10860 AGATCATGCCACTGCACTTCAGCCTGGGCAACAGAGTGAGACTCTGTCTCAAAAACAAAA

10920 AACAAAACAAAACCAAAACAGCACCAGATACTTGACTGCTAGATTGCACATGAGCAAATG

10980 GATTTGGGGCTAGAGATTGCGAAAGAAGCCTAAGCCACCTTCCAAGATGTGAAGTGTTGG

11040 GCTGCACACAGGGAAAGTCCAGAGAGGCAGGGTGAAACATCAGAACAAGTGACTTTGACT

11100 CCTGTTTTTGTTGAAGCCTCTCTGTGACACACAGTTATCCAGCTTGGAACATCTCTGGGT

11160 ATAGTTTGGCTCCTTATCTGTGGCCTCTTCGAAAAGTGTCAATCATGAGGGTTGAAACAC

11220 CCGCCTACATACACACACACTTAGTGAATGAATTGACACAAGCCTCCAGATTCTTTTTTG

11280 AGAGTAGAATAGCACTCACTGTCCAATAGAAATATGATGCAGGCCCCAAAGCTGAGCCAT

11340 ATATGCAATTTAAAGTTTTTAGCAGCTTCTTTTTTTCTTTTTTTTTGAGACGGAGTTTTG

11400 CTCTGTCGCCCAAGCTGGAGTGCAGCAGCACGATCTCAGCCGATCTCAGCTCACTGCAAT

11460 CTCCGCCTCTTGCACCCAAGCGATTCTCCTGCCTGAGCCTCCCAAGTAGCTGGAATGACA

11520 AGTGTGCACCACCATGCCCTGCTAATTTTTGTATTTTTAGTAGAGACAGAGTGTTGCCAT

11580 GTTGGCCAGGCAGGTCTCGAACTCCTGACCTCAGGTAATCACCCCGCCTCGGCTCCCAAA

<-- AluSx

11640 GTGCTGGGATTACAGGCATGAACCACTGCATCTGGCCATTAGCAGCCTCATTTAAAAAGG

11700 TAAAAAGAAATATGACAATAATTATAATAACATAATCAATATTTTAAATGATTGTTGAGG

AluSp -->

11760 GCTGGGCACGGTGGCTCACGCCTGTAATCCCAACACTTTGGGAGGCCGAGGCGGGTGGAT

M+11.8A/G

11820 CACCTGAGGTCAGGAGTTCAAGACCAGCCCGACCAACATGGAGAAACCCCATCTCCCCTA

11880 AAAATGCAAAATTAGCTGGTCGTGGTGGTGCATGCCTGTAATCCCAGCTGCTCAGGAGGC

11940 TGAGGCAGGAGAATCGCTTGAACCTGGGAGACAGAGGTTGTGGTGAGCCGGGATTGCGCC

12000 ATTGCACTCCAGCCTGGGCAACAAGAGTGAAAGTCCATTTCAGAAAAAAAAAAAAATTGT

12060 TGGAGTATTTTACATTCTTTTGCACCTACTAAGTCTTCAAAACCCAGTATGCCTTTTACA

M+12.2C/T

12120 CTGAGGGCGCGTCTCCATTCCAACTAGCCACAGCTGAAGTGGTCAGCAGCCACATGGGGC

12180 TGGCGGCCTGCAGGCCGGACAGCACCAGTCCAGGTGTATCCAGCGAGTTGCTGAGGATGG

12240 CAGGATGGAAAGGAGGAGTGTGAAATCGTGCCTGGAATGTCCAAGCGGATTTAATCTTAT

12300 TGGTTAAAGATGTCCACTAGGTGGCGATATATGCAAGGAATGAAAATTTACTATGTGGCT

12360 GACATTGTTAATATATGCAATTATTTGTAGATATAATTCAGTATTTCCATCATCCCTGCA

M+12.4G/A

12420 AGATGAGTAACAGGATGTTCACTTTGCGGATGAGGAAAATGAACCTTAAGCAACCTAGGC

12480 GTCTGGTGAAAGGGTTTCCAGCCAGCAACCGGAGGAGGCAGGAATCATGCCAGGTGTGTC

12540 TGGTGCCGGAGCCCAGAGGCTTCCCAGATCCGCACACTTCATGCTCACTCATCTGCCAGC

12600 CACACAGAGGTCCTGGATGTCTGGTGGGCGATGAGCAAGCGACAGAGAGTCCGTGTGATG

12660 AGGTTGCTCAGGCTGATGTGACAACAGTGAGAAGAGGCGTCTCATCTCATCCCTAACCAG

12720 ACGGGGTTAGGGATGGCGTCTTGGAGCAGCCAACCGGAGAGATTGACATCGCTGATAAAG

12780 AGGTAGATTCACACGACCTCATCTTTGTCAGTGCACAAAATGGCTCCCTACAGCCCACTG

12840 GTGACCCGGCTGCAGAAAGCTCTGGGTGTGCGGCAATACCATGTGGCCTCAGTCCTGTGC

12900 CAACGGGCCAAGATGGCGATGAGCCACTTTGAGCCCAATGAGTACATCCACTATGACCTG

12960 CTAGAGAAGAACATTAACATTGTTTGCAAACGACTGAACTGGCCTCTGACCCTCTTGGAG

13020 AAGATCGTGTATGGACACCTGGATGACCCGGCCAGCCAGGAAATCGAGCAGGGCAAGACA

13080 CCTGTGGCTGTGGCCGGACCACGTGGCCATGCTGCAGTTCATCAGCAGTGGGCTGCCCAA

M+13.2G/A

13140 GGTGGCCATGCCGTCCACCATCCACTGTGACCATCTGAAAGAGGCCCAGCTCGGAGGCGA

13200 GAAAGACCTGCGCCAGGCCAAGGACATCAACCAGGAAGTTTATAATTTCCTGGCAACTGC

13260 AGGTGCCAAATATGGCGTGGACTGCTGGAGGCTTGGATCTGGAATCATTCATTAGATTAT

13320 TCTGGAAAACTATGCATACCTTAGGGTTCTTCTGATTGGCACTGACTCCCACACCCCCAG

13380 TGGTGGCGGCCTGGGGGGAATCTGCATTGGAGTTGGGGGTGCCGATGCTGTGGACATCAT

13440 GGCTGAGATCCCCTAGGAGATGAAGTGCCCCAAGGTGATTGGCATGAAGCTAACAGGCTC

13500 CCTCTCCAATTGGACCTCACCCTAAGACGTGATCCTGAAGGTGTGGCAGGCATCCTCAAA

M+13.6G/A

13560 GTGAAAGGTGGCACAGGTGCAATCGTGGAATACCACAGGCCTGGCGTAGACTCCATCTCC

13620 TGTGCTGGCATGGCGACAATCTGCAACATGGGCGCAGAAATTGGGGCCACCACTTCCGTG

13680 TTCCCTTACAACCACAGGATGAGGAGGTACCTAAGCAAGACGGCCGGACAGACATTGCCA

13740 ATCTAGCTGATGAATTCCAGGATCACTTGGTGCCTGACCCTGGCTGCCATTATGACCAAC

13800 TAATTGAAATTAACCTCAGTGAGCTGAAGCCGCACATCAATGGGCCCTTCACCCCCGACC

13860 AGGCTCACCCTGTGGCAGAAGTGGGCAAGGTGGCAGAGAAGGAAGGATGGCCTCTGGACA

13920 TCCGAGTAGGTCTGACTGGTACCTGCAACAGTTAAAGCTATGAAGATCCCGGGCGCTCAG

13980 CAGCTGTGGCCAAGCAGGCACTGGCCCATGACTTCAAGTGCAAGTCCCACTTCACCATCA

14040 CTCCAGGCTCCGAGCAGATCCACGCCACCATTGAGCGGGACAGCTACGCACAGATTTTGA

--------

14100 GGAATGTGGGTGGCATCGTCCTGGCCAATGCTTGTGGCCCCTGCATTGGCCGCTGGGACA

- M+14.1R ->

14160 CGAAGGACATCAAGAAGGGGAAGAAGTACACAATCGTCACCTCCTACAACAGGAACTTCA

M+14.3G/A

14220 CGGGCTGCAATGATGCGAACCCTGAGACCCATGTCTTCGTCACGTCCCCAGAGATTGTCA

14280 CAGCCCTGGCCATTGTGGGAATCCTCAAGTTCAACCCAGAGACCAACTACCTGATGGGCA

M+14.4C/T

14340 AAGATAGGAAGAAGTTCAAGCTAGAGGCTCTGGATGCAGACGACCTTCCCCAAGAGGAGT

14400 TTGACCCAGGGCAGGACCCCTACCAGCACCCCCCACAGGACAGCAGTGGCCAGCACGTGG

14460 ATGTGAGCCCCACTAGCCAGCGCCTGCAGCTCCTGGAGGCTTTTGACAAGTGGGATAGCA

