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Research projects on Diversity, Genetics, Genomics, Molecular Cytogenetics, Chromosomes,
Genome Organization, Cells and Systems Biology in Crop Plants and other Species
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All biological systems involve complex networks with genes and regulatory interactions. In this manuscript with the lab of Kwang-Hyun Cho, KAIST, Korea, we develop an algorithm that systematically removes redundant verticies and nodes from a complete network, leaving a simplified "kernel" that is functionally and dynamically equivalent to the original complex network. The full paper is at 10.1126/scisignal.2001390. The paper was chosen for an Editor's Summary here and the concept is illustrated on the cover of the issue. J.-R. Kim, J. Kim, Y.-K. Kwon, H.-Y. Lee, P. Heslop-Harrison, K.-H. Cho, Reduction of Complex Signaling Networks to a Representative Kernel. Sci. Signal. 4, ra35 (2011). |
A discussion and more pictures related to the interview of Pat Heslop-Harrison by Jay Rayner is posted on www.AoBBlog.com. This site also encourages comments and questions about the article. Pictures of banana diseases and the banana genome are shown in a recent lecture here - sorry for the large PDF download. This website, www.molcyt.com, gives technical information about our research projects, including links to the primary publications which are used by other scientists, plant breeders and policy makers, as well as by students studying these areas.
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The molecular cytogenetics research group at the University of Leicester studies the diversity, evolution and function of the chromosomes, genes and other nuclear DNA of plant and animals. Our work has a focus on crop plants and their wild relatives as well as model plants, fungi, bacteria and animals (Drosophila and cows). We make and use new hybrid plants to investigate the transfer and exploitation of novel genetic diversity in crops. The techniques include molecular biology and genomics, bioinformatics, systems biology, growing and crossing plants, and techniques include microscopy and in situ hybridization to examine the physical organization of DNA sequences that make up the genome. Collaboration with groups internationally is very important, and we work on joint research projects with many countries, both for gaining applicable results and training or technology transfer: in the first half of the year 2011, we have had people from 15 countries from four continents working with us here in Leicester.
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The second shows control of pigment production by phytochrome involving reception of red and far red light
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The Annals of Botany Blog features Snapshots of all the papers published in this primary academic Journal, and news items about everything botanical - from the Plant Cuttings, and from other Journals and the press around the world. As Editor, Pat Heslop-Harrison writes his own blogs about, mostly but not entirely, botany, science and dissemination. Along with my colleagues involved with editing and the website development, we hope that the features relevant to plant science, the environment and our own interests, will reach a new audience and show some of the exciting work we are doing!
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Pat Heslop-Harrison, Trude Schwarzacher and the Molecular Cytogenetics and Plant Cell Biology Group study the biology of the cell nucleus: its spatial and dynamic organisation or architecture, the function and interactions of its components, and the nature, evolution, expression, recombination and segregation of the DNA sequences within the nucleus at interphase, mitosis and meiosis. We look at repetitive DNA and its evolution, with a particular focus on tandemly repeated satellite sequences and retrotransposons. We look at the biodiversity of genes, particularly in crops, and those related to pathology and disease resistance, sustainability and consumer traits, and abiotic stress and have interests in sources and uses of genomic mutations. Key methods include molecular cytogenetics, DNA sequence analysis and systems biology approaches. Taking a comparative genomics approach, we have interlinked projects with a range of different species: a particular focus is on plant crop species (banana, cereals including wheat, rye and barley, Brassicas, Saffron Crocus and Pea/Groundnut), while important projects include work with Dictyostelium and E. coli, Drosophila, Scallops (Pecten), and bovids. We have a number of projects on germplasm utilization in plant breeding.
Related websites: www.SBLab.org for our Systems Biology work. Link to PubMed database and paper downloads (click on 'page' icon next to title).
Our work is
important in showing the evolution and interaction of the majority of sequences in the
genome, and their physical and functional relationships. The unifying
aim of our work in terms of fundamental biology is the understanding of
the dynamic and functional architecture of the cell nucleus, leading to
an integrated structural, physical and functional map of the genome.
The current projects are within the University of Leicester. As part of cell biology, our interests include the RNA and proteins located within the nucleus, and their temporal and spatial relationships. We take a comparative approach to genome analysis, investigating many different species to find universal and species-specific features of genome organization. In animals, we work with the Bovideae, rodents and some insects. Within plants, we work with the Gramineae (wheat, rye, barley), Chenopodiaceae (sugar beet), Palmae (oil palm), Pinaceae (pine, spruce), Leguminoseae, Iridacae (Crocus), Cruciferae (Brassica and Arabidopsis), Musaceae (banana). In systems biology, we use Dictyostelium models. Pat Heslop-Harrison is Professor of Molecular Cytogenetics and Cell Biology at the University of Leicester. His interests include genetic diversity, crop evolution and breeding. Pat Heslop-Harrison moved from the Karyobiology Group, John Innes Centre, Norwich UK in October 2000. Trude Schwarzacher is Lecturer in Molecular cytogenetics in the University of Leicester. She moved from the Cereals Department, John Innes Centre in January 2001. To assist indexing programmes, this home page is designed to be key-word rich, and variant spellings are used (e.g. organization/organisation, labelling/labeling, hybridization/hybidisation). Sadly my Dawes Kara kum Karakum bike bicycle second hand used red forks silver gray frame 20" 22" was stolen serial number Dawes Karakum J20400801 J 20400801 was stolen from the University - any info to phh4(a)le.ac.uk r )
www.molcyt.com - index.htm |
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An algorithm to reduce complexity but maintain dynamic properties of networks
Yes, we have no bananas ... 
Annals of Botany Blog: 
Large scale organization and evolution of genomes