M+14.5C/T

14520 AGGACCTGGAGGACCCGCAGATACTCATCAAGGTCAAAGGGAAGTGTACTACTGACCACA

14580 TCTCGGCTGCTGGCCCCTGGCTCAAGTTTTGTGGGCACTTGGACAACATCTCCAACAACC

14640 TGCTCACTGGTGCCATCAACATTGAAAACAGCCAGGCCAACTCCGTGTGCAGTGCCAACA

----- M+14.7R -----> ----

M+14.7+/-

14700 TTGAAAACACCCAGGAGTTTGGCCCCGTCCCTGACACTGCCCGCTACTACAAGAAACATG

--GT---

14760 GCATCAGGTGGGTGGTGATCGGGGACGAGAACTCGAGCCGGGAGCACGCAGTGCTGGAGC

M+14.8A/G

14820 CTCCCCACCTCTGGGGCCAGGCCATCATCACCAAGAGCTTTGCCAGGATCCACAAGACCA

M+14.9A/G

14880 ACCCGAAGAAGCAGGGCCTGCTGCCCCTGACTTTTGCTGACCCAGGCGACTACAACAAGG

14940 TTCACCCTGTGGACAAGCTGACTATTCAGGGCCTGAAGGACTTCGCCCCTGACAAGCCCC

15000 TGAAGTGCATCATCAAGCACCCCAATGGGACCCAGGAGACCATCCTCCTGAACCACACCT

15060 TCAATGAGATGCGGATCAAGTGGTTCTGTGCCGGCAGTGCCCTCAACAGAATGAAGGAGC

15120 TGCAGCAGTGAGGGCAGTGCCTCCCAACACACCCCCAACCTCGCCCCCCAGAGCTGGCGT

15180 CATGTTCAAGTTCAGCTCCACATGCGCCATCAGCAGATCCGATCCATCCAGCCATGGGTT

15240 CTGATTCCAAGATGGTGTGACCAGACATGCTTCCTGCTCCCCGCTCAGCCCACAGAGTGA

15300 CTGTGGTTGGGGGAGGTTCTTAAAATAACTTTTTAGCCCCTGCCTTCCTATTTTTAGTGT

15360 TTGGTTCCAATCTTAAGCAGCTCCATGCAACTGTATTTATTTTTATTGACAAGACTCCCA

15420 TCTAAAGTTTTTCCCCTGCCTGACCATTTTATTGGTGGCTGAAGGATTCTAGAGAACCTG

M+15.5C/A

15480 TTGTTCTTGTAAGGAAAACAAGAAGCCAAAAAAAAAAAAAAAATTAAAACGGCAGATTCA

M+15.6A/G

15540 GCAAGCTGCTGTGGGGAGGTGTTAAGGGCAGCTGTTTGGGGGATCGCACATAACACCACA

15600 TGGCTAGAATAGGGTCCAGGGTCCAGGGTATGCTGTGGGGTGAACATGTGGGGTGAGAGC

15660 AGTAGACATGTCTGCAGTGGGCACAGCACCGAGGGTATTCTACCTCCAGAGCAGTGGGAT

15720 TTAAGCAGGTGATTGATATGAAGAGTTTTACTACTTAGAGGGCTCCAGACCCCAGATGCA

M+15.8C/T

15780 GAGCGTTGAGCAAATGAGGCACCCTTTGCAAATTTGAATGACAAGTTTAACCACACGCAG

15840 TTACCCTGCAGCGTAGGACCTGTCCTAGCCAACAGAACAGAGCAAGAGTTCTGGAAGGTG

15900 TTTGATGTTTGCACCATATGCTGCGGAGTCCCACAAATCTAAACTCAAGCTCTGGCTTTG

15960 CCATTCACTAGTACCATAACTTCCGGCAACCCTTAATTTCTGTATCATAAAGTAGGAATA

16020 ATGCTGGGATCAGTGGGTTGAGCTGCTGTGAGGATTAAATGAAGCATTGCTTGCAAGGTC

<--- M+16 1F ---

16080 ATGTTACCAAAGCAGTCCCACAGTGGAGTGTTCAGGACCACGAGTGGATGGCGGCACCAG

----

16140 ACTCTGAAATTCTCCTCCGGTCCCCTCCTGTGTCGCACGTACGTCAGCACGTGGCCGGGC

M+16.2T/C M+16.3G/A

16200 GTGGATACCTGCCTCATGAGCCACGTGTTCATTCAGGAACTATTCCGACCTTACACACCA

C A

16260 GGCCCTGGGCAGGGAAAGATGCTGCCTTCATGGAGCTGATAGCCTGGTCGGGGAGATAAA

16320 TGGTAGTTAAATGACACAATGAATATATAAATAGAACCATGACAAGTGTTTCAGAGGGGA

16380 ACCCTGTGTTCTAATTGGGGAGGTAGAGAAATGCTTGCTTGGTGTGTTAGTTTCCCAGCA

16440 CTGTCATGACAAAGTACCACAAACTGAGGGGCTTGAAACAACAGGATTTTATTCTCACAG

16500 TTCTGGAGGCTGGAAGATCGAGATTGAGGTTAGGCAGGGCCGTGCACCCTCTGGAGGCCC

16560 TGGGGGAGGCTCCTTCCCGGCCCTTTCCCAGCATCTGGCATTGCTGGCAGCCCTTGGGAT

<----- M+16.6F -----

M+16.6G/A

16620 TCCTTGGCTTGTAGATGTGTCACTCCAGTCTCTGCCTTTGGTGTCACAGGAACTTCTCCC

M+16.7G/A

16680 CTCTATCTCTGTCTGTGTCCAAACATATCTTTCCTTTATACAAACACCAGTCATTGGATG

16740 TAGGGTTCCTACTCCAGCATGACCTCATCTTACCTTGATTATATCTGCAAAGACCCCATT

<---- M+16.8F ------

16800 TCCAAATAAGGTCACTTTCACAGCTACAGCGGGGGGCAGGGTTGGGACTTCAAAATATCT

16860 TTTGGGGGAACACAAAAGATATATTGATATATATATTTCCCCTACATCATTTGGGGAAGT

-------

M+16.9T/A

16920 GATATTTGAGCCAAGATCTGCAGCTTGAGAAAATCTTATCCAGTCAAAGAGGTCAGGAAG

-- M+16.9R ---> A

M+17.0A/G

16980 CAGGTTCTGGGCAGGATGTGGCCTGTGCAAAGGCCCTGGGGCAGGAGGGAGCACAGCACC

----- M+17.0R -----> G

----- M+17.0aR ---->

17040 TACAAGGGACTGAGCAAGGGCAGAGGAAGGGATGGGCTTTGGGCACTGATTATCTTTAGG

17100 AGTGAAAGAGTTGCTAGGTATTATTATTGTTGTTTCTATATAAAGGATCACACAGGACAG

17160 GTCTCAGTGCCCCGTCCTGATGTGCTGTCCAAGCTGCTCAATCTGTTTTCCTGCTGTATG

<----- M+17.2F -----

M+17.2G/A

17220 CCTCACACCCAGTTCTTTTCCCATCACGTATCATTCAGAGCAATGTGCAACCGCAAATAT

17280 TTCTAAATGGGGAGAACTCAGGCAGATGGCGCGGCATGCCTTCAGCTCAGTGCACAGACT

M+17.4T/C

17340 CTGCCCCAGACAACCCACCTGTGTGTCCACATTCCCCACTGACTGAGCACCTCCTGAGGG

17400 TGGGGGGCATATCATGTTAATATTTGTACATCCAACATTTCATGAAATGTTATGAACATC

17460 AGAGGAGTTTTATAAGTGTTTGCTAAATGTTACTGACTTAGATTTTCAGGGTGTGGCCAA

-M+17.5R--

17520 TTCCATCCGAAGGGCGTTATTTATCTTGTCACTAACCGTATCCTAGAGAAGTTATTAAGC

-------->

17580 ATCCGTCTAATTCAAAGGAAAATGGGTAGATGGTGGGAGGATTAGAGAGTGGACGCCATG

FLAM_C/Alu -->

17640 TTGGAATGCAGGGGTAGGGGAAAGCCAGCTTGCTAATCAGAATGTCAGTGAAGGCTGGGA

M+17.7T/C M+17.7aC/T

17700 GCTGGGGCTCACGCCTGTTACCCCAGCACTTTGGGAGGCTGAGGCGGGAGGATCAGTTGA

C T

17760 AGCCAGGACTAGCCTGGGGGAACACAATGAGACTGTGTCTCTACAAAAAAAAAAAAAAAA

AluJb -->

17820 TTAAATACATTAACCAGGTGTGGTGGCACATGCCTGTAATCCCAGCACTTTGGGAAGCTA

17880 AGGTGGGCAGATTGCTTGAGCCCAGGAGTTCAAGACCAACCTGGGCAATATGACAAAACC

17940 CCATCTCTACAAAAAATATAAAAATTAGCCAGGTATGATGGTGCACACCTGCAGCCCAAG

M+18.0T/G

18000 TTACTCAGGAAGGTGAGGTGGGAAGATCACCTGAGCCCAGTGAGGTCGAGGCTACAGTGA

18060 GCCGTGATGGTGCCACTGCACTCCATTCTGGGTGTCAAAGTGAGATCATGTCTCTAAATA

18120 AATAAATAAATAATTGTTCTATAGAATTTTATTGATTTAAGAAAATGTTCAGAATAGATT

----- M+18.1R ----->

AluSp -->

18180 TATAAGTAAAAAATTTAAAAGGTATATATACATAGGCCGGGTGTGGTGGCTCACTTTGGG

<---- M+18.2F ------

----- M+18.2R ----->

18240 AGGCCTTTGGGAGGCCAAGGTACGTGGATCACCTGAGATCGGGAGTTTGAGACCAGTCTA

18300 ACCAACATGGAGAAACCCCGTCTCTACTAAAAATACAAAAATTAGCCAGGTGTGGTGGTG

18360 GGTGCCTGTAATCCCAGCTACTCGGGAGGCTGAGGCAGGAGAATCACTTGAACCTGGGAG

18420 ATGGAGGTTGCAGTGAGCCAAGATTGTGCCATTGCATTCCAGCCTGGGCAACAAGAGCAG

M+18.5A/G

18480 AACTCCATCTCAGAGAAAAAAAAAAAAGGCATATATACGTGTGTGTTGATTTGTGTATAG

18540 AATAAGACATGCATTTAAAAAAAAAAAGGTAGGATTGCAAGTGGGGTTTTTTCTTTTTCT

18600 TTTCTTTTTCTTTCTTTTTTTTTTTTTTTGGAGACGGAGTTTCGCTCTTGTTTCCCCGGC

<----- M+18.6F -----

M+18.7C/T

18660 TGGAGTGCAATGGCGTGATCTTGGCTCAGCACAACCACCGCCTCTTGGGTTCAAGCGATT

start of MEID-

M+18.7aG/A

18720 CTCCTGCCTCGGCCTCCCAAGTAGCTGGGATTACAGGCATGTGCCACCAGGTCTGGTTAA

18780 TTTTTGTATTTTTAGTTGAGACGGGGTTTCTCCATGTTGGTCAGGCTGGTCTCGAACTCC

18840 CAACCTTAGGTGATCTGCCCACCTTGGCCTCCCAAAGTGCTAGGATTACAGGTGTGAGCC

<-- AluSp

18900 ACCGCACCCAGCTCCGGTTTTTTTCTGTTTCTGAATTTTCCTATGTGTGCTGCATGGAAC

18960 CATTATAATTAATTTTAAAAAGCAAATATATTTCATTTGTCTCTTGAAAACTTAAAACAA

19020 CTCTTTATAAGAATTTTACATGTGCAAGATGGTATACTATATAGTCATTTACAATAATGT

<----- M+19.0F ----

19080 TTTAAAAGAATATTCCATAATATGAGAAAATATTCATGCTATATTTAGTGGAAGGAATAG

19140 GTTATGTAAAATATACTGTTTTTGTTTGTTTGTTTGTTTGAGATGGAGTTTTGCTCTTGT

19200 TGCCCAGGCTGGAGTGCAATGGTGTCATCTCGGCTCTCTGCAACCTCTGCTTCCCAGGTT

end of MEID-

19260 CAAGCGATTCTTCTGCCTCAGCCTCCTGAGTAGCTGGGATTACAGGCATGCACTACCACA

19320 CCTGGCTAATGTTTTGTATTTAGTAGAGATGGGGTTTCACCATATTGGTCAGGCTGGTCT

19380 CGAAGTCCTGACCTCAGGTGATCCACCCACCTCAGCCTCCCTAAGTGCTGGGATTGCAGG

------ M+19.4R --->

<- AluSq

19440 CATAATCCACCACACTTGGCCAATATACCATAATTTTTAAAAGGGCATTTACAGAAAGAC

<------ M+19.4F ----

M+19.5G/T

19500 TATCAGTAAGTCTGGTATAATACATATAAACTGTGGGGTTACCAGGAATGCATATCTGCT

19560 TCTTTATACTTTTCTGTATTTTCCAGATTTTTAATTATGAATATGAATATGAGTATGAAG

M+19.6G/A

19620 CTATAATAAGAAAAGTTATTTGAAAGTCACATTATCAAATTGTTCAGGTTATCATGGCCA

AluJb -->

19680 GGCAGGGTGGCTCATGCCTGTAATCCCAACACTTTTCGAGGCCGAGGTGGGCAAATCGCT

19740 TGAGCCCAGGGGCTCGATACCAGCCTGAGCAACATGGCAAAACCTTGTCTCTACAAAAAC

19800 TATAAAAATTAGCCAGATATGATGGTGCACACCTGTGATTCCAGCTACTAGGGAGGCTGC

19860 AGTGGGAGGATTGCTTGAGCCCAGGAGGCAGAGTTTGCAGTGAGTCATGATTTCACCACT

M+19.9C/A M+19.9aG/A M+20.0T/A

19920 GCACTCCAGCCTGGGCAAAAGAGCAGGACCCTGTCTCCAGAAAGAAAAAAAAAAGTGTCA

A A A

------

M+20.0aG/C

19980 AGTTGAGAGACAATGGTTATTTTTTATTTTTGAGATGGAGTCTCGCTCTGTCACTCAGGC

-- M+20.0R ----> C

M+20.1C/T

20040 TGGAGTGCAGTGGCACCATCTCGGCTCACTGCAACCTCCATCTCCCGGGTTCAAGTGATT

M+20.2T/C

20100 CTTCTGCTTCAGCCTCCCGAGTAGCTGGGACTTCAGGCACGAGCCACCTCGTCCGGGTAA

----- M+20.1R -----> C

20160 TTTTTGTATTTTTAGTAGAGACGGGGTTTCACCATATTGGCCAGGCTGGTCTCAAACTCC

M+20.3T/C

20220 TAGACCTCATGATCCGCCCACCTCGGCCTCCCAAAGTGCTGGGATTACAGGTGTGAGCCA

<-- AluSg

20280 TTGCGCCTGGCCAACAATGATTATTTTTAATTTTATTCCATGGTTTTCTATATTTTCCAA

20340 ATTCTTCTCAATAACATAAAAATGATTTCATATTGTATTAATTACTACAATGCAACATTG

M+20.4A/G

20400 TAAGGTCGGGGGACGCTGATGGTAGTCTACCTCCTGATCCTCTAGTATGCAGTATTTCAC

20460 CCAGGGTTTTCACAAGCAGTTTCTCATTTGGTCCTCAGAGGACCCTATACCTAGGTGAGG

20520 ATGGCGGTGCTGCTTCTGAGAAGTCGCTGCCTCCCCTTCTCCCTTTAGCCTCCCTGGCAA

20580 AATAAGACACTTCGATTGCGGGGCCACAGTCAGTTCTGACTCTGATATCTTACGACACCT

20640 ATCAGGGATCAGCCTGGACCTGTTACCTGAGCGGGGTGTGGCCTCCTTTCCTCTGCGCTT

M+20.7G/A

20700 TCCCCACACCTGAAACTCCTGATCATTCAGCCCCTTACCTCTCCCAAGCTTTCAGCACGA

------ M+20.7R ----> A

M+20.8T/C

20760 GCTCTCCTTCTTAGCCTTCTAAATAAATAAACAACACCTGCACAGAACACTGCCATTTTC

C <------ M+20.8F ----

20820 TGTAAGCTTTTCTTCCCCTTTAAAAATTGCAGTAAAATATACATAAGACAAAATGTATCA

M+20.9T/C

20880 TTTAAATCATTTTAAGTGTACAATTCAGTGGGGTGATATACATAAGGCAAAATGTATTAT

20940 TTAAATCATTTTAAGTGTAAAATCCAGTGCCTTTAAGTCCCTTCACGATGTCGTTGCAAC

21000 TGTCACCACCATCCAGCTCCGGAACTTCTTAATCATCCGTGGGTAAGCTTTTGAAGCTTT

21060 TGAATCCATAGTCTCATAACATTTTATTGCCGTCCTCATCGTCAGGTGAGGAAACTGAGG

----- M+21.1R ----->

21120 CTTTCTTCCTTACCTTGCTTTTGTGTTTTCTCTTTAACACTTGCACTCTGGCTTTTGCCC

M+21.2G/A M+21.2aG/A

21180 GTGGCTGTCCTGGAACTGACTCCCTTCAGGCTGTCAAAGGCCTCCTGGGGGCTGAGTTTC

A A

21240 ATGGGCTGCTTCCTGGTCTTGTCTTGTTTCTGGTCTGCAGCATTTGACAATCTTGTTTTC

approximate centre of hotspot MSTM1a

21300 CAATCTCTCTTAGAAATTATCTCCTCCCCAGGTTTCCATAATACTCTCTGTCTTGAGTTT

------- M+21.3R --->

M+21.4T/G

21360 CCTACTACTAATTCTTGGGTGTTTTCTTGTCCTTTTCTTTTCATGTTTTTCTGTTTGATT

21420 GTTTTGTTTCTTTTTGTTGTTTTGAGACGGAGTCTCGCTCTGTTTCCTAGGCTGGACAGC

<-- AluYc M+21.5T/C

21480 AGTTGCTTTATCCTAGAACTTATGATGTAGCTGCCTGTGTGCCCATCTGTCTCCACAACA

M+21.5aG/C M+21.5bA/G M+21.6G/C

21540 GAGCAAGGTCCTGGAAGCAGAGGTCGGGGGCGTGGGGGAGGTCTTGCTTGTCCTCTTTAT

C G C

21600 GTCTCAGTGCTTAGTGTACCTTATATTTGGACAATGAATAAATAAATGTGCGCTGCTCTA

21660 GAAAAGAGATCATTGTCTCAATGGAGTGAAAATCAGTAAGGGGTAGGTCTCGGCTCACTG

21720 CAACCTCCACCTCCCTGGTTCAAGTAATTCTCCTGCCTCAGTCTCCCGAGTAGCTGGGAT

21780 TACAAGCGCTCACCAACCCGCCAGGCTAAATTTTTGTATTTTTAGTAAGAGATGGGGTTT

M+21.9G/C

21840 CACCACATTGGCCAGGCTGGCCTTGAACTCCTGACCTCAGTTGATCTGCGGGCCTCGGCC

<-- AluSq M+21.9aC/T

21900 TCCCAAAGTGCTGGGATTACAGGCGTAAGCCACTGTGCCTGGCCCCTTTTCATGTTTTTA

M+22.0G/A

21960 TGTTTTGAGACGGAGTCTCGCTCTGTCACCCAGGCTGGAGTGCAATGGCGTGATCTCGGC

M+22.1T/C

22020 TCACTGCAACCTCCACCTCCCTGGCTCAAGCGATTTTCCTGCCTCAGCCTCTCAAGTAGC

M+22.1aT/G

22080 TGGGATTACAGGCGTGAGCTACCACCCGGCCTCTTTTCATGTTTTTAAATTAGTCTCCCC

<-- AluSx

22140 TTTTTATTTTATTTTATTTTTTAGATAGAGACAGGGTCTCGCTATGTTGCCCAGGCTGGT

22200 CTCGAACTCCTGGACTCAAGCAGGTTCTTTTCTTCAGGCTTCTCCTTCTCCTGCCTCAGG

M+22.3G/C

22260 AACTCATCCTCACTCCCTGCAACGTTTCAATAAGCACTTGCCTGGTTTGCCTGCCTCTGG

22320 CCTTGCTAATTAGACAACTACGATCTTTCTACCAGGAAAGTGTGATCCTGCCCTCAAGTC

22380 TACAAGGGCGGCCTGAGCTGACATGATAACATCTAACCTCTTTAGTTAGATATAGGATGT

22440 CCCTTGTCATCTGGCCCCTGGTGACCTCTAACAATATCCCCATCCCACTCCACCCCTTTA

22500 CAGTCTGCAGTAGAACCGTCTGCAGTCCCAGTGCTGGAAGCCCAGGCTGCCTCATGCCTC

22560 CCTGTCTCTGCATACATGGTCGCTTTATCCTAGAACATATGATGTAGTTGCCCGTGTGCC

<--- M+22.6F -

22620 CATCTGTCTCCACAACAGAGCAAGGTCCTGGAAGCAGGGGTAGGGGCGTCGGGGAGGTCT

----

22680 TGCTTGTCCTCTTTATGTCTCAGTGCTTAGTGTACCTTATATTTGGACAATGAATAAATA

M+22.8G/A

22740 AATGTGCGCTGCTCTAGAAAAGAGATCATTGTCTCGATGGAGTGAAAATCAGTAAGGGGC

22800 AGAGTAAGGACTGGACATCAGGTCTTGGAAAGTTCTGACCCTTCCCACTATGTAAACATC

22860 CTTTCTACTGAGGGACCTCACGGGGTGACAAAGCCTTAGAGGAAATGTACGCAGTCTCTG

22920 CATGGTCCTAAGAAAATAAAGGAAATAAAGTAAGTGTTGTAATCCTGGACTGGAGTAGAA

22980 AGACTTCTTAGGGGGAGGCATTTTAAGGAGGGTGGAGAGGGGGATGCTTCCCGCCTCCGG

23040 ATCACAGTCTACGAGAGCTTGCTGCTTTAGATGAGCCCACACCAGACCGAGACACAGGCA

23100 GAGCGGTGCGGCTGAAAGACATCTCTGCATCAGAAAACTTGAGTCCTGGTTTTTTCTACA

23160 TCTGCCGCTGACTAGCAGATCTCAGAAGGCCCAGCAGCCTTCAGGTGTAAAACAAAGGAG

<----- M+23.2F -----

23220 TATTTTCCATCTCTTTCAACCCGAAAATCCAGAAAGTGGGGACATCTGTGTTTGAAGATT

very approximate centre of hotspot MSTM1b

23280 GTTCAACATTTTTCAGATTAAACTGATCCACATTTTCCAAGGTATCAAAGTGGTGGCTGC

23340 ATCCTCTCATGGTGCTGGGAATCACAGACTTCTCCCCTCACCCTTGATTGTGACCTGATT

23400 CTAGAAGACGGTTGCTGATAGAAATGTCCAAGTTATTCAAGGGGCTTCTCTAGAGGAAAC

23460 AACTTCCATTTCACTCTTGATTCTCTAGAGGAAATATAACTTTCGTTTCACTCTTGATTC

23520 TCGAGAGGAAACAACTTCTGTTTCACTCTTGATTTTCACTATTTTCACGTTACGGGTTGA

23580 GATAAATGGCCTTAGATTTGACTCATCGAGGAGAGAGCGATTCTGCCTAGAGTTCTTTGA

23640 AAGCCGGCTGTACTGAGTGAGATCCTAGGTCACTGCAGAGAAGGAAAGGGAAGAGAAGTG

------ M+23.7R ---->

M+23.8G/T

23700 GGGAGGGAGAGGGGAACAGAGAGGGGCACGGAGAGGGACAGGGAGATTGGTTTCCTTTGA

23760 CAAACCCAGCTGGTTTCCTCGGTAGTTGTGTGTGGTTTCCACCAAACCCACCTATCACTT

<----- M+23.8F -----

23820 AGTTAGGACTGCTAATTAGGGGGCAGAGATGAGGACTGCTGTCTGTAGTCGTAAAGATGG

------ M+23.8R ---->

M+23.9G/A ! M+23.9aC/T

23880 TTACTAAGCAGGAGGCTGAGCTGGTGGTTGCAGCTGACACTGGAAATTCACCCAGCTTCG

A T

M+24.0G/A

23940 CCCCCCGGGAGATGTGCCACCCCTACATCGTAGGCAGCTGTGGGCCACAGGCATTTCGTT

24000 CTCCAAAATCCTACATTCATCTTACTTCATTTAATGTTTGCAGCCACATAAGAAGTAGAA

24060 AACATAACTTGATTTCCAGATTAGAAGACTGAAGTTTGGACAGAAAAAATAACTTGCCCA

24120 GTGTCACCCAGCGGGCACACGGAGGAGCTGGGATTCAACATCAATGACTCCAGGACCATG

24180 GTCTGTCTCCACGAGACTAGTCTACCCACCTCGATTCTCTGCCTGGTAGGCCTTCCCCAC

24240 TTTTCCACCTGCTAAATCAATCACACCTGGTTGCATCTCTCCTTCTTTCCTCCCCTAACC

24300 CAAGACTCTTTTTTGTTGTTGTTGTTTTGGAGATGGAGTTTGCTGTTGTTGCCCAGGCTG

24360 GAGTGCAGCGGCACGACCTCGGCTCACCACAGCCTCTGCCTCCCGGGTTCAAGCGATTCT

M+24.4G/A

24420 CCTGCCTCAGCCTCCCGAGTAGCTGGGATTACAGGCACGCGCCACCATGCCCAGCTAATT

24480 TTTGTATTATTAGTAGAGATGGGGTTTCACCATGTTGCCCAGGGTGGTCTTGAACTCCTG

24540 ACCTCAGGTGATCCACCCGCCTCAGCCTCCCAAAATGCTGGGATTACAGGCGTGAGCCAC

<-- AluSq

24600 CATGCCCGGCCATATCCCATGACTCTCTAAAGCACTCTGTGGTTGTTTCTGGGTTATTTT

24660 CACTTCTCCAATTAGGAGGTAAGTTTTTTGGGGTCAAAGAGCATGTTTTCGACTTTGTTT

24720 TCATCCTATCCCAAATTGCCTGGTACCAAGCTTGGTAGCTGATGAGCCAACAGGGAACCC

24780 ACGAATGACATTGTATTAGAAGACCACAGGCTTTGGGCTCAAGGAATGACCCTTCCCTTT

24840 TACAGTCCTGTCCACACCTCAACAGCCCTCTCGTAGCTCGGTGGATCTCAGCTGAATGTC

24900 AATGAGCCAGAGCTTCCCCTGACCACCCAAGCCCAAGTGTTGTCCCTGGCTATTCCTCCT

24960 CGTAGCATCTCTTTTTCCTCTTCATCGGACTTACTACAACGTGTACTCATAGGCTCATTT

M+25.0G/T

25020 GAGTATCTACCTTATTTTCTCCACTAAAATGTGAACCCCAAGAGGCCAGGGACCATGGGC

25080 ATTTTGACTCAAAACATATTCTTTGAATGACTTTAACAGAAACTTCCATCAACTTCTCAA

25140 AGGGCCAACCACATACGCAGTGAAGAGGGTTTCAAATGATGAATCAGGGACTTTTCCCTG

------ M+25.1R ---->

25200 TGTTCAGGCGTGAACCCCGACTCACCATGGGGTCGTATCCACATGCTCTCTCTTGACCTC

<----- M+25.2F -----

25260 AGTTCTTTACTTGCAAAGTAAGGATCATGGTTCTAGTCCCATTTACTCTCATAGGCTCTT

25320 GCCTGGAGAAAGTGAAATCATTTTAGCCTTGCTGTGTTGTTAAAGCCAAGGCCTAATGCC

25380 AACGTGACTAGTTATAAGCCCCTTGAGGAGGGGCTCATGTCTGACAAACACTCTGTCTCT

25440 CTGTCCCTCTCAACATAATTTTTGTGAACAGGCCAAGTAGATAAACAACTCAAAAAAATA

M+25.5C/T

25500 AAAATATACAAAATGCATACAGTGACAACGTTCCCTTGCTCCTCTGTCCACACCTCCCCA

M+25.6T/A

25560 GGTCCCACCCTTAACCATTACTATTGGTTTTATTCATAGCATTCCAGAGTTTATTTTTTT

25620 TTTTTATTTTATTTTACTTTATTTTCTGAGATGGAGTCTTGCTCTGTTGCCCAGGCTGGA

25680 GTGCAGTGGCCCTATCTCGGCTCACTGCAAACTCTGCCTCCCGGATTCCAGCAATTCTCC

25740 TGCCTAAGCCTGTCGAGTAGCTGGGACTACAGGCGCCCGCCACTATGCCTGGCTAATTTT

25800 TGTATTTTTAGTAGAGACGGGGTTTTGCCACGTTAGCCAGACTGGTCTCGAACTCCTGAC

25860 CTTGGGTGATCCACCCGCCTCGGCCTCCCAAACTGCTGGGATTACAGACGTGAGCCACTG

<-- AluSx

25920 CGCCTGGCTGCCATTTTAAAATATACAATTAAACCATTATGGACCACAGTCCTCAGTGTG

25980 TGATCAAATACTCAGTATTATTCACTCTTTCTATTTTCCAGAGTTTCTATATCTGCCTAC

26040 AAGTAACCATGAAAGCACTTCCCCTACAGGATCATGTCTTACCCTTGCAAGCTTTCCAAC

26100 TGTCTTGCTCCATGCCCAACACCAGGTAAATCTTTAGTAAATTCAGTACATTTAGTAAAT

------ M+26.1R --->

26160 CTGTTGGTGGATTTGATTAACTAATGATCTTGAAACCAACACATTGGACAAGCAACAAGG

26220 TGAGTTTGCAATGTGTGTTACAGACGGATGAAAGCACACGCTGAACAGGGCCTACTCCAG

<----- M+26.3F ----

26280 TGAACCATCATCTGCCTGCATCTTTCCTGTTCCAGTCCAAGACCAATCCGGATACTTGGG

26340 CCTTGTTTTGTTTTGCTCTTCCTGGGAAGTGTCAGTTCATTGGTCGTTACAAGGATAATA

26400 GGAGTTACTTCCTGACTGCATGAAAAGTACATAGAACAGAGCCTGGCACAGAGAGAGAAG

26460 CCAATGAGCAGCAGGAATGATGATCACAGGCAATCTTCCCTTCCGCCACCACTCACCTCA

26520 GATGACCTGGTGAGCCTTGTGTCACAGGCTGGGTACTTCCCCCGGAATTCACATGTTGAA

26580 GCTCTAACCCGCAGTACCCAGAATGTGACTGTATTTGGAGAGAGGGCCTTCTCTCCAAAT

26640 AGAAGGAGGTAATTAAGGTAAAATGAGGCCATTAGTGTGGGTCCTAATCGGATATGACTG

26700 GTCCTGATGAGAAGTGGAGATTAGGATACTGACACACACAGAGGGAAGCCCATGTGAGGA

26760 CCCAGGGGAGGGAGGCTGTCTGTGACCAAGGAGAGTGGCATCAGGAGAAACCAGCCCTGC

----- M+26.8R ----->

26820 CAACGCCTTGGCCTCCAACTTTCAGCTTCCAGAACTGGAGATTTGTGTCATTCAAGCCTC

26880 CCAGTCTGTGGCACTTTGTCATGGCAGCTCAAGCCGACTAGCACACCTTGCCTAGCCCTG

26940 CTTTTCTCAAATATGTTCAACTAGAGAAGTTGTCTTGATTGTTTAGAGCCAAGCCCTGTG

27000 CTGCTACAAGGGCATAGGCTGAACCAACCACCTGTCAAGGAGTTTCCATGCAGAAGGGGG

27060 TGAAGGAGGCTTCACCCTAAGGTGAGCCCCTTGACCCTCTCCCCAGGAATTCTCCAGCTA

27120 TGCCTGGGGATGGAAGCTGCCTTCCTGACTACTCTTCTGTTGTTGTTAAGCGCTGGGGTC

27180 TCACCCTGTCACCCAGGTTGGAGTGCAATGGTACCATTACAGCTCACTGCAGCCTCGAAT

27240 TCCTGAGCTCAAGTGATCCTCCTGCCTAAGCCTCCTGATTAACTGGGACTGGAGGTGCAC

M+27.3T/C

27300 ATTACCATGCTAGCTAATTTTTTTGATCTTTTGCAGAGATGAAGGTCTTGCTATGTTGCC

27360 CAGGATGGTATCAGATTCCCGACCTCAAGCAATCCTCCCACCTCAGCCTCACAAAGTGCT

<-- AluJo

27420 GGGATTACAGGTATGAGCCACAGACCTGTTCCCCTGGCAGGTCTTTGAAAATGCACGCAG

27480 GGCTGCAGCAGCCACAGCCCTGCCAGAGAGAGAAGCCCCCATTTGGGGGTTGTGGGGAAG

----- M+27.5R --->

M+27.5G/C

27540 CAGGCATCTGCCAGAGATTCCACGTGGTTCTGGCACGTCTCAGGCCAGCCTGGGCTTTAA

27600 TTCCTTGGCTAACCCTCCTTCCTTTCTTGCTGAAGTAAATGAGATATGGTTTATGACGTT

27660 TGCAGCTCAGGGGGTCTTGACTAATATAGTCTCTATGGAGTCAGATCCTGATGTTCAGCT

27720 ACTCTTGGTCAATGGTTCCTGCCGGGGCTCTGGCCTCTCACTCCTGTAGTAGTGCAGGGC

27780 ACTGCAGGGCCACTCATGTCCTCTCTCACCTCTGGGCCTCTGGGACAAGCCTCTAAGCAG

27840 AGTGGATGTCTATGCTGAGCAGCATCTGCTGACACCAACCAGACCACTTCTTCTGATGAT

27900 GGTGACAGTTGCTCAGGTTCTCACCAAGAGCCTGGGGCTCCCTCCTGTGGGCTTCCCTGG

27960 CACAGTTTGCCGATGGTTATTTAAGCACATATCACAAGGGTGGGTGTGTGTCTGTCTTAG

AluJo -->

28020 GTTATGATCTGAGAGACCAAAATAGACACCCCTGGCCAGGTGTGATGGCTCATGCCTGTA

28080 ATCCCAGCACTTTGGGAAGCCAAGGTGAGAGCATCCCTTGAGCCTAGGAATTCAAGACCA

28140 GCCTGAGCAACATAGGGAGACCACACACACACACACACACACACACACACACACGCACAC

M+28.2-/+

28200 ACACACACACACAAGCCAAATGTGATGGTGCACACCTCTAGTCTGATGTAGGCTGATGTA

TCCCAGCTACYTGGGAG

28260 GGAGGATCACTTGAACCCAGGAGGTCGAAGCTGCAGTGAGCCATGATTGTGCCACTGCAG

28320 TCCAGCATGGGTGACAGGGCAAGACCCTGTCTCAAAAGCAAAACAATACAAAACAAAACA

28380 AAACACCAAAATAGACACTCCTTTATCAACTAAGACAGATCCTAAGGTTAAGGAGCCAAA

28440 AGTTATTAACAGGTCGAGGGTTCAAAGTTTGGCTGGCATGGCAACTTCTTAAATTCCTAC

28500 AGGAAAAACCACACTCTTGCTAAACTCCCTAACAACAGGAGCTAGCAAGCAAATTATCCT

28560 AACTCTGATTTACAACCCAGACCACTAAAACTTTCATTGGACAGAGGACCATCTTACAAA

M+28.6G/C

28620 CGCTCTTTCCTGATAAGCAACTGCACACCTCCAGCCAGTTCCAATGTGACTTAGAGACTG

28680 CACACAAACTGTCTGTGTCCTCTAGGTTACCTTTGACATAAAGAGCCAAATTCCACCTCA

28740 TTTTAATCTAGGCCCCCCACAAAGTGAACATGGTAAACATATGTGTTTACCTATTGCACA

28800 CTGAGTGCCCCTCATAAATATGTATTGATTTTGCCCTAAACTTGCTGAATATGCGGACTC

28860 TACTTTGTAACACAGACTCTACCGTGTAACACCCATCCTGCCCTCTCCCTCTTTGAAGAG

------ M+28.9R ---->

28920 CAAGCACTTTCAGTCCAAGCTGGAGACCATCTCTTCCTGGTTTGCAAACTAATATCAACC

<----- M+28.9F -----

<----- M+28.9F2 -----

28980 AACAAAGCTCTCCTTTCTTTCTTTTTCTTTCTTTTTTTGGATGCAGTCTTTCTCTTGTCG

M+29.1T/C

29040 CCCAGGCTGGAGTGTAGTGGCTCAATCTTGGCTCACTGCAACCTCCACCTCCCAGGTTCA

M+29.2C/T

29100 AGCAATTCTCCTGCCTCAGCCTCCCAAGTAGCTGGGACTACAGGTGCCTGCCACCATGCC

29160 TGGCTAAGTTTTGTATTTTTAGGAGAGACGGGGTTTCGTCACGTTGGCCAGGCTGGTCTC

29220 CAATTCCTGACCTCAGGTGGTCTGCGGGCCTTAGCCTCCCAAAGCGCTGGGATTGCAGGC

<-- AluSq

29280 GTGAGCCACCGCGCCCAGCCCAAAGCTCTCCTTTCTACCGCCGAGCCACCCTGGTAGTCT

29340 TTTGCATGGCAGACTTTTCGAGACCTAGGCCTGTGTCATAATCATCTCCATAGTCTCAGC

29400 ACTTGCCACAGTGCCCAGCACGTGTGCTGCTTTCAACCAGCTGGCGAGGTCTATGTGCTC

29460 CCAGCCCATGGTGGCTCGTCAGTCCCTCAGCTCCCAGGAGTCCTGTGGGTGCTCACAGAA

29520 ATGCCAACCACTGTCCAACATCAATTTTTTTTTTTTGAGGTGGAGTCTCTCTCTGTCGCC

29580 CAGGCTGGAGTGCAGTGGCATGATCTCAGCTCACTGCAACCTCAGCCTCCTGGGTTCAGC

29640 CTCCTGAGTAGCTGGGATTACAGGCATGCACCACCACACTCGGCCAATTTTTTGTATTTT

29700 TAGTAGAGACAGGGTTTTGCCAGTTGGCCAAGCTGGTCTCGAATCCTGACCTCAAGTAAT

<-- AluSx

29760 CCGCTGGCCTCGGCCTCCCAAAATGCAGGGATTACAGGTGTGAGCCACCACGCTCGGCCA

29820 GCATTGACTCTTTTACAGCTTGCTGTTGTGGAGTCAAGAAGGATCCAGACCAAGATCCAA

29880 CCTTCACAGCAGGTCAGAGTTAAAATGTCATTACTCGAGCAGCACTTACTGGAGCAGAAC

29940 AGAACTGGCTGCTCACTGGCCCTTGGCCTTGCTGCCCTTGCTGCGGGGGGACCAGAGTCC

30000 AGAGCCTGGCTGCATATTGAAGGACACCAGCCAGAAAGGGCAGCAGGGGGAACTGCAGTT

M+30.1G/C

30060 CGTAAGGTCATCAGCTCCAGGGGCCACTACTATGGCCGTGGAATTGGCTGTTGTCATCCC

- M+30.1R G-------->

M+30.2C/T

30120 AGGTTGGCGGAAGTGGTGGGTCCTCACTGGGCTTTTTGGGCCACGTTGCCCTGTGGCTCA

T <- M+30.2F

30180 GAGCTAGACATGAGGCTTTCTGGGCCAGCTCTGACCTCAGTTAGCTGTGTGGCTTTAGGG

---------

30240 AAGGTCCCTAACCCTGAGCTTCCTTTAATCGTCTGTTAGACAGAGAGAACAATAATTATA

----- M+30.3R ----->

30300 CATTAATAAAGACATGTTTACGGATGAACAAAATACTGTGTGTTAAAGTGTTCAATTCTA

30360 ACACCTTAAAAATGGTTGTTTTTGGTTCGTTTGCTTGTTTGGTTGGCTTAACTCCAATCT

30420 GTGGTCCTCCTCCCCCTCTGCCTCTTATGGTCTGACCTTCTTAGGGTTCTCCAAAACCTG

M+30.5G/A

30480 CTTGCTCTCAGTCCTCGCAGCTCACACAGGCTATGCTATCTGACCCCCTACTTTTCTGTG

30540 TACCAAATCTTTTTACATTCCTAGTTCCTACTTGTCATTTGAGCCCTCCCTAATTGTATA

30600 CTTCCTTCTTTCCATCTTAATCCTGTGATTCTCAGTCCCGGAGCTGGGAAATGTTGCACC

30660 TAGTAAGTGACTGCTCATTTCAGGGCCATGCGTGGCTGAGTCACTTGTTATTTTTGTTTT

M+30.8G/A

30720 TTGTTTGTTTGTTTGTTTGTTTGTTTTGAGACGGAGTCTCGCTCCGTTGCCCAGGCTGCA

------ M+30.7R --->A

30780 GTGCAGTGGCGGGATCTCGTCTCACTGCAACCTCTGCCTCCCAGGTTCAAGCGATTCTCC

30840 TGCCTTAGCCTCCTAAGTAGCTGGGATTACCGGCACACACCACCATGCCTGGCTAATTTT

30900 TGTATTTTTAGTAGAGACGGGGTTCCACCATGTTGGCCAGGATGGTCTCCAACTACTGAC

30960 CTCAAGTGATCTAACCACTTCGGCCTCCCAAAGTGCTGGGATTACAGATGTAAGCCACTA

31020 TGCCCGGCCTAATTTTTGTATTTTTAGTAGAGATAGGGTTCGCTATGTTGGCCAGGCTGG

M+31.1G/T

31080 GCTCGAACTTCTGACCTCAGGTGATCCGCCCACCTTGGCCTCCCAAAGTGCTGGCATTAC

<-- AluSq

31140 AGGCCTGAGCCACTGTGCCCAGCCCCAAGTTAGTTGTTATAAGGGGCAGAGAGATAAAGA

31200 GTGAGACAGACCAGCATCTATCTGTCACCAATAATGTAAGAACAGCCCAAGGTCTTCTGT

31260 CACCACCGTTAAACTGTCAGGATCAGCACCATTCGTGGCTCCCAATTGGTGGGCTCTCAT

31320 GTTCTAGATGTAGGGCTAGGCACTTACATGCATTATTTTATTTCATTTTCGCAGTAGCTC

31380 TGTGAGGTTGATGGCCTAGTCTGGACAGGAAGAGCGGTGGGTACTGACAAGGCTGTGCTT

------ M+31.4R ---->

31440 ACAGTACATCAGTGAAGCACAGCACTTGTGCATCCCAGCAAAGCTCAGAGCGACCCATTT

31500 CTCACCTCAGTAGCTGGCATCCGCCTGCCAGTGGCCTGCCTCATTCTCTGGGGTCCCAGC

31560 CCGCTCCAGAAACTCACCCAGCTCGCTGACAGGGGACTGTGCAGGCTGCTGCTGTAACCT

31620 GGTGGTGGGCTGTCATCAGACGGCCATAGAGGATCGCCCTGAGGCTTGGTTGTGGAGGTT

31680 GTCAAAGCAGAAGGCTGGCAATATTCCCATGGCCCAGAACGTGCTGAGGCAGCATATGTG

31740 AGTCAGGCCATGGCTGCTGCAGCCACAGTGGGGCTTTGTGCTGTGATCGTGTGCAGAGCA

----- M+31.8R ---->

31800 GAGCAGCCACTCAGCCATCCACTGACTCTCCAAATTGCTTCTGAGCACCTATAATTCCAG

31860 TTCTCCTGGGAAAAGCCCTGCAAGACCCGGGCTTTCCCCTACCCTGTTCTGCTGATTCCT

M+31.9A/G M+32.0C/G

31920 TTTGGTTGATTTCCCAGTATGAGATCCAGCATTATTCCTTTTGAAATTGCAATCCCTGCT

G G

31980 GTTTTCCCACATTGAGAGCACAACTAAGAAGCACTTTCTTAAGAATCTGCTTCCAGGTGC

M+32.1T/C

32040 TCTTGGACCAAGTTTAAGTTCTCTGTCTACTCTAGTAGGGTCCGTCTATTCCCAGGGCAT

M+32.1aC/T

32100 CTGTCTGAAGCGGGGCCTCTGCTGGCCAAATCCTACTAGCCAAGACCTGGATCTCCCAGA

32160 GCTCAGAAAGCTCCCACTAGCAGGGCCCCTTGGCTTGCCTTCCTGCCTCCTTTCTCTCCC

approximate centre of hotspot MSTM2

32220 TTTGTCCCCTAGTGTCCAGATGAGAAGACACAGGATGGCTCTCGTCCCAAGAAGGCCTTC

M+32.3C/T M+32.3aG/A

32280 GCTTGTGCTGTGGGCACAGAGGTCTTTCTCCCCTCTCTGAGCACAAAGCAGTCACTGTGC

----- M+32.3R -----> T A

32340 TCTGCCGAGCAGAGGAAAAATGCAAATGGTGCTCTGGGTGTGGCCAAGTTCCTTGGGCCC

32400 CAAGTGCTGGCCTGCATTCTTTATGGGGTAGCCTTTGTTTTCCCTTTCTGCAGGCTGTGC

32460 CTGAAATATGAAGATTACTTAAAACTCATACTATGCCAGGACACGGACACCACAATAAAC

32520 TGGGTAATGAGTGTCAACTCAAAGACTATTTAAGATTAGTTGCTGCACAAGAAAACTTGA

32580 AATGTTCTGAAAGCTTATGAACCATAAATGAAAGAAAAGTTCATTCATCACAATGTCCTC

32640 AAGCTTGAAAACAACCGTAAGAATCTACAAGGCTAACAACGAGTTGCAAAGCTGAAACAA

32700 ACTCTCCTGAACCTTAATAACAAAAACAAGGTGTGATCAATTGTGCAAGAGGAAAGAAGT

M+32.8C/T

32760 ATCTTCCTATTCCCTCTACGGAAAGATATTATTACAGAATTATTCTTTCTGTTGTCATTT

32820 GTTTTATTTTTTATTTTTATTTTTATTTTTAGAGACAGGGTCTCATTTGTTTGCCCAGGC

M+32.9G/A M+32.9aA/G

32880 TGGAGTGCCGTGGCATGATTATAGCTCACTATGGCCTCGAACTCATGGGCTGGAGTGATC

A G <-- AluJo

32940 CTCCAACCTCAGCCTCCCAAGTAGCTAGGACTACAGGTGTGCAGAATCATTCTTATATTA

33000 AGAGGGGTATACAGCCAAAAAAAATGCAGAGGAACCTCGGGCAATTACTAAGCAAAAACA

33060 TTGCATTATTCTTCTGAGTTTTGTGATATGTGTAGTATTGGTCAGCGTCTGAAACTTTGT

33120 AATTTGTTCCAAATAAATTTCTTGTTCTAAATAAATATTTACTTTAGTATTAAATTTTGC

M+33.2G/A

33180 ATATGTAATTTTATTTTTTCTTTCCTTAAAGAGGATCTCTAGTATTGAAGAAGGTTGCAG

33240 GCCCCACAAAAACTGGATCTGGCCTGGCCTCTGGAACTGCTTTCTCAGCACTGCTTTCAA

33300 CGTGTCCCTCACCTTCATTCCTTTTGCCCTGCCCTGGGGCCATAGGTAAAGCCTTTCTTG

33360 CATAGTTCACCGAAGCCTGGAGATTTCAATTCTATCAATAGCTATACATGTTGTGTGCCC

33420 AGGGACACCCATAATAGCTAATTTTCCCTGCAGTGCGTGAATGTTATACTCCTGAAAGCA

33480 AGATCTGGTCAGTTCTCAGTCCCTTTGATGTAATGAAGTTCTGTGGGTACAACCAGCCAC

33540 CTCTTTCTGCATGAGCTCCTTGAAACACTGCCTTTTCTGGAGATGAAAATGGGAACCAAT

33600 TAGGAAGAACACTGAACGTTATCAGGCAGCTTAAATGCCTTTGCAAGAACTCCTGGTAAG

<--- M+33.6F -

33660 CACTGGATCTAATTTTCCCCTCCGAAACTTGAGCAAACCACTCACTATGACTTTCCTGGA

------

33720 GCAGGAAATTATGTTGTTTTTTTTTTTTTGGGTGGGGGGAACAGAGTCTTGCTATGTCAC

33780 CCAGGCTGGAGTGCAATGGCTTGATCTCAGCTCACTGCAACATCCGCCTCCCGAGTTCAA

33840 ACGATTCTCCTGCCTCAGCCTCCTGAGTAGCTGGGATTACAGGTGCACACCACCACGCCT

33900 GGCTAATTTTTGTATTTTTAGTAGAGAGGGAGTTTCACCATTTTGGCCAGGCTGTTCTCA

33960 AACTAATGACCTCGTGATCCACCCACCTCGGCCTCCCAAAGTGCTGGGATTACAGGCGTG

<-- AluSg

34020 AGCCACCACGCCCGGCTGAGGTTATGATGTTAAGATGCTTCTTAGGATTCATTTATAGTA

34080 ACAATTTCATTCTGTTTCCAGGTGAATAGGAAATAGTCTATGTTCTTGACCTTTTAGACT

34140 AAATTTCCTTTTTTGTCACAGATCCACTTAATAATACCAAAGTTTTAATGAAATTATTGA

34200 ATCATTAAGAGAGCATTTCTGAGCAACTCTAGAAGGGCTACACCATCTGCCTGTTTGCTT

M+34.3C/A

34260 AGGTACTAGTTAAGGATTGTCCTCGATTTGGAGTTTATTATAAAGAATCCCACTGGAACT

34320 ACCTGCTTGAATTAAAATCTGATTTTTATCTTTTGACCGGAGGGATGAAAACAGTCTAAG

34380 ACAGATTTATGGCGATAGTTGCACAACTTGGTGAAGTTACTGAAAATCACTGACTTATAC

34440 ACTTTGAAATGAGTGAACTTTGATTTGATAATGTTTTTAAAAAGTCTGATATGCTTAATG

M+34.5T/A

34500 GTCCTTCAGTTTAGGAATCACAAACACGAGAGCATAAAATAGGCATAAAATTCACGTATA

M+34.6C/T

34560 TCTTAGAAAAAGTACAATTCGTTAGTTAAAATAGGAACTTTCAAAACACTCCTGGCTTTT

34620 ACACAAGAATAATCTTAGCTTGTAAAACCCTACTTATCACGTATGCTATCTTACCTACTC

34680 CTTGAATCTCAGCATTCCTAAAACCTTTGAAACTCTTAGCATTCAAATTTTAAGATTGTG

34740 ACTTAAACCAAAAAACTCACAAAAAACGTAGACTCTGTCCTGAGTGGCTAAGAACAAAAA

34800 CTCCAGCCAGTGAATCAGTTGTTCATTCAGTTATGAATCCAACACCTAATATGTGCTGAT

34860 CTTGGAAGTGAAGAGATAACTCTGTGTTTCTATCACTTTAGGTTTGGTGAAGCAGGACTT

34920 GTCATTGCCTAGAGCAAACAAAAAGTCTTTTATGGGCAGAATTCAGAGACTAAGAGCCAC

34980 ATGACACTAAGTTTTCAAAGCTTGAATTTTTAGAATTCTACTGTAACTGCTGAGGTAGTT

35040 TCCTCTAACAATGTACAACTATGAATATAAATAAGTCCAGCCTGATGATGGGATTCTCTG

35100 CTATTAGGTCAAGGTTTCCATTTTTTAAGGGGCCTGCACTCCTTAGTTGACTGACATTCC

<---- M+35.1F ------

35160 TTCTGGCTAGAGTTGTTTTTTCTGGGGGCCTCTATTAATATTCTAGATTGAGCAGGCTAT

35220 GACTGGTTATATGGTTCCTAATGATAATTTATTTCTATAGCTGGAATCAGCAGAACCAAA

M+35.3A/G

35280 TGGTACAAAGTATTCCTTCCCAGGGAAATACTAGCACAGATTTGGTTGTCGAAACAAGCT

35340 ACTCGCCACCTTGGAAATTCTAGTCCTCTGAAGCAGAACACAGACAGATACGTTTTATTG

35400 GGCAGGAAGTGTGGGAGGGGTCTGTTCGCTCATTTCAAGTACACAAGTCATCGATTTTTA

M+35.5C/G

35460 GTAAATTCACCAAGCCTTGCAACTATCACCATAAATCTGTGTTAGACTGTTTTCATCCCT

M+35.5aA/G

35520 CCAGTCATAAAATACAAATCAGATCTTAATTCAAGCAGCTAGCCCCAGTGGGATTCTCTA

35580 TAATAAACTCTGGGAGGGGTATCCTGCATGCTGCTGTCAGCAGACTTGGAGGAGCTTCAC

M+35.7C/T

35640 ACTGGGGGTTCCTGGATTCCTGAGCAGTATAGAGGCAGGGTAGGAGGTTTGGAGCTGCAA

<----- M+35.7R -----

35700 GAGATGCCTGTTGGTAGCCTGATCTCAGAGACCAGCCAAGTTGCAGAACAGGAATTCTGT

M+35.8A/G M+35.8aT/C

35760 CTTTAGCTTGCCTTCTTTTCACTCCCTAAATATTTCAAAGGAAATAGAAAAGAATTCCTG

G C

35820 AGGACAGATAATAAAAAAGATAATCTCATGCAAATGTGATGTACATTTTCCAAAACGTGA

35880 ATTTTCAACTTTTTTTTTTTTTTTGAGATGGAGTCTCGCTCAGTCACCCAGGCTGAAGTG

35940 TAATCGTGCGATCTCGGCTCACTGCCACCTCCACCTCCAGGGTTCAAACGATTCTCCTGC

36000 CTCAGCCTCCCGAGTAGCTAGGACTGCAGGCACCCACCATCATGCCCAGGTGATTTTTGT

36060 ATTTTTGTAAAGACAGGTCTTTACAAAACAGACATGTTGGCCAGACTGGTCTTGAACTCT

36120 GGACCTCTGGTGATTCACCCGCCTTGGCCTCCAAAGTGCTGGGATTACAGGCATGAGCCA

<-- AluSq

36180 CCACGCCCGACCAATTTTCAACTTTTAACAACACGCATAAAATAATCTGGGAAGATCTGT

36240 AACAGTATGGAAAAGTATTTGTCCCCATCTGGACTTCCAGCACGGGCACTCCCTTTCTCC

<----- M+36.3F -----

36300 ACCTGGGAAATTCCCTACTTGAAGAGAATGAAGTGGAAGCTTCCACCATAGAAGCGGCAG

36360 ATGCCAGGGAGTCATGCTCCCAGCCACCCTTGCTAAGATGAGAGCACATGGTCTAGACTC

36420 TGCTAATCAAACGCCCCTGCTCCAGACTTTGAATTGGAAGAGTGTGACTTAAGGAAGCAT

36480 GGACTGCATAATCTACTCTAGAGACGGATTCATTTATCCAAAACCCTTTGTAACCTCTTC

36540 CCTTTGCCTGTCCCTACTATAGAGGCTGGATGTGCCAAATGAGTGCTTCCCTTATAGCTC

36600 TAGATGGCTTATGGCACACTTCTGGCCCAAAAGATGTAGGTGGAGGCCTGACTTGGGATT

36660 TTTTGGTAAAACCTTGTCCTCCTGACATAGGAGTCACTCTTTCTGTCTTCTTCCAATTTC

36720 TGCCTTGAATGCAAATGTGATGGCTGGAGCTAGAGCAGCCATCTTGCAACCACGAGAGGA

36780 CAACTCTGAAGATTAAAGCCAATATGCTAAGGATGATAGAGAAGAAAGACAGATAGGGCC

36840 AGGATCCCTCACAGATTTTTTAAATGGTTGAATCAATGCTTGCAACAACTGACATCCAGA

36900 TATGTAAGAAAGACAAACATTTACTATTAATCTATTATTAGACAGATTTTCTGTTACTTG

36960 CAACTTTCTTCTTGCCTAACTGATACAGGCAATTTCCAGTGTCCAGCACTAGTATTTCCT

37020 GTGGGGCAAACTACTAGTATCAGAGCCAGTGGTAGGGGCAGTGATATTATTCTAGAACCA

37080 GTCCTGCAGCATCACTTTGGGTATCATTCCTTCTTCTTAATCTCCAAGCTCCTCCAGCAC

37140 TCTTGGAGATTTTGTGAACCACATAATGTGCCTTTTAATGAATTCTTTTTCTGCTTAAAT

37200 TAACCAAATCTTACTTCTGTTGCTTGCAACCAAGAACTCTGGGAAATATAGAAATAGACA

37260 CCGGGAGTATTGGTAGCCACATACTCTCAGAGAATGGTGAGAATTTGAGCTTGGTTATCT

37320 GGTCTGGTTGAGCTGGAGGAAAATGAAAATTCAGATAGTGTTAAGACGGTTCATGGCATA

37380 AATTGTCATTTGTGGTCACTTGCGGTAAAGGTAACCCAGGACAATGAAGATTCCATTGAC

37440 ATTAAAGTTTTCAGAAACAGAGTGATGCTGCTAGACAGCAGTATGAGGGACACAAAGAAT

37500 TTAAGAGCTGTGGGGAAAAGTGGTTGATTCTAGCTTGAGAAGCAAATAGCAAGGGCTGAA

M+37.6A/C

37560 ATTCTAGTTCAAGGCACACAGTCTGAAAACCTAGGACTTTTGATGACTTTCAATGAAGAT

----- M+37.6R -------> C

37620 GCTAAAAGACTATTTTATCTTTTGCGACCATGGCCAAAAGGGAGAGCCTGTGCATTTCTG

37680 GTTGGTTTTCTTTATTTCTTTCTCTCTCTTTTCTTTTCTTTTCTGACAGAGTCTCACTCT

37740 GTTGCCCAGGCTGGAGTGCAGTGGCGCGATCTCGGCTCACTGCAAACTTCGCCTCCCGGG

37800 CTCAAGTGATTCTCCTGCCTCAGCCTCCCAAGTAGTGGGGATTACAGGCACACACAGGCA

37860 CACACAGCCACACCCAGATAATTTTTGTGTTTTCAGTAGGGACGGGGTTTCACCATGTTG

37920 GCCAGGCTGTCTCGAACTCCTGACCTCAGGTGATCTTCCCGCCTCAGCCTCCCAAAATGC

<-- AluSx

37980 TGGAATTACAGACATGAGCCACCGCACTGAGCCAGGTTTCTGATTTTCAACATCTGTTGA

38040 ATGCACAGCCTTCTCTGGTCTCTTATGTGATAGTTCGGGGACTGATTGGAAAGAGTTGGA

38100 ATCAGGGGATGGAGAATGGGGACAGATGGGACTAAGGACTCAGTGCACAAAGCTCCCCTT

38160 ATCACAGAAAGCAGCCCTTTCTCTCCGTGTGAGGAGGCTGTTCCTGCCTTGCTGGAAGAA

38220 CTATGGTTCTTGCCTGAGGAAGTCAAGTTGCCTTGTGTCTCCCACTTCTCATTTTCTTCA

M+38.3A/T

38280 AAGACAGAACTAGATACCAACATATCCCTCATTTTATAAAGCCAACCCTGGATGGAGAAT

Last updated: 8 September, 2005
Celia A. May
The views expressed in this document are those of the document owner, Alec J. Jeffreys.